102394-31-0_化工百科

中文名	Otenzepad
英文名	6H-Pyrido(2,3-b)(1,4)benzodiazepin-6-one, 11-((2-((diethylamino)methyl)-1-piperidinyl)acetyl)-5,11-dihydro-
英文别名	Otenzepad 6H-Pyrido(2,3-b)(1,4)benzodiazepin-6-one, 11-((2-((diethylamino)methyl)-1-piperidinyl)acetyl)-5,11-dihydro-
CAS	102394-31-0
化学式	C24H31N5O2
分子量	421.54
溶解度	DMSO : 10 mg/mL母液保存：分装冻存，避免反复冻融；-20℃，1个月；-80℃，6个月（稀释后溶液温度低保存可能会析出，尽量现用现配）
存储条件	-20℃
产品用途	Otenzepad, also known as AF-DX 116, is a selective M2 antagonist. Oral AF-DX 116 resulted in greater elevation of DBP than SBP in unstressed rats. In stressed rats, greater and more prolonged elevation of SBP than in unstressed rats was noted, particularly at higher doses. he effects of AF-DX 116 on blood pressure and heart rate thus may arise from peripheral action and AF-DX 116 may be useful for treating hypotension related to autonomic imbalance of the vagotonia type.
靶点	M2 muscarinic acetylcholine receptor in rabbit peripheral lung M2 muscarinic acetylcholine receptor in rat heart
参考资料展开查看	1: Sahin L, Cevik OS, Koyuncu DD, Buyukafsar K. Role of rho-kinase (ROCK) in tonic but not phasic contraction in the frog stomach smooth muscle. Life Sci. 2018 Apr 1;198:46-55. doi: 10.1016/j.lfs.2018.02.023. Epub 2018 Feb 15. PubMed PMID: 29455004. 2: Leaderbrand K, Chen HJ, Corcoran KA, Guedea AL, Jovasevic V, Wess J, Radulovic J. Muscarinic acetylcholine receptors act in synergy to facilitate learning and memory. Learn Mem. 2016 Oct 17;23(11):631-638. doi: 10.1101/lm.043133.116. Print 2016 Nov. PubMed PMID: 27918283; PubMed Central PMCID: PMC5066603. 3: Zhu Y, Chen SR, Pan HL. Muscarinic receptor subtypes differentially control synaptic input and excitability of cerebellum-projecting medial vestibular nucleus neurons. J Neurochem. 2016 Apr;137(2):226-39. doi: 10.1111/jnc.13554. Epub 2016 Feb 15. PubMed PMID: 26823384; PubMed Central PMCID: PMC4828279. 4: Anderson RW, Strowbridge BW. Regulation of persistent activity in hippocampal mossy cells by inhibitory synaptic potentials. Learn Mem. 2014 Apr 15;21(5):263-71. doi: 10.1101/lm.033829.113. PubMed PMID: 24737918; PubMed Central PMCID: PMC3994498. 5: Barathi VA, Kwan JL, Tan QS, Weon SR, Seet LF, Goh LK, Vithana EN, Beuerman RW. Muscarinic cholinergic receptor (M2) plays a crucial role in the development of myopia in mice. Dis Model Mech. 2013 Sep;6(5):1146-58. doi: 10.1242/dmm.010967. Epub 2013 May 2. PubMed PMID: 23649821; PubMed Central PMCID: PMC3759334. 6: Arrighi N, Bodei S, Zani D, Michel MC, Simeone C, Cosciani Cunico S, Spa

102394-31-0 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	2.372 ml	11.861 ml	23.723 ml
5 mM	0.474 ml	2.372 ml	4.745 ml
10 mM	0.237 ml	1.186 ml	2.372 ml
5 mM	0.047 ml	0.237 ml	0.474 ml

最后更新：2024-01-02 23:10:35

上海吉至生化科技有限公司

现货供应

产品名: 11-((2-((二乙氨基)甲基)-1-哌啶基)乙酰基)-5,11-二氢-(6H)-吡啶并[2.3-b][1.4]苯并二氮杂-6-酮去供应商网站查看询盘
CAS: 102394-31-0
产地: 中国上海
包装: 1mg
规格: 98%
价格: 1348.00
库存: 现货
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013

微信: 18017137653
产品描述: 中文名：11-((2-((二乙氨基)甲基)-1-哌啶基)乙酰基)-5,11-二氢-(6H)-吡啶并[2.3-b][1.4]苯并二氮杂-6-酮英文名:Otenz 更多

上海麦克林生化科技股份有限公司

现货供应

产品名: 11-((2-((二乙氨基)甲基)-1-哌啶基)乙酰基)-5,11-二氢-(6H)-吡啶并[2.3-B][1.4]苯并二氮杂-6-酮去供应商网站查看询盘
CAS: 102394-31-0
产地: 上海
规格: D921292
价格: 1mg-421
库存: 7天内发货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2885703204/288570320

微信: 19863730987/17821173903

上海源叶生物科技有限公司

产品名: Otenzepad 去供应商网站查看询盘
CAS: 102394-31-0
产地: 上海
规格: 98%
价格: 5mg 1200,10mg 1800,25mg 3200,100mg 9140
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403