15291-76-6
银杏内酯 C(Ginkgolide C)
CAS: 15291-76-6
化学式: C20H24O11
| 中文名 | 银杏内酯 C |
| 英文名 | Ginkgolide C |
| 别名 | 银杏内酯C 杏内酯 C 银杏内酯 C 白果苦内酯 C 银杏内酯C(标准品) 7Β-二羟基银杏内酯A) 银杏内酯C(分析标准品) 银杏内酯 C, 来源于银杏 GINKGOLIDE C 银杏内酯C 白果苦内酯C,1Β,7Β-二羟基银杏内酯A 银杏内酯C(白果苦内酯C,1Β,7Β-二羟基银杏内酯A) |
| 英文别名 | bn52022 CGinkgolid Gingkolide C GINKGOLIDE C Ginkgolide C 1,7-DIHYDROXY-GINKGOLIDE A GinkgolideA,1,7-dihydroxy-, (1α,7β)- |
| CAS | 15291-76-6 |
| 化学式 | C20H24O11 |
| 分子量 | 440.4 |
| InChI | InChI=1/C20H24O11/c1-5-12(24)28-11-8(22)18-10-6(21)7(16(2,3)4)17(18)9(23)13(25)30-15(17)31-20(18,14(26)29-10)19(5,11)27/h5-11,15,21-23,27H,1-4H3/t5-,6-,7+,8?,9?,10-,11+,15+,17?,18?,19-,20+/m1/s1 |
| 密度 | 1.72±0.1 g/cm3(Predicted) |
| 熔点 | >3000 (dec) |
| 沸点 | 813.8±65.0 °C(Predicted) |
| 比旋光度 | D24 -14.7° (c = 1 in ethanol) |
| 闪点 | 291.4°C |
| 蒸汽压 | 1.15E-30mmHg at 25°C |
| 溶解度 | DMSO (微溶)，乙醇 (微溶，超声处理)，甲醇 (微溶，加热) |
| 折射率 | 1.671 |
| 酸度系数 | 10.88±0.70(Predicted) |
| 存储条件 | Sealed in dry,Store in freezer, under -20°C |
| 外观 | 整洁 |
| 颜色 | White to Off-White |
| 物化性质 | 白色结晶体，易溶于甲醇，来源于银杏叶。 |
| MDL号 | MFCD02094178 |
| 体外研究 | Ginkgolide C (3-100 μM) has no significant effect on 3T3-L1 cell viability, but suppresses adipogenesis in 3T3-L1 cells followling 24 h treatment. Ginkgolide C (10-100 μM) significantly suppresses lipid accumulation compared with the control group and also significantly promotes glycerol release in 3T3-L1 adipocytes. Ginkgolide C suppresses PPAR-α and PPAR-γ expression and decreases C/EBPα, C/EBPβ, and SREBP-1c expression in differentiated 3T3-L1 adipocytes. In addition, Ginkgolide C (3-100 μM) suppress adipogenesis-related protein (FAS, LPL, and aP2) and mRNA expression in a dose-dependent manner in differentiated 3T3-L1 adipocytes. Ginkgolide C (3-100 μM) also significantly promotes Sirt1 production and increases phosphorylation of AMPKα and ACC-1 in a concentration-dependent manner. Ginkgolide C (1, 10, 50, 100, 500 mM) significantly reduces the collagen (10 mg/mL)-stimulated rat platelet aggregation in a dose-dependent manner. Ginkgolide C (50, 100 mM) causes pro-MMP-9 (92-kDa) to form an activated MMP-9 (86-kDa) in collagen-stimulated platelets. |
| 安全术语 | S22 - 切勿吸入粉尘。 S24/25 - 避免与皮肤和眼睛接触。 |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10-21 |
| 海关编号 | 29322090 |
| 参考资料 展开查看 | 1. 冯如 李泽宏 袁红慧 等. 不同胁迫处理对银杏叶片萜内酯含量的影响[J]. 武汉工业学院学报 2017 036(001):34-38 53. 2. 江美芳,高崎,王丹丹.银杏酮酯片中萜内酯、黄酮苷整合溶出度的测定[J].中成药,2020,42(10):2716-2719. 3. Zhang, Wen, et al. "Diterpene ginkgolides protect against cerebral ischemia/reperfusion damage in rats by activating Nrf2 and CREB through PI3K/Akt signaling." Acta Pharmacologica Sinica 39.8 (2018): 1259-1272.https://doi.org/10.1038/aps.2017.149 4. [IF=5.064] Zhang Wen et al."Diterpene ginkgolides protect against cerebral ischemia/reperfusion damage in rats by activating Nrf2 and CREB through PI3K/Akt signaling."Acta Pharmacol Sin. 2018 Mar;39(8):1259-1272 5. [IF=3.935] Xingliang Niu et al."Hydrogen/deuterium exchange, a unique and effective method for MS fragmentation behavior elucidation of ginkgolides and its application to systematic research in Ginkgo biloba."J Pharmaceut Biomed. 2017 Feb;134:181 6. [IF=5.645] Ying Guo et al."Spatial prediction and delineation of Ginkgo biloba production areas under current and future climatic conditions."Ind Crop Prod. 2021 Aug;166:113444 7. [IF=3.935] Yongyi Li et al."Integrated molecular networking strategy enhance the accuracy and visualization of components identification: A case study of Ginkgo biloba leaf extract."J Pharmaceut Biomed. 2022 Feb;209:114523 |
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产品名: Ginkgolide C游离 去供应商网站查看 询盘CAS: 15291-76-6
产地: 北京
包装: 瓶
规格: YS147458-10mg
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库存: 一周左右
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提供多种规格现货供应
产品名: Ginkgolide C游离 去供应商网站查看 询盘CAS: 15291-76-6
产地: 北京
包装: 瓶
规格: YS147458-10mg
价格: 电话、微信、QQ、邮件
库存: 一周左右
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 索莱宝直销，欢迎来询
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