156161-89-6_化工百科

中文名	BQ-788 (sodium salt)
英文名	BQ-788 (sodium salt)
别名	BQ-788 钠盐化合物 T10595L
英文别名	BQ-788 BQ-788 SODIUM BQ-788 (sodium salt) N-[N-[N-[(2,6-Dimethyl-1-piperidinyl)carbonyl]- 2,6-Dimethylpiperidinecarbonyl-γ-Methyl-Leu-Nin-(Methoxycarbonyl)-D-Trp-D-Nle N-[(cis-2,6-Dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-D-norleucinesodiumsalt N-[N-[N-[(2,6-Dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl]-1-(methoxycarbonyl)-D-tryptophyl]-D-norleucine sodium salt, 2,6-Dimethylpiperidinecarbonyl-γ-Methyl-Leu-Nin-(Methoxycarbonyl)-D-Trp-D-Nle
CAS	156161-89-6
化学式	C34H50N5O7.Na
分子量	663.79
溶解度	乙腈: 0.3mg/ml
存储条件	-20°C
外观	固体
颜色	white
体外研究	BQ-788 potently and competitively inhibits 125 I-labeled ET-1 binding to ETB receptors in human Girrardi heart cells with an IC 50 of 1.2 nM, but only poorly inhibits the binding to ETA receptors in human neuro-blastoma cell line SK-N-MC cells (IC 50 , 1300 nM). BQ-788 shows no agonistic activity up to 10 μM and competitively inhibits thevasoconstriction induced by an ETB-selective agonist (pA2, 8.4). BQ-788 also inhibits several bioactivities of ET-1, such as bronchoconstriction, cell proliferation, and clearance of perfused ET-1.
体内研究	BQ-788 (3 mg/kg/h, i.v.) completely inhibits a pharmacological dose of ET-1- or sarafotoxin6c (0.5 nmol/kg, i.v.)-induced ETB receptor-mediated depressor, but not pressor responses in conscious rats. Furthermore, BQ-788 markedly increases the plasma concentration of ET-1, which is considered an index of potential ETB receptor blockade in vivo. In Dahl salt-sensitive hypertensive (DS) rats, BQ-788 (3 mg/kg/h, i.v.) increases blood pressure by about 20 mm Hg. It is reported that BQ-788 also inhibits ET-1-induced bronchoconstriction, tumor growth and lipopolysaccharide-induced organfailure. BQ 788 (3 mg/kg) results in an eightfold leftward shift in the ET-1 dose-response curve, suggesting a significant involvement of ETB dilator receptors. Mice are treated with 30 nmol BQ-788 by intraplantar, reduce mechanical hyperalgesia (47% and 42%), thermal hyperalgesia (68% and 76%), oedema (50% and 30%); myeloperoxidase activity (64% and 32%), and overt-pain like behaviours. Additionally, intraplantar treatment with clazosentan or BQ-788 decreases spinal (45% and 41%) and peripheral (47% and 47%) superoxide anion production as well as spinal (47% and 47%) and peripheral (33% and 54%) lipid peroxidation, respectively.
WGK Germany	3

156161-89-6 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	1.507 ml	7.533 ml	15.065 ml
5 mM	0.301 ml	1.507 ml	3.013 ml
10 mM	0.151 ml	0.753 ml	1.507 ml
5 mM	0.03 ml	0.151 ml	0.301 ml

最后更新：2024-01-02 23:10:35

156161-89-6 - 简介

BQ-788（钠盐）是一种化学物质，它的主要性质如下：

物理性质：BQ-788（钠盐）是一种白色结晶固体，在室温下可溶于水和一些有机溶剂。

化学性质：BQ-788（钠盐）是一种具有抗内皮素受体作用的化合物。

BQ-788（钠盐）的主要用途是研究内皮素生物学，特别是与内皮素B型受体（ETB受体）的相互作用。

BQ-788（钠盐）的制法一般是通过合成化学的方法得到的。具体的制法会涉及多个步骤和化合物之间的反应。

虽然BQ-788（钠盐）在科学研究中有广泛的应用，但要注意其安全使用。如若使用时，请遵循实验室安全操作规程，佩戴适当的防护装备，避免吸入、接触皮肤或进食。在使用前请查阅相关资料，了解其安全操作指南和危害性评估报告，以确保安全操作和储存。在处理废物时，应按照相关法规进行处理，以避免环境污染和危害。

最后更新：2024-04-09 01:59:58

上海吉至生化科技有限公司

现货供应

产品名: BQ-788 钠盐去供应商网站查看询盘
CAS: 156161-89-6
产地: 中国上海
包装: 10mg
规格: 98%
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产品描述: 中文名：BQ-788 钠盐英文名:BQ-788 sodium salt CAS:156161-89-6 规格:98% 产地:中国上海

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现货供应

产品名: BQ-788 sodium salt 去供应商网站查看询盘
CAS: 156161-89-6
产地: 上海
规格: B881970
价格: 5mg-3096,1mg-1427
库存: 7天内发货
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上海源叶生物科技有限公司

产品名: BQ-788 (sodium salt) 去供应商网站查看询盘
CAS: 156161-89-6
产地: 上海
规格: 98%
价格: 1mg 1500,5mg 3255,10mg 4650
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