中文名 | N,N,N',N'-四-(2-吡啶基甲基)乙二胺 |
英文名 | N,N,N',N'-tetrakis(2-pyridylmethyl) ethylenediamine |
别名 | N,N,N',N'-4(2-吡啶甲基)乙二胺 N,N,N',N'-四(2-吡啶甲基)乙二胺 N,N,N',N'-四-(2-吡啶基甲基)乙二 N,N,N',N'-四-(2-吡啶基甲基)乙二胺 N,N,N',N'-四KIS-(2-吡啶基甲基)乙二胺 N,N,N',N'-四(2-吡啶甲基)乙二胺,室温保存即可 1,2-乙烷二胺, N,N,N',N'-四(2-吡啶基甲基)- |
英文别名 | TPEN CS-960 TETRAKIS-(2-PYRIDYLMETHYL)ETHYLENEDIAMINE N,N,N',N'-TETRAKIS(2-PYRIDYLMETHYL)ETHYLENEDIAMINE N,N,N',N'-tetrakis(2-pyridylmethyl) ethylenediamine N,N,N',N'-tetrakis(2-pyridinylmethyl)-1,2-Ethanediamine 1,2-Ethanediamine, N,N,N',N'-tetrakis(2-pyridinylmethyl)- {2-[BIS(PYRIDIN-2-YLMETHYL)AMINO]ETHYL}BIS(PYRIDIN-2-YLMETHYL)AMINE |
CAS | 16858-02-9 |
化学式 | C26H28N6 |
分子量 | 424.54 |
InChI | InChI=1/C26H28N6/c1-5-13-27-23(9-1)19-31(20-24-10-2-6-14-28-24)17-18-32(21-25-11-3-7-15-29-25)22-26-12-4-8-16-30-26/h1-16H,17-22H2 |
密度 | 1.3893 (rough estimate) |
熔点 | 110-112°C |
沸点 | 530.56°C (rough estimate) |
闪点 | 281.7°C |
蒸汽压 | 8.14E-12mmHg at 25°C |
溶解度 | 溶于DMSO (高达10 mg/ml)。 |
折射率 | 1.4570 (estimate) |
酸度系数 | 5.19±0.12(Predicted) |
存储条件 | Sealed in dry,2-8°C |
稳定性 | 自供应购买之日起稳定2年。DMSO中的溶液可以在-20 °C下保存长达3个月。 |
外观 | 棕褐色固体 |
颜色 | Off-white or tan |
BRN | 4211982 |
体外研究 | Heavy metal chelator TPEN attenuates fura-2 fluorescence changes induced by cadmium, mercury and methylmercury. TPEN, a cell-permeable chelator for heavy metal cations with a low affinity for Ca 2+ . In cells stimulated with 10 or 30 μM cadmium chloride, the addition of TPEN at 3 hr after exposure significantly decreases the elevated fura-2 fluorescence ratio to the basal levels within 10 min (119.6±2.4% or 109±1.5% decrease in ΔRatio (F340/F380) induced by 10 or 30 μM cadmium chloride, respectively), suggesting that a cadmium chloride-induced increase in the fura-2 fluorescence ratio is dependent on an increase in intracellular heavy metal cations but not intracellular Ca 2+ . TPEN is a metal chelator, which targets colon cancer cells through redox cycling of copper. TPEN reduces cell viability in a dose- and time-dependent manner. TPEN-induced cell death is also dependent on the redox cycling of copper since the copper chelator neocuproine inhibited DNA damage and reduced pChk1, γ-H2AX, and ATM protein expression. Cell death by low TPEN concentrations, involved ATM/ATR signaling in all 3 cell lines, since pre-incubation with specific inhibitors of ATM and DNA-PK led to the recovery of cells from TPEN-induced DNA damage. |
危险品标志 | Xi - 刺激性物品 |
风险术语 | 36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
安全术语 | S26 - 不慎与眼睛接触后,请立即用大量清水冲洗并征求医生意见。 S36 - 穿戴适当的防护服。 |
WGK Germany | 3 |
FLUKA BRAND F CODES | 8-10-23 |
海关编号 | 29333990 |
上游原料 | N,N'-BIS-2-PYRIDYLMETHYL ETHYLENEDIAMINE 乙二胺 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.355 ml | 11.777 ml | 23.555 ml |
5 mM | 0.471 ml | 2.355 ml | 4.711 ml |
10 mM | 0.236 ml | 1.178 ml | 2.355 ml |
5 mM | 0.047 ml | 0.236 ml | 0.471 ml |
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