中文名 | 孕烯醇酮硫酸钠盐 |
英文名 | Pregnenolone monosulfate sodium salt |
别名 | 孕烯醇硫酸盐 孕烯醇酮硫酸钠盐 化合物 T16574 未标记的孕烯醇硫酸盐 |
英文别名 | PREGNENOLONE SULFATE SODIUM PREGNENOLONE SULFATE SODIUM SALT Pregnenolone monosulfate sodium salt 3-HYDROXYPREGN-5-EN-20-ONE SULFATE SODIUM SALT (3β)-3-(Sulfooxy)-pregn-5-en-20-one sodium salt 3B-HYDROXY-5-PREGNEN-20-ONE 3-SULFATE SODIUM SALT 3-BETA-HYDROXY-5-PREGNEN-20-ONE 3-SULPHATE, SODIUM SALT |
CAS | 1852-38-6 |
化学式 | C21H31NaO5S |
分子量 | 418.52 |
熔点 | 192°C(lit.) |
溶解度 | 甲醇和水: 1.93 mg/mL |
存储条件 | -20°C |
物化性质 | 生物活性 Pregnenolone monosulfate sodium salt (3β-Hydroxy-5-pregnen-20-one monosulfate sodium salt) 是一种功能强大的神经甾体,是包括甾体酮在内的各种甾体激素的主要前体。Pregnenolone monosulfate sodium salt 是大麻素 CB1 受体的信号传导特异性抑制剂,抑制由 CB1 受体介导的四氢大麻酚 (THC) 的作用。Pregnenolone monosulfate sodium salt 可以保护大脑免受大麻毒性的侵袭。 |
靶点 | CB1 Human Endogenous Metabolite |
体外研究 | CB1 receptor stimulation increases brain Pregnenolone levels, which in turn exerts a negative feedback on the activity of the CB1 receptor antagonizing most of the known behavioral and somatic effects of THC. Pregnenolone likely acts as a signaling-specific negative allosteric modulator binding to a site distinct from that occupied by orthosteric ligands. Pregnenolone does not modify agonist binding but only agonist efficacy. The effect of THC is significantly attenuated when slices are pre-treated with Pregnenolone 100 nM (15.1±1.8 % of inhibition). These effects are likely due to a pre-synaptic action of Pregnenolone. Thus, Pregnenolone blocks the increase in paired-pulse ratio (PPR) induced by THC but does not modify either the amplitude or the decay time of miniature EPSC (mEPSC). |
体内研究 | Pregnenolone administration (2-6 mg/kg) blocks THC-induced food-intake in Wistar rats and in C57BL/6N mice, and blunts the memory impairment induced by THC in mice, but it does not modify these behaviors per se . Injections of Pregnenolone (2 and 4mg/kg) before each self-administration session reduce the intake of WIN 55,212-2 and reduce the break-point in a progressive ratio schedule. |
WGK Germany | 3 |
微信搜索化工百科或扫描下方二维码,添加化工百科小程序,随时随地查信息!