1048973-47-2
MDA 19(MDA 19)
CAS: 1048973-47-2
化学式: C21H23N3O2
| 中文名 | MDA 19 |
| 英文名 | MDA 19 |
| 别名 | N'-(1-己基-2-氧代吲哚啉-3-基亚甲基)苯甲酰肼 苯甲酸 (2Z)-2-(1-己基-1,2-二氢-2-氧代-3H-吲哚-3-亚基)肼 |
| 英文别名 | MDA19 MDA 19 MDA-19 N'-(1-Hexyl-2-oxoindolin-3-ylidene)benzohydrazide (Z)-N'-(1-hexyl-2-oxoindolin-3-ylidene)benzohydrazide N-[(Z)-(1-Hexyl-2-oxo-indolin-3-ylidene)aMino]benzaMide N'-[(3Z)-1-Hexyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]benzohydrazide Benzoic acid (2Z)-2-(1-hexyl-1,2-dihydro-2-oxo-3H-indol-3-ylidene)hydrazide MDA 19 (Z)-N'-(1-hexyl-2-oxoindolin-3-ylidene)benzohydrazide |
| CAS | 1048973-47-2 |
| EINECS | 200-258-5 |
| 化学式 | C21H23N3O2 |
| 分子量 | 349.43 |
| 密度 | 1.16±0.1 g/cm3 (20 ºC 760 Torr) |
| 酸度系数 | 10.45±0.20(Predicted) |
| 存储条件 | 2-8℃ |
| 体外研究 | MDA19 displayed 4-fold-higher affinity at the human CB(2) than at the human CB1 receptor (K(i) = 43.3 +/- 10.3 vs 162.4 +/- 7.6 nM) and nearly 70-fold-higher affinity at the rat CB2 than at the rat CB1 receptor (K(i) = 16.3 +/- 2.1 vs 1130 +/- 574 nM). In guanosine triphosphate (GTP)gamma[(35)S] functional assays, MDA19 behaved as an agonist at the human CB1 and CB2 receptors and at the rat CB1 receptor but as an inverse agonist at the rat CB2 receptor. In 3',5'-cyclic adenosine monophosphate (cAMP) assays, MDA19 behaved as an agonist at the rat CB1 receptor and exhibited no functional activity at the rat CB(2) receptor. In extracellular signal-regulated kinases 1 and 2 activation assays. |
| 体内研究 | MDA19 behaved as an agonist at the rat CB2 receptor. MDA19 attenuated tactile allodynia produced by spinal nerve ligation or paclitaxel in a dose-related manner in rats and CB2(+/+) mice but not in CB2(-/-) mice, indicating that CB2 receptors mediated the effects of MDA19. MDA19 did not affect rat locomotor activity. |
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