123606-23-5
N-1-(Fur-3-ylethyl)-N-hydroxyurea(A-69412)
CAS: 123606-23-5
化学式: C7H10N2O3
| 中文名 | N-1-(Fur-3-ylethyl)-N-hydroxyurea |
| 英文名 | A-69412 |
| 别名 | 化合物 T10208 |
| 英文别名 | A-69412 N-1-(fur-3-ylethyl)-N-hydroxyurea N-1-(Fur-3-ylethyl)-N-hydroxyurea N-[1-(3-Furanyl)ethyl]-N-hydroxyurea Urea, N-[1-(3-furanyl)ethyl]-N-hydroxy- |
| CAS | 123606-23-5 |
| 化学式 | C7H10N2O3 |
| 分子量 | 170.17 |
| 存储条件 | 2-8°C，密封，干燥 |
| 体外研究 | A-69412 inhibits the formation of 5-HETE by the 20000×g supernatant of RBL-I cells in a dose-dependent fashion. The shift to greater potency at lower substrate concentrations is consistent with A-69412 being a competitive inhibitor of the enzyme. A-69412 also inhibits the formation of LTB 4 in calcium ionophore A23187 stimulated human PMNL (IC 50 =8.9 μM). A-69412 is more potent in inhibiting LTB 4 formation in ionophore-stimulated human whole blood. The potency of A-69412 in a number of assays using several donors consistently show activity in the low micromolar range (mean IC 50 =1.4 μM, range 0.5-3 μM, 9 donors), several fold more potent than its activity in the other in vitro assays. |
| 体内研究 | Oral doses of A-69412 are found to inhibit leukotriene production in a number of species. For example, A-69412 is found to be a potent long-acting inhibitor of leukotriene formation in vivo in the rat (oral ED 50 =5 mg/kg). A-69412 is remarkably potent in the dog, giving nearly complete inhibition through 16 h after a single 5 mg/kg dose. Plasma concentrations in the dog studies are 38 μM at 0.5 h after dosing and 5 μM at 16 h. These data are consistent with the 100% inhibition seen ex vivo at 0.5 h post-dosing and the 90% inhibition seen at 16 h. As would be expected from the pharmacokinetic results, A-69412 is clearly superior to zileuton in the cynomolgus monkey. A-69412 gave >50% inhibition of ex vivo LTB 4 biosynthesis in the monkey for 8 h, while zileuton is effective only in the first 2 h after oral dosing. An anaphylactic reaction in the rat peritoneal cavity of passively sensitized animals produces large amounts of sulfidopeptide leukotrienes. Given as an oral solution, A-69412 dose-dependently inhibits leukotriene production in the peritoneal cavity of the rat. In one of the experiments, blood levels of A-69412 are measured. These values range from 4 to 100 μM with doses ranging from 2 to 50 mg/kg. A-69412 also significantly inhibits the reaction if dosed (10 mg/kg) at times up to 8 h before challenge. Plasma concentrations of A-69412 are measured in the time course studies and are found to range from 44 μM at 0.5 h to 10 μM at 8 h after dosing. |
123606-23-5 - 简介
N-1-(Fur-3-ylethyl)-N-hydroxyurea是一种有机化合物，其结构中含有三个主要部分：一个氢氧化脲基团，一个烷基基团（由双侧链和含有呋喃环的基团组成），以及一个羟基。以下是关于N-1-(Fur-3-ylethyl)-N-hydroxyurea的性质，用途，制法和安全信息的介绍：
性质：N-1-(Fur-3-ylethyl)-N-hydroxyurea是一种白色或微黄色的晶体。它可以在醇中溶解，但在水中溶解性较差。
制法：N-1-(Fur-3-ylethyl)-N-hydroxyurea的制备可以通过多个步骤来完成。通常是从商业可获得的原料开始，然后通过化学反应进行合成。具体的合成方法可能会因研究目的和实验条件而异。
它是一种化学制剂，可能对人体产生一定的毒性，在操作时需要佩戴合适的个人防护装备，如实验手套和护目镜。在储存时，应将其保存在干燥、阴凉和避光的环境中。最重要的是，使用过程中请遵守实验室的安全操作规范，并按照相关法规进行处理和处置废弃物。
性质：N-1-(Fur-3-ylethyl)-N-hydroxyurea是一种白色或微黄色的晶体。它可以在醇中溶解，但在水中溶解性较差。
制法：N-1-(Fur-3-ylethyl)-N-hydroxyurea的制备可以通过多个步骤来完成。通常是从商业可获得的原料开始，然后通过化学反应进行合成。具体的合成方法可能会因研究目的和实验条件而异。
它是一种化学制剂，可能对人体产生一定的毒性，在操作时需要佩戴合适的个人防护装备，如实验手套和护目镜。在储存时，应将其保存在干燥、阴凉和避光的环境中。最重要的是，使用过程中请遵守实验室的安全操作规范，并按照相关法规进行处理和处置废弃物。
最后更新：2024-04-09 20:44:15
供应商列表
现货供应
产品名: N-1-(Fur-3-ylethyl)-N-hydroxyurea 去供应商网站查看 询盘CAS: 123606-23-5
产地: 上海
规格: A938196
价格: 100mg-24000,50mg-14400,25mg-9600,10mg-4800
库存: 现货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2885703204/288570320
微信: 19863730987/17821173903
现货供应
产品名: N-1-(Fur-3-ylethyl)-N-hydroxyurea 去供应商网站查看 询盘CAS: 123606-23-5
产地: 上海
规格: A938196
价格: 100mg-24000,50mg-14400,25mg-9600,10mg-4800
库存: 现货
电话: 13816333479/17821173903
手机: 13816333479/17821173903
电子邮件: wangrui@macklin.cn
QQ: 2885703204/288570320
微信: 19863730987/17821173903
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