中文名 | 盐酸特拉唑嗪 |
英文名 | (R)-Terazosin |
别名 | 盐酸特拉唑嗪 (R)-特拉唑嗪 盐酸特拉唑嗪杂质B 特拉唑嗪标准品2-R |
英文别名 | (R)-Terazosin Terazosin-002-R (R)-(4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(tetrahydrofuran-2-yl)methanone Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-, (R)- Methanone, [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl][(2R)-tetrahydro-2-furanyl]- Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[[(2R)-tetrahydro-2-furanyl]carbonyl]- (9CI) |
CAS | 109351-34-0 |
化学式 | C19H25N5O4 |
分子量 | 387.43 |
体外研究 | (R)-Terazosin is low affinity for α2a, α2B and α2c-adrenoceptor with K i values of 3.85 μM, 0.33 μM and 0.37 μM, respectively. (R)-Terazosin may prove to be a useful probe in understanding the functional role of subtypes of adrenoceptors in various tissues. Because it is a weaker antagonist at α2B sites than its enantiomer, it may be possible to use (R)-Terazosin to differentiate between pharmacological effects mediated by subtypes of α2-adrenoceptors in animal studies. |
体内研究 | (R)-Terazosin shows antagonism of at rat atrial α2B receptor with a pEC 30 of 5.69. (R)-Terazosin shows antagonism of at rat vas deferens α1A and α2A receptor with pA 2 values of 7.5 and 5.31, respectively. |
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