中文名 | 人参皂甙 Rc |
英文名 | ginsenoside rc |
别名 | 人参皂苷RC 人参皂甙RC 人参皂苷Rc 人叁皂甙RC 人参皂甙Rc 人参皂荚RC 人参皂甙 Rc 人参皂荚RB1 人参皂苷 RC, 来源于人参 人参皂苷RC(人参皂甙RC) GINSENOSIDE RC 人参皂苷RC |
英文别名 | ginsenoside rc Ginsenoside Rc glucopyranosyl- GINSENOSIDE RC WITH HPLC Ginsenoside Rc, Ginsenoside Rb2 hydroxydammar-24-en-3-yl2-O-β-D- arabinofuranosyl-β-D-glucopyranosyl)oxy]-12- GINSENOSIDE FROM GINSENG ROOT (PANAX*QUI NQUEFOLIUM ginsenoside-rc from panax quinquefolium (american ginseng)root 12-hydroxy-20-[(6-O-pentofuranosylhexopyranosyl)oxy]dammar-24-en-3-yl 2-O-hexopyranosylhexopyranoside 20-[(6-O-alpha-L-Arabinofuranosyl-beta-D-glucopyranosyl)oxy]-12b-hydroxydammar-24-en-3b-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside 20-[(6-O-alpha-L-arabinofuranosyl-beta-D-glucopyranosyl)oxy]-12beta-hydroxydammar-24-en-3beta-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside |
CAS | 11021-14-0 |
EINECS | 234-253-5 |
化学式 | C53H90O22 |
分子量 | 1079.27 |
InChI | InChI=1/C53H90O22/c1-23(2)10-9-14-53(8,75-47-43(67)39(63)37(61)29(72-47)22-68-45-41(65)36(60)28(21-56)69-45)24-11-16-52(7)33(24)25(57)18-31-50(5)15-13-32(49(3,4)30(50)12-17-51(31,52)6)73-48-44(40(64)35(59)27(20-55)71-48)74-46-42(66)38(62)34(58)26(19-54)70-46/h10,24-48,54-67H,9,11-22H2,1-8H3 |
密度 | 1.42±0.1 g/cm3(Predicted) |
熔点 | 199~201℃ |
沸点 | 1128.3±65.0 °C(Predicted) |
比旋光度 | (c, 1 in MeOH)+1.9 |
闪点 | 636.2°C |
蒸汽压 | 0mmHg at 25°C |
溶解度 | DMSO (微溶) 、甲醇 (微溶) 、吡啶 (微溶) |
折射率 | 1.621 |
酸度系数 | 12.85±0.70(Predicted) |
存储条件 | Sealed in dry,2-8°C |
稳定性 | 吸湿性 |
敏感性 | Easily absorbing moisture |
外观 | 固体 |
颜色 | White to Pale Yellow |
物化性质 | 白色结晶粉末,可溶于甲醇、乙醇、DMSO等有机溶剂,来源于人参根茎。 |
MDL号 | MFCD00133368 |
体外研究 | Ginsenoside Rc, one of major Ginsenosides from Panax ginseng, enhances γ-aminobutyric acid (GABA) receptor A (GABA A )-mediated ion channel currents. Ginsenoside Rc enhances GABA-mediated ion currents in oocytes expressing the GABA A receptor. Ginsenoside Rc significantly inhibits the expression of macrophage-derived cytokines, such as TNF-α and IL-1β. Ginsenoside Rc also markedly suppresses the activation of TANK-binding kinase 1/IκB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling in activated RAW264.7 macrophages, human synovial cells, and HEK293 cells. Ginsenoside Rc exerts its anti-inflammatory actions by suppressing TANK-binding kinase 1/IκB kinase ε/interferon regulatory factor-3 and p38/ATF-2 signaling. Ginsenoside Rc suppresses the nuclear translocation of phospho-ATF-2 and phospho-FRA-1, whereas the translocation of p65 at its peak time points (30 and 60 min) is not decreased by Ginsenoside Rc treatment. Ginsenoside Rc regulates the expression of the proinflammatory cytokine TNF-α, which is produced by macrophages, by suppressing AP-1 activation. |
危险品标志 | Xn - 有害物品 |
风险术语 | 20/21/22 - 吸入、皮肤接触及吞食有害。 |
安全术语 | S26 - 不慎与眼睛接触后,请立即用大量清水冲洗并征求医生意见。 S36 - 穿戴适当的防护服。 |
WGK Germany | 3 |
RTECS | LY9536300 |
海关编号 | 29389090 |
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