中文名 | NPPB |
英文名 | NPPB |
别名 | 5-硝基-2-(3-苯丙胺)苯甲酸 5-硝基-2-((3-苯基丙基)氨基)苯甲酸 |
英文别名 | NPPB C13705 Compound 144 5-NITRO-2-(3-PHENYLPROPYLAMINO)BENZOIC ACID 5-NITRO-2-(3'-PHENYLPROPYL-AMINO)BENZOIC ACID 3-Nitro-6-[(3-phenylpropyl)amino]benzoic acid 5-NITRO-2-(3-PHENYLPROPYLAMINO)BENZOIC A CID POTENT CHLORIDE CHANN |
CAS | 107254-86-4 |
化学式 | C16H16N2O4 |
分子量 | 300.31 |
密度 | 1.323±0.06 g/cm3(Predicted) |
熔点 | 178-180℃ |
沸点 | 523.5±50.0 °C(Predicted) |
溶解度 | 乙醇: 3mg/ml |
酸度系数 | 2.27±0.22(Predicted) |
存储条件 | -20°C |
外观 | 黄色固体 |
体外研究 | 0.1 mM NPPB in the bath solution reduces channel open probability from 0.89±0.06 to 0.11±0.04 (n=5, P<0.01). Dose-dependent inhibition of chloride currents is observed with a 50% inhibitory concentration (IC 50 ) of 125 μM NPPB. NPPB itself also shows cytotoxicity against glioma cells with a GI 50 of approximately 500 μM. |
WGK Germany | 3 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.33 ml | 16.65 ml | 33.299 ml |
5 mM | 0.666 ml | 3.33 ml | 6.66 ml |
10 mM | 0.333 ml | 1.665 ml | 3.33 ml |
5 mM | 0.067 ml | 0.333 ml | 0.666 ml |
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