中文名 | NCT-501 |
英文名 | NCT-501 |
别名 | ALDH1A1抑制剂(NCT-501) |
英文别名 | NCT-501 CS-2069 1H-Purine-2,6-dione, 8-[[4-(cyclopropylcarbonyl)-1-piperazinyl]methyl]-3,7-dihydro-1,3-dimethyl-7-(3-methylbutyl)- |
CAS | 1802088-50-1 |
化学式 | C21H32N6O3 |
分子量 | 416.52 |
密度 | 1.37±0.1 g/cm3(Predicted) |
沸点 | 627.3±65.0 °C(Predicted) |
溶解度 | DMSO: ≥ 28 mg/mL |
酸度系数 | 5.26±0.10(Predicted) |
存储条件 | -20℃ |
体外研究 | NCT-501 shows a 16% decrease in the Cal-27 CisR cell line at 20 nM concentration, though the difference was not statistically significant. |
体内研究 | NCT-501 (100 µg/animal; i.t.; every alternate day for 20 days) shows a 78% inhibition in tumor growth in Cal-27 CisR derived xenografts. Animal Model: 5-6 weeks old male Hsd: Athymic Nude-Foxn1nu (immuno-deficient-mice bearing Cal-27 CisR cells) Dosage: 100µg/animal Administration: Intra-tumorally (i.t); every alternate day for 20 days Result: Showed a 78% inhibition in tumor growth in Cal-27 CisR derived xenografts. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.401 ml | 12.004 ml | 24.009 ml |
5 mM | 0.48 ml | 2.401 ml | 4.802 ml |
10 mM | 0.24 ml | 1.2 ml | 2.401 ml |
5 mM | 0.048 ml | 0.24 ml | 0.48 ml |
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