114568-26-2
帕莫司他(Patamostat)
CAS: 114568-26-2
化学式: C20H20N4O4S
| 中文名 | 帕莫司他 |
| 英文名 | Patamostat |
| 别名 | 帕莫司他 |
| 英文别名 | Patomostat Patamostat 4-(2-succinimidoethylthio)phenyl 4-guanidinobenzoate 4-Guanidinobenzoic acid 4-[[2-(2,5-dioxopyrrolidin-1-yl)ethyl]thio]phenyl ester Benzoic acid, 4-[(aminoiminomethyl)amino]-, 4-[[2-(2,5-dioxo-1-pyrrolidinyl)ethyl]thio]phenyl ester |
| CAS | 114568-26-2 |
| 化学式 | C20H20N4O4S |
| 分子量 | 412.46 |
| 存储条件 | 2-8°C，避光，干燥，密封 |
| 体内研究 | Intravenous infusion of Patamostat (E-3123) at 0.03-0.3 mg/kg in rats or at 0.3-3.0 mg/kg in rabbits reduced mortality after the induction of pancreatitis in a dose-dependent manner. In dogs with pancreatitis, increases in serum trypsin and lipase activities were significantly reduced by infusion of Patamostat at 1.0 and 3.0 mg/kg. Patamostat (E3123; continuous infusion in a dose of 2 mg/kg per h) improves almost all parameters, including mortality rate, serum and ascitic fluid amylase levels, plasma endotoxin and serum FDP levels, and distribution of lysosomal enzyme in male Wistar rats. Animal Model: Male Wistar rats weighing about 350 g Dosage: 2 mg/kg Administration: Continuous infusion per h for 1 h Result: Significantly improved the survival rate. |
