中文名 | 柚甙 |
英文名 | Naringin |
别名 | 柚苷 柚甙 柚皮甙 柚皮苷 柚皮甙水合物 柚皮苷水合物 纳米脂质体柚皮苷 柚皮苷(分析标准品) NARINGIN 柚皮苷 标准品 7-[[2-O-(6-脱氧-A-L-甘露吡喃基)-B-D-葡萄吡喃基]氧代]-2,3-二氢-5-羟基-2-(4-羟苯基)-4H-1-苯并吡喃-4-酮 |
英文别名 | Naringin Aurantiin Naringoside (s)-yranosyl]oxy]- NARINGIN WITH HPLC Citrus grandis Osbeck 4',5,7-trihydroxyflavanone 7-rhamnoglucoside 2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-,(S)- 4h-1-benzopyran-4-one,7-[[2-o-(6-deoxy-alpha-l-mannopyranosyl)-beta-d-glucop 7-(2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyloxy)-2,3-dihydro-4',5,7-trihydroxyflavone 7-[[2-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(4-4H-1-Benzopyran-4-one 7-[[2-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-5-hydroxy-2(S)-(4-hydroxyphenyl)-4H-1-benzopyran-4-one 5-Hydroxy-2-(4-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl-2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside 5-Hydroxy-2-(4-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside 7-[[2-O-(6-Deoxy-a-L-mannopyranosyl)-b-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one (2S)-5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside 2-O-(6-Désoxy-alpha-L-mannopyranosyl)-bêta-D-glucopyranoside de 5-hydroxy-2-(4-hydroxyphényl)-4-oxo-3,4-dihydro-2H-chromén-7-yle (2S)-5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-alpha-D-glucopyranoside (2S)-5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl 2-O-(6-deoxy-alpha-D-galactopyranosyl)-beta-D-glucopyranoside 4H-1-benzopyran-4-one, 7-[[2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)- 4H-1-Benzopyran-4-one,7-[[2-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-,(S)- 7-{[(2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-(hydroxymethyl)-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}tetrahydro-2H-pyran-2-yl]oxy}-5-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-on 7-{[(2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-(hydroxymethyl)-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}tetrahydro-2H-pyran-2-yl]oxy}-5-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one 7-{[(2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-(hydroxyméthyl)-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-méthyltétrahydro-2H-pyran-2-yl]oxy}tétrahydro-2H-pyran-2-yl]oxy}-5-hydroxy-2-(4-hydroxyphényl)-2,3-dihydro-4H-chromén-4-one |
CAS | 10236-47-2 |
EINECS | 233-566-4 |
化学式 | C27H32O14 |
分子量 | 580.53 |
InChI | InChI=1/C27H32O14/c1-10-20(32)22(34)24(36)26(37-10)41-25-23(35)21(33)18(9-28)40-27(25)38-13-6-14(30)19-15(31)8-16(39-17(19)7-13)11-2-4-12(29)5-3-11/h2-7,10,16,18,20-30,32-36H,8-9H2,1H3/t10-,16-,18+,20-,21+,22+,23-,24+,25+,26-,27-/m0/s1 |
密度 | 1.3285 (rough estimate) |
熔点 | 166 °C |
沸点 | 559.35°C (rough estimate) |
比旋光度 | -91 º (c=1, C2H5OH) |
闪点 | 308.5°C |
水溶性 | Soluble in water, alcohol, acetone and warm acetic acid. |
蒸汽压 | 2.25Pa at 20℃ |
溶解度 | 溶于甲醇、乙醇、丙酮、醋酸、稀碱溶液和热水,常温下,在水中的溶解度为0.1%,75°C时可达10%。不溶于石油醚、乙醚、苯和氯仿等非极性溶剂。 |
折射率 | -84 ° (C=2, EtOH) |
酸度系数 | 7.17±0.40(Predicted) |
存储条件 | 2-8°C |
敏感性 | Avoid light and high temperature |
外观 | 结晶 |
颜色 | off-white |
Merck | 14,6425 |
BRN | 102012 |
物化性质 | 系葡萄糖、鼠李糖和柚配质的复合体。白色至浅黄色结晶性粉末,在水中结晶者,为含6~8个结晶水的结晶体,熔点83℃。在110℃下干燥后可得含2个结晶水的物质,熔点171℃。极苦,用水稀释5万倍后仍有苦感。在常温水中的溶解度为0.1%,75℃时为10%。溶于丙酮、乙醇、温醋酸和氢氧化钠液。经水解加氢后所得“柚苷二氢查耳酮”为甜味剂,甜度约为蔗糖的150倍。 |
MDL号 | MFCD00148888 |
危险品标志 | Xn - 有害物品 Xi - 刺激性物品 |
风险术语 | R22 - 吞食有害。 R36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
安全术语 | S22 - 切勿吸入粉尘。 S24/25 - 避免与皮肤和眼睛接触。 S36 - 穿戴适当的防护服。 S26 - 不慎与眼睛接触后,请立即用大量清水冲洗并征求医生意见。 |
WGK Germany | 3 |
RTECS | QN6340000 |
FLUKA BRAND F CODES | 3 |
TSCA | Yes |
海关编号 | 29389090 |
下游产品 | ω-苄基苯乙酮 新橙皮甙二氢查尔酮 野漆树苷 |
参考资料 展开查看 | 1. 黄湘 陈丰连 曹骋 等. HPLC-ELSD全成分指纹图谱研究疏肝理脾方配伍前后化学成分的变化[J]. 化学与生物工程 2020 037(001):59-64. 2. 宋晓芳 范宝磊 曾祥玲 李婷婷 史玉敏 邹晶晶 杨洁 陈洪国.HPLC-MS/MS法同时测定不同桂花品种中7个多酚类活性成分的含量[J].药物分析杂志 2019 39(10):1811-1820. 3. 杨成梓 范兴 包侠萍 等. HPLC同时测定芪骨胶囊中5种成分的含量[J]. 中国实验方剂学杂志 2015 021(016):60-63. 4. 郭琳 黄平情 于颖超 等. HPLC法同时测定胃康宁颗粒中5种成分的含量[J]. 中华中医药杂志 2020 v.35(01):139-142. 5. 沈虹 邓可众 钟志奎 等. HPLC法同时测定酸橙花的多成分含量及不同花期的质量分析[J]. 中药材 2018 041(008):1914-1917. 6. 范兴 杨成梓 曾伟生 等. HPLC法测定烫骨碎补中柚皮苷的含量[J]. 海峡药学 2013 25(11):74-76. 7. 贾田芊 JIA Tianqian 田曼 等. LC-MS/MS测定大鼠血浆中烟花苷浓度及其药代动力学和生物利用度[J]. 中国现代中药 2019 21(12):1625-1629. 8. 谢辉 陈亚 雷爱玲 等. SPE-HPLC-DAD法同时检测柑橘药用资源中黄烷酮类和川陈皮素成分[J]. 天然产物研究与开发 2019(8). 9. 侯留鑫 王华清 郑铁松 等. 一种新型茶叶籽黄酮单体的分离鉴定及其抗氧化活性[J]. 食品科学 2013 34(21):115-120. 10. 邓可众 陈虹 熊艺 等. 不同产地及不同采收期江枳实的UPLC指纹图谱研究[J]. 中药材 2017 040(009):2051-2054. 11. 曾鸿莲 刘振丽 宋志前 王淳 董运茁 宁张弛 赵思宇 舒一崧 何丹 王梦蕾 甘嘉荷 刘元艳.不同品种枳实HPLC指纹图谱及成分含量差异性研究[J].中国中药杂志 2016 41(17):3272-3278. 12. 李景 林立. 响应面法优选骨碎补总黄酮的超声提取工艺[J]. 福建中医药 2017 048(004):40-42. 13. 石艺婷, 何英杰, 陈芸,等. 基于CRITIC法计算权重系数的枳壳综合品质研究[J]. 中国现代中药 2019年21卷5期, 598-602,615页, ISTIC CA, 2019. 14. 芦海生,李婷,姜丹,孙宇峰,常晓茜,胡小松,刘春生.基于DNA条形码、UPLC及色度学方法鉴定与评价化橘红[J].中国中药杂志,2019,44(20):4419-4425. 15. 褚晓文, 韩飞, 宋爱华,等. 基于HPLC-FT-ICR MS技术的栀子大黄汤在大鼠胆汁中原形成分及代谢产物的分析鉴定[J]. 沈阳药科大学学报, 2019, v.36;No.286(11):54-66+96. 16. 许守超, 陈屠梦, 包绍印,等. 基于响应面试验设计优选衢枳壳多指标成分工艺研究[J]. 中药材 2019年42卷11期, 2617-2621页, MEDLINE ISTIC PKU, 2020. 17. 张春燕, 张冰冰, 路建饶,等. 多指标综合加权评分法优选宁神颗粒提取工艺研究[J]. 上海中医药杂志, 2019. 18. 张春燕, 潘蓉蓉, 张冰冰,等. 宁神颗粒质量控制研究[J]. 辽宁中医杂志, 2020, v.47;No.514(03):160-164. 19. 高俊丽, 邵艳华, 李倩,等. 广陈皮及其近缘种药用植物的HPTLC研究[J]. 中国现代中药, 2015, 17(010):1020-1025. 20. 盛钊君,葛思媛,张焜,谭永权,刘泽璇,李裕琳,谢芳英,陈小乐.新会柑胎仔与青皮、陈皮的黄酮含量分析与比较[J].食品研究与开发,2017,38(20):135-139. 21. 黄娟, 张靖, 宫璐,等. 枳壳精准煮散饮片质量的均一性[J]. 世界中医药, 2017, 012(011):2791-2794. 22. 王海燕, 梁利香, 李娟,等. 柚皮苷脂质体凝胶的处方制备工艺及质量控制研究[J]. 中国药房, 2015, v.26;No.544(34):4856-4859. 23. 王海燕, 陈月华, 李娟,等. 柚皮苷脂质体缓释凝胶制备工艺优化[J]. 湖北农业科学, 2016, v.55;No.554(05):1252-1255. 24. 魏强华, 洪晓婷, 林玉香,等. 沙田柚皮中柚皮苷和果胶综合提取工艺研究[J]. 中国食品添加剂, 2013, 000(002):104-110. 25. 杨希娟, 党斌, 樊明涛. 溶剂提取对青稞中不同形态多酚组成及抗氧化活性的影响[J]. 食品科学, 2018, 39(24):246-255. 26. 董丽萍, 赵家莹, 詹梁,等. 经典名方温胆汤中枳实模拟古法的炮制工艺与质量控制研究[J]. 上海中医药杂志, 2019, v.53;No.597(10):96-102. 27. 郁萌, 刘春泉, 牛丽影,等. 脱苦处理对枸橼汁品质的影响[J]. 江苏农业科学, 2014, 42(002):211-214. 28. 洪晓婷, 魏强华, 林玉香,等. 超声波辅助提取沙田柚皮中柚皮苷工艺的研究[J]. 广东轻工职业技术学院学报, 2012, 11(3):32-37. 29. 吕朝耕, 杨健, 康传志,等. 铁皮石斛中10种黄酮类成分UPLC-MS/MS测定与多糖组成含量分析[J]. 中国实验方剂学杂志, 2017, 023(017):47-52. 30. 邬子彬, 胡基志, 羌宇,等. 黑曲霉所产α-L-鼠李糖苷酶制备普鲁宁[J]. 南昌大学学报(理科版), 2017, 41(06):55-60. 31. 程喆, 潘思轶. 柚皮苷纳米乳化体系的制备及其稳定性研究[J]. 华中农业大学学报, 2019(4). 32. 黑青稞麸皮结合态酚类物质大孔树脂分离纯化工艺优化 33. 王维,赵子龙,高伟,张东勇,张路阳,包义君.柚皮苷对胶质瘤细胞生长的抑制作用的机制研究[J].沈阳药科大学学报,2020,37(09):815-818. 34. 彭颖,何婉莺,范鑫,卢琪,何小燕,潘思轶.柚皮苷二氢查尔酮的抗氧化活性研究[J].中国食品学报,2021,21(02):45-54. 35. 刘嘉丽,刘德明,王丹,张鸿,董新荣,童建华.湖南柑橘果皮总黄酮及橙皮苷含量分析[J].湖南农业科学,2020(11):58-62. 36. 贾田芊,郭天元,田曼,翟思程,杨青,孙静.LC-MS/MS测定烟花苷在大鼠体内及排泄物中分布情况[J].中药药理与临床,2020,36(06):69-76. 37. 张雪,朱子豪,章博,郭兴杰.纤维素键合手性固定相法分离5种黄烷酮糖苷类药物异构体[J].沈阳药科大学学报,2020,37(10):903-907. 38. 薛梦洁,于卉娟,王璐瑶,柴欣,杨静,王跃飞.血府逐瘀汤提取过程中成分的量变规律研究[J].天津中医药,2021,38(01):109-112. 39. 李文峰,张向阳,王翠,林兰婷,陈小平,屈阳,张雪梅,林瑶,谭飔,郑俏然,高晓旭.茎瘤芥的气体射流冲击干燥动力学及多酚降解动力学特征[J].食品科学,2021,42(05):106-114. 40. 赵萌萌,张文刚,党斌,杨希娟,张杰,甘生智.超微粉碎对青稞麸皮粉多酚组成及抗氧化活性的影响[J].农业工程学报,2020,36(15):291-298. 41. 徐艳阳,赵玉娟,高峰,王二雷,鲁海玲,李雪凤,姜雯雯,陈艳.高效液相色谱法分析中国人参不同部位中多酚类化合物[J].食品科学,2021,42(04):240-246. 42. Ping Liu, Yifei Bian, Yingsai Fan, Jia Zhong, and Zhongjie Liu,Protective Effect of Naringin on In Vitro Gut-Vascular Barrier Disruption of Intestinal Microvascular Endothelial Cells Induced by TNF-α, Journal of Agricultural and Food Chemistry 2020 68 (1), 43. Zhang X, Han L, Liu J, et al. Pharmacokinetic Study of 7 Compounds Following Oral Administration of Fructus Aurantii to Depressive Rats. Frontiers in Pharmacology. 2018 ;9:131. DOI: 10.3389/fphar.2018.00131. PMID: 29556193; PMCID: PMC5845165. 44. Guo, Xiao, et al. "Intestinal absorption and distribution of naringin, hesperidin, and their metabolites in mice." Journal of Functional Foods 74 (2020): 104158.https://doi.org/10.1016/j.jff.2020.104158 45. [IF=5.81] Zhang Xianhua et al."Pharmacokinetic Study of 7 Compounds Following Oral Administration of Fructus Aurantii to Depressive Rats."Front Pharmacol. 2018 Mar;0:131 46. [IF=5.279] Yingying Wei et al."Hot Air Treatment Induces Disease Resistance through Activating the Phenylpropanoid Metabolism in Cherry Tomato Fruit."J Agr Food Chem. 2017;65(36):8003–8010 47. [IF=4.952] Xiaoju Tian et al."The effects of alcohol fermentation on the extraction of antioxidant compounds and flavonoids of pomelo peel."Lwt Food Sci Technol. 2018 Mar;89:763 48. [IF=3.645] Weiquan Dai et al."Simultaneous chemical fingerprint and quantitative analysis of Rhizoma Smilacis Glabrae by accelerated solvent extraction and high-performance liquid chromatography with tandem mass spectrometry."J Sep Sci. 2015 May;38(9):1466-1475 49. [IF=3.205] Dong-Dong Hu et al."Simultaneous determination of ten compounds in rat plasma by UPLC-MS/MS: Application in the pharmacokinetic study of Ma-Zi-Ren-Wan."J Chromatogr B. 2015 Sep;1000:136 50. [IF=7.514] Jing Zhao et al."A sensitive and practical ELISA for analyzing naringenin in pummelo and herb samples."Food Chem. 2021 Nov;362:130223 51. [IF=6.543] Wang Yue et al."Polymethoxyflavones in Citrus Regulate Lipopolysaccharide-Induced Oscillating Decay of Circadian Rhythm Genes by Inhibiting Nlrp3 Expression."Oxid Med Cell Longev. 2021;2021:8419415 52. [IF=5.455] Ning Zi-Wan et al."Simultaneous UPLC–TQ-MS/MS determination of six active components in rat plasma: application in the pharmacokinetic study of Cyclocarya paliurus leaves."Chin Med-Uk. 2019 Dec;14(1):1-11 53. [IF=5.34] Jing Zhang et al."Application of “spider-web” mode in discovery and identification of Q-markers from Xuefu Zhuyu capsule."Phytomedicine. 2020 Oct;77:153273 54. [IF=5.279] Jiajing Chen et al."Primary Bitter Taste of Citrus is Linked to a Functional Allele of the 1,2-Rhamnosyltransferase Gene Originating from Citrus grandis."J Agr Food Chem. 2021;69(34):9869–9882 55. [IF=5.279] Feng Wang et al."Naringin Alleviates Atherosclerosis in ApoE–/– Mice by Regulating Cholesterol Metabolism Involved in Gut Microbiota Remodeling."J Agr Food Chem. 2020;68(45):12651–12660 56. [IF=5.279] Feng Wang et al."Four Citrus Flavanones Exert Atherosclerosis Alleviation Effects in ApoE–/– Mice via Different Metabolic and Signaling Pathways."J Agr Food Chem. 2021;69(17):5226–5237 57. [IF=4.952] Guanyi Peng et al."Combined microwave and enzymatic treatment improve the release of insoluble bound phenolic compounds from the grapefruit peel insoluble dietary fiber."Lwt Food Sci Technol. 2021 Sep;149:111905 58. [IF=4.759] Miaoduo Deng et al."Preparation of a hydroxypropyl-β-cyclodextrin functionalized monolithic column by one-pot sequential reaction and its application for capillary electrochromatographic enantiomer separation."J Chromatogr A. 2019 Oct;1603:269 59. [IF=4.451] Xiao Guo et al."Intestinal absorption and distribution of naringin, hesperidin, and their metabolites in mice."J Funct Foods. 2020 Nov;74:104158 60. [IF=4.411] Liuyi Yu et al."Systematic Detection and Identification of Bioactive Ingredients from Citrus aurantium L. var. amara Using HPLC-Q-TOF-MS Combined with a Screening Method."Molecules. 2020 Jan;25(2):357 61. [IF=4.36] Fansheng Kong et al."Optimization of extraction flavonoids from Exocarpium Citri Grandis and evaluation its hypoglycemic and hypolipidemic activities."J Ethnopharmacol. 2020 Nov;262:113178 62. [IF=4.192] Ping Liu et al."Protective Effect of Naringin on In Vitro Gut-Vascular Barrier Disruption of Intestinal Microvascular Endothelial Cells Induced by TNF-α."J Agr Food Chem. 2020;68(1):168–175 63. [IF=3.935] Jingyun Zheng et al."A systematic investigation on free phenolic acids and flavonoids profiles of commonly consumed edible flowers in China."J Pharmaceut Biomed. 2019 Aug;172:268 64. [IF=3.935] Zhengchao Ji et al."Global identification and quantitative analysis of representative components of Xin-Nao-Kang Capsule, a traditional Chinese medicinal formula, by UHPLC-Q-TOF-MS and UHPLC-TQ-MS."J Pharmaceut Biomed. 2021 May;198:114002 65. [IF=3.205] Jie Tang et al."Metabolite profiling of Shuganzhi tablets in rats and pharmacokinetics study of four bioactive compounds with liquid chromatography combined with electrospray ionization tandem mass spectrometry."J Chromatogr B. 2021 Aug;1179:122827 66. [IF=2.926] Li Bin-Chun et al."Target Discovery of Novel α-l-Rhamnosidases from Human Fecal Metagenome and Application for Biotransformation of Natural Flavonoid Glycosides."Appl Biochem Biotech. 2019 Dec;189(4):1245-1261 67. [IF=2.629] Lei Shan-Shan et al."Dendrobium officinale Regulates Fatty Acid Metabolism to Ameliorate Liver Lipid Accumulation in NAFLD Mice."Evid-Based Compl Alt. 2021;2021:6689727 68. [IF=2.629] Hu Jing et al."Chemometric Analyses for the Characterization of Raw and Stir-Frying Processed Drynariae Rhizoma Based on HPLC Fingerprints."Evid-Based Compl Alt. 2021;2021:6651657 69. [IF=2.408] Wei Ling et al."Evaluation of Pomelo Seed Extracts as Natural Antioxidant, Antibacterial, Herbicidal Agents, and Their Functional Components."Chemistry & Biodiversity. 2021 Oct 27 70. [IF=2.391] Tan Si et al."Effects of three drying methods on polyphenol composition and antioxidant activities of Litchi chinensis Sonn.."Food Sci Biotechnol. 2020 Mar;29(3):351-358 71. [IF=2.19] Sheng-xiang Yang et al."Extraction of flavonoids from Cyclocarya paliurus (Juglandaceae) leaves using ethanol/salt aqueous two-phase system coupled with ultrasonic."J Food Process Pres. 2020 Jun;44(6):e14469 72. [IF=1.312] Tie-xin Tang et al."A pattern recognition method on smartphones for planar chromatography and verification on chromatograms of four herbal medicines from citrus fruits."Journal Of Liquid Chromatography & Related Technologies. 2021 Aug 26 73. [IF=2.629] Mu Qixuan et al."Study on Closely Related Citrus CMMs based on Chemometrics and Prediction of Components-Targets-Diseases Network by Ingenuity Pathway Analysis."Evid-Based Compl Alt. 2022;2022:1106353 74. [IF=3.352] Tingting Bao et al."Naringin prevents follicular atresia by inhibiting oxidative stress in the aging chicken."Poultry Sci. 2022 Mar;:101891 75. [IF=3.638] Wenfeng Li et al."Zein enhanced the digestive stability of five citrus flavonoids via different binding interaction."Journal Of The Science Of Food And Agriculture. 2022 Mar 09 76. [IF=4.24] Bo Zou et al."Structural identification and antioxidant potency evaluation of pomelo vinegar polyphenols."Food Biosci. 2022 Jun;47:101674 77. [IF=5.165] Juanning Ren et al."Qualitative and quantitative analysis of multi-components in Xing-Su-Ning Capsules for quality improvement."Arab J Chem. 2022 Jun;15:103825 78. [IF=4.36] Guoxiu Liu et al."Sequential grade evaluation method exploration of Exocarpium Citri Grandis (Huajuhong) decoction pieces based on “network prediction → grading quantization → efficacy validation"."J Ethnopharmacol. 2022 Jun;291:115149 79. [IF=6.576] Mei Yang et al."Chemical Variation of Chenpi (Citrus Peels) and Corresponding Correlated Bioactive Compounds by LC-MS Metabolomics and Multibioassay Analysis."Front Nutr. 2022; 9: 825381 80. [IF=1.984] Xinye Liu et al."Comparative studies on physicochemical properties of gluten- And glutenin-based films functionalized by polyphenols."Cereal Chemistry. 2022 Jan 18 81. [IF=3.833] Xiao Guo et al."Involvement of phase II enzymes and efflux transporters in the metabolism and absorption of naringin, hesperidin and their aglycones in rats."International Journal Of Food Sciences And Nutrition. 2022 Jan 02 82. [IF=3.935] Junmao Li et al."Comprehensive chemical profiling of the flowers of Citrus aurantium L. var. amara Engl. and uncovering the active ingredients of lipid lowering."J Pharmaceut Biomed. 2022 Mar;211:114621 83. [IF=4.412] Hui-Min Jin et al."Polyphenol and Anthocyanin Composition and Activity of Highland Barley with Different Colors."MOLECULES. 2022 Jan;27(11):3411 84. [IF=6.53] Pan Sun et al."Jiangu granule ameliorated OVX rats bone loss by modulating gut microbiota-SCFAs-Treg/Th17 axis."BIOMEDICINE & PHARMACOTHERAPY. 2022 Jun;150:112975 85. [IF=4.616] Ruiyang Sun et al."Submicron 3,4-dihydroxybenzoic acid–TiO2 composite particles for enhanced MALDI MS imaging of secondary metabolites in the root of differently aged baical skullcap."ANALYST. 2022 May;: |
微信搜索化工百科或扫描下方二维码,添加化工百科小程序,随时随地查信息!