中文名 | PU-WS13 |
英文名 | PU-WS13 |
别名 | HSP90抑制剂(PU-WS13) 6-氨基-8-[(3,5-二氯苯基)硫基]-N-异丙基-9H-嘌呤-9-丙胺 |
英文别名 | PUWS13 PU-WS13 CS-2047 CS-1689 PU WS13 8-((3,5-dichlorophenyl)thio)-9-(3-(isopropylamino)propyl)-9H-purin-6-amine 8-(3,5-dichlorophenyl)sulfanyl-9-[3-(propan-2-ylamino)propyl]purin-6-amine 6-Amino-8-[(3,5-dichlorophenyl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine 9H-Purine-9-propanamine, 6-amino-8-[(3,5-dichlorophenyl)thio]-N-(1-methylethyl)- |
CAS | 1454619-14-7 |
化学式 | C17H20Cl2N6S |
分子量 | 411.35 |
密度 | 1.47±0.1 g/cm3(Predicted) |
沸点 | 617.4±65.0 °C(Predicted) |
溶解度 | DMSO: ≥ 40 mg/mL |
酸度系数 | 10.15±0.29(Predicted) |
存储条件 | 2-8°C(protect from light) |
体外研究 | PU-WS13 is a Grp94 inhibitor, with an EC 50 of 0.22 μM. PU-WS13 also slightly suppresses Hsp90α, Hsp90β and Trap-1, with EC 50 s of 27.3, 41.8 and 7.3 μM, respectively. PU-WS13 (2.5-20 μM) shows no toxicity on two nonmalignant cell lines. PU-WS13 (15 μM) disrupts the circular architecture of HER2 at the plasma membrane of SKBr3 cells mediated through Grp94. PU-WS13 inhibits Grp94, and the inhibition induces apoptosis in and reduce the viability of HER2 overexpressing breast cancer cells. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.431 ml | 12.155 ml | 24.31 ml |
5 mM | 0.486 ml | 2.431 ml | 4.862 ml |
10 mM | 0.243 ml | 1.216 ml | 2.431 ml |
5 mM | 0.049 ml | 0.243 ml | 0.486 ml |
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