中文名 | 1-(1-乙基丙基)-6-乙炔基-1,3-二氢-2H-咪唑并[4,5-B]吡嗪-2-酮 |
英文名 | Tirasemtiv |
别名 | 化合物TIRASEMTIV 1-(1-乙基丙基)-6-乙炔基-1,3-二氢-2H-咪唑并[4,5-B]吡嗪-2-酮 |
英文别名 | CK 2017357 TiraseMtiv Tirasemtiv TIRASEMTIV(CK-2017357) Tirasemtiv(CK-2017357) tiraseMtiv (CK-2017357) 6-ethynyl-1-(pentan-3-yl)-1H-iMidazo[4,5-b]pyrazin-2-ol 6-ETHYNYL-1-(PENTAN-3-YL)-1H-IMIDAZO[4,5-B]PYRAZIN-2(3H)-ONE 1-(1-Ethylpropyl)-6-ethynyl-1,3-dihydro-2H-imidazo[4,5-b]pyrazin-2-one Tirasemtiv 1-(1-Ethylpropyl)-6-ethynyl-1,3-dihydro-2H-imidazo[4,5-b]pyrazin-2-one Tirasemtiv 1-(1-Ethylpropyl)-6-ethynyl-1,3-dihydro-2H-imidazo[4,5-b]pyrazin-2-one |
CAS | 1005491-05-3 |
化学式 | C12H14N4O |
分子量 | 230.27 |
熔点 | >130°C (dec.) |
溶解度 | DMSO (微溶) 、甲醇 (微溶) |
存储条件 | -20°C Freezer |
外观 | 固体 |
颜色 | Beige to Brown |
物化性质 | 生物活性 Tirasemtiv (CK-2017357, CK-357) 是一种直接的 fast skeletal muscle troponin 的激活剂,可使肌节对钙敏感。 |
参考资料 展开查看 | 1: Sanders DB, Rosenfeld J, Dimachkie MM, Meng L, Malik FI; Tirasemtiv in Myasthenia Gravis Study Group. A Double-Blinded, Randomized, Placebo-Controlled Trial to Evaluate Efficacy, Safety, and Tolerability of Single Doses of Tirasemtiv in Patients with Acetylcholine Receptor-Binding Antibody-Positive Myasthenia Gravis. Neurotherapeutics. 2015 Apr;12(2):455-60. doi: 10.1007/s13311-015-0345-y. PubMed PMID: 25742919; PubMed Central PMCID: PMC4404445. 2: Bauer TA, Wolff AA, Hirsch AT, Meng LL, Rogers K, Malik FI, Hiatt WR. Effect of tirasemtiv, a selective activator of the fast skeletal muscle troponin complex, in patients with peripheral artery disease. Vasc Med. 2014 May 28;19(4):297-306. [Epub ahead of print] PubMed PMID: 24872402. 3: Hwee DT, Kennedy A, Ryans J, Russell AJ, Jia Z, Hinken AC, Morgans DJ, Malik FI, Jasper JR. Fast skeletal muscle troponin activator tirasemtiv increases muscle function and performance in the B6SJL-SOD1G93A ALS mouse model. PLoS One. 2014 May 7;9(5):e96921. doi: 10.1371/journal.pone.0096921. eCollection 2014. PubMed PMID: 24805850; PubMed Central PMCID: PMC4013064. 4: Hansen R, Saikali KG, Chou W, Russell AJ, Chen MM, Vijayakumar V, Stoltz RR, Baudry S, Enoka RM, Morgans DJ, Wolff AA, Malik FI. Tirasemtiv amplifies skeletal muscle response to nerve activation in humans. Muscle Nerve. 2014 Dec;50(6):925-31. doi: 10.1002/mus.24239. PubMed PMID: 24634285; PubMed Central PMCID: PMC4260123. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 4.343 ml | 21.714 ml | 43.428 ml |
5 mM | 0.869 ml | 4.343 ml | 8.686 ml |
10 mM | 0.434 ml | 2.171 ml | 4.343 ml |
5 mM | 0.087 ml | 0.434 ml | 0.869 ml |
微信搜索化工百科或扫描下方二维码,添加化工百科小程序,随时随地查信息!