130477-52-0_化工百科

中文名	9H-咪唑并[1,5-a]吡咯并[2,1-C][1,4]苯二氮-1-羧酸11,12,13,13a-四氢-7-氧基-9-氧代乙基酯(13as)-
英文名	L-655,708
别名	化合物L-655708 9H-咪唑并[1,5-a]吡咯并[2,1-C][1,4]苯二氮-1-羧酸11,12,13,13a-四氢-7-氧基-9-氧代乙基酯(13as)- (S)-7-甲氧基-9-氧代-11,12,13,13A-四氢-9H-9H-咪唑并[1,5-A]吡咯并[2,1-C][1,4]苯二氮-1-羧酸乙酯
英文别名	MSD L-655,708 Ethyl (S)-11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate ETHYL (S)-11,12,13,13A-TETRAHYDRO-7-METHOXY-9-OXO-9H-IMIDAZO[1,5-A]PYRROLO[2,1-C][1,4]BENZODIAZEPINE-1-CARBOXYLATE Ethyl (S)-11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate 11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1.5-a]pyrrolo[2.1-c][1.4]benzodiazepine-1-carboxylicacidethylester ethyl (13aS)-7-methoxy-9-oxo-11,12,13,13a-tetrahydro-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate 11,12,13,13A-Tetrahydro-7-Methoxy-9-Oxo-9H-Imidazo[1,5-A]Pyrrolo[2,1-C][1,4]Benzodiazepine-1-Carboxylic Acid, Ethyl Ester 11,12,13,13A-TETRAHYDRO-7-METHOXY-9-OXO-9H-IMIDAZO[1,5-A]PYRROLO[2,1-C][1,4]BENZODIAZEPINE-1-CARBOXYLIC ACID, ETHYL ESTER 9H-Imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, 11,12,13,13a-tetrahydro-7-methoxy-9-oxo-, ethyl ester, (13aS)- 9H-IMidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, 11,12,13,13a-tetrahydro-7-Methoxy-9-oxo-, ethyl ester, (13aS)-
CAS	130477-52-0
化学式	C18H19N3O4
分子量	341.36
InChI	InChI=1/C18H19N3O4/c1-3-25-18(23)15-16-14-5-4-8-20(14)17(22)12-9-11(24-2)6-7-13(12)21(16)10-19-15/h6-7,9-10,14H,3-5,8H2,1-2H3/t14-/m0/s1
密度	1.42±0.1 g/cm3(Predicted)
熔点	175-176 °C
沸点	584.4±50.0 °C(Predicted)
闪点	307.2°C
蒸汽压	1.21E-13mmHg at 25°C
溶解度	DMSO: 6 mg/mL
折射率	1.675
酸度系数	1.49±0.20(Predicted)
存储条件	Desiccate at +4°C
外观	粉末
物化性质	溶解度：DMSO: 6 mg/mL WGK Germany：3
体外研究	L655708 is a potent, selective inverse agonist for the benzodiazepine site of GABAA receptors containing the α5 subunit (Ki = 0.45 nM). Displays 50-100-fold selectivity over GABAA receptors containing α1, α2, α3 orα6 subunits in combination with β3 and γ2. Enhances LTP in a mouse hippocampal slice model and increases spatial learning, without displaying proconvulsant activity.
体内研究	L-655708 at 0.7 mg/kg, administered intraperitoneally, would result in 60-70% occupancy of α5 GABAA receptors with limited binding to α1, α2, and α3 subunit-containing GABAA receptors and no significant off-target behavioral effects, such as sedation and motor impairment.
WGK Germany	3

130477-52-0 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	2.929 ml	14.647 ml	29.295 ml
5 mM	0.586 ml	2.929 ml	5.859 ml
10 mM	0.293 ml	1.465 ml	2.929 ml
5 mM	0.059 ml	0.293 ml	0.586 ml

最后更新：2024-01-02 23:10:35

上海吉至生化科技有限公司

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产品名: L-655,708 去供应商网站查看询盘
CAS: 130477-52-0
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产品描述: 中文名：L-655,708 英文名:L-655708 CAS:130477-52-0 规格:99% 产地:中国上海

上海麦克林生化科技股份有限公司

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产品名: L-655708 去供应商网站查看询盘
CAS: 130477-52-0
产地: 上海
规格: L883355
价格: 5mg-566,10mg-1029
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上海源叶生物科技有限公司

产品名: L-655,708 去供应商网站查看询盘
CAS: 130477-52-0
产地: 上海
规格: 98%
价格: 5mg 880,10mg 1550
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