18Β-甘草次酸标准品
甘草亭酸(18-Beta-Glycyrrhetinic acid)
CAS: 471-53-4
化学式: C30H46O4
| 中文名 | 甘草亭酸 |
| 英文名 | 18-Beta-Glycyrrhetinic acid |
| 别名 | 甘珀酸 甘草次酸 甘草亭酸 beta-甘草亭酸 BETA-甘草次酸 甘草次酸, 来源于甘草 18Β-甘草次酸标准品 18 BETA 甘草次酸 甘草次酸(18-Β-甘草次酸) 3β-羟基-11-氧-12-齐墩果烯-30-酸 (3β,20β)-3-羟基-11-氧代-齐墩果-12-烯-29-酸 (3B,20B)-3-羟基-11-氧代-齐墩果-12-烯-29-酸 |
| 英文别名 | Enoxolone Glycyrrheticacid Glycyrrhetic acid Glycyrrhetinic acid 18B-glycyrrhetinic acid alpha-glycyrrhetinicacid 18-beta-glycyrrheticacid 18beta-Glycyrrhetinic acid 18-Beta-Glycyrrhetinic acid GLYCYRRHETINIC ACID, 18B-(P) Aloe Vera, Freeze Dried Powder 3-Hydroxy-11-oxo-12-oleanen-30-oicacid 3-beta-hydroxy-11-oxoolean-12-en-30-oicacid 3-beta-hydroxy-11-oxo-olean-12-en-30-oicaci 3.beta.-Hydroxy-11-oxo-12-oleanen-30-oicacid (20S)-3β-Hydroxy-11-oxo-5α-olean-12-en-29-oic acid Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3b,20b)- 3-hydroxy-11-oxo-,(3beta,20beta)-olean-12-en-29-oicaci (3beta,5xi,9xi)-3-hydroxy-11-oxoolean-12-en-30-oic acid 3-hydroxy-11-oxo-,(3.beta.,20.beta.)-Olean-12-en-29-oicacid Enoxolone, 3β-Hydroxy-11-oxo-18β,20β-olean-12-en-29-oic acid |
| CAS | 471-53-4 |
| EINECS | 207-444-6 |
| 化学式 | C30H46O4 |
| 分子量 | 470.69 |
| InChI | InChI=1/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)/t19-,21?,22-,23?,26+,27-,28-,29+,30+/m0/s1 |
| 密度 | 0.9967 (rough estimate) |
| 熔点 | 292-295°C(lit.) |
| 沸点 | 492.11°C (rough estimate) |
| 比旋光度 | 165 º (c=1, CHCl3,on dry ba) |
| 闪点 | 323.7°C |
| 水溶性 | SOLUBLE IN ACETIC ACID |
| 蒸汽压 | 10-220Pa at 20-50℃ |
| 溶解度 | 几乎不溶于水，溶于乙醇，微溶于二氯甲烷。 |
| 折射率 | 162 ° (C=1, MeOH) |
| 酸度系数 | pKa 5.56±0.1 (Uncertain) |
| 存储条件 | 2-8°C |
| 外观 | 结晶性粉末 |
| 颜色 | White to off-white |
| Merck | 14,3590 |
| BRN | 2229654 |
| 物化性质 | 由甘草酸-ff两个分子的葡萄糖醛酸组成的苷。白色结晶性粉末，味甜，甜度约为蔗糖的200倍。其甜味与蔗糖等甜味剂不同，入口后要略过片刻才有甜味感，但留存时间长。少量甘草苷与蔗糖并用可少用20%蔗糖而甜度不变。虽无香气，但有增香效能。熔点(分解)220℃。水溶液呈弱酸性，可由酸的作用 |
| MDL号 | MFCD00003706 |
| 危险品标志 | Xn - 有害物品 |
| 风险术语 | R22 - 吞食有害。 R36 - 刺激眼睛。 |
| 安全术语 | S22 - 切勿吸入粉尘。 S24/25 - 避免与皮肤和眼睛接触。 |
| WGK Germany | 3 |
| RTECS | RK0180000 |
| 海关编号 | 29189900 |
| 上游原料 | 乙醇 乙醇溶液 蔗糖 甘草酸 甘草 |
| 下游产品 | 硬脂醇甘草亭酸酯 |
| 参考资料 展开查看 | 1. 顾薇 毛春芹 袁晓莉 等. HPLC-ELSD法精确定量大鼠胆汁中牛磺胆酸的方法研究[J]. 生物技术世界 2015 000(011):17-18. 2. 王守云 霍韬光 封聪 等. LC-MS/MS测定小鼠肝脏中甘草次酸含量[J]. 化学研究 2016 27(004):429-432. 3. 封聪 霍韬光 王守云 等. LC-MS/MS测定小鼠肾脏中甘草次酸的含量[J]. 化学研究 2016(3):318-322. 4. 王胜超 张振凌 于文娜 等. 人中黄的HPLC指纹图谱及炮制机理初探[J]. 中药材 2017(05):83-87. 5. 董月柳, 李雪莲, 陈江鹏,等. 多成分环境下甘草次酸肠吸收行为的研究[J]. 中草药, 2017(16). 6. 方莹,张颖花,霍韬光,何俏,侯明山,姜泓,康廷国.微透析-HPLC测定甘草次酸对雄黄染毒小鼠海马细胞外液中Cys和Hcy含量的影响[J].化学研究,2016,27(02):202-205. 7. 王立英, 刘雨萌, 金元宝,等. 甘草次酸对谷氨酸所致PC12细胞损伤的保护作用及其机理[J]. 华西药学杂志, 2013(04):24-27. 8. 王艳蕾, 贾雨涵, 赵嘉涵,等. 甘草次酸对雄黄致小鼠海马突触超微结构损伤的改善作用[J]. 吉林大学学报(医学版), 2019, 045(002):268-272. 9. 盖亚男, 汪琼, 陈剑,等. 盾叶薯蓣4种皂苷含量的LC-MS/MS快速测定法[J]. 现代中药研究与实践, 2017(02):54-56. 10. 王泽 慈小燕 崔涛 魏滋鸿 张洪兵 刘睿 李亚卓 伊秀林 张铁军 谷元 武卫党 刘昌孝.不同药性成分对OAT4、URAT1抑制作用及对急性高尿酸血症小鼠血尿酸水平的影响[J].中草药 2019 50(05):1157-1163. 11. 仲金秋, 曹玉珠, 徐宏江,等. 甘草酸二铵改善ConA致小鼠肝损伤的作用研究[J]. 天然产物研究与开发, 2018, 30(12):60-68. 12. 王胜超 张振凌 刘艳 等. 人中黄炮制前后6种化学成分的含量变化及其质量评价[J]. 中国实验方剂学杂志 2017 023(009):11-16. 13. 程丽娜, 曹世杰, 曲明,等. 甘草主要成分改善L6大鼠成肌细胞胰岛素抵抗的机制[J]. 中国实验方剂学杂志, 2020(4). 14. 纪万里,周泽华,王婷婷,安叡,梁琨,王新宏.基于UPLC-LTQ-Orbitrap-MS方法分析半夏泻心汤化学成分[J].药物分析杂志,2020,40(10):1736-1750. 15. Tao, Y, Huang, S, Yan, J, Cai, B. A reliable LC–MS/MS method for the quantification of five bioactive saponins of crude and processed Bupleurum scorzonerifolium in rat plasma and its application to a pharmacokinetic study. Biomedical Chromatography. 2019; 16. Yi Tao, Dandan Su, Weidong Li, Baochang Cai, Pharmacokinetic comparisons of six components from raw and vinegar-processed Daphne genkwa aqueous extracts following oral administration in rats by employing UHPLC–MS/MS approaches, Journal of Chromatography B, 17. Tao-Guang, H. U. O., et al. "Liver metabonomics study on the protective effect of glycyrrhetinic acid against realgar-induced liver injury." Chinese journal of natural medicines 18.2 (2020): 138-147.https://doi.org/10.1016/S1875-5364(20)30014-5 18. Tao, Yi, et al. "Development and validation of an UHPLC–MS/MS approach for simultaneous quantification of five bioactive saponins in rat plasma: Application to a comparative pharmacokinetic study of aqueous extracts of raw and salt-processed Achyranthes bi 19. Tao, Yi, et al. "Determination of major components from Radix Achyranthes bidentate using ultra high performance liquid chromatography with triple quadrupole tandem mass spectrometry and an evaluation of their anti‐osteoporosis effect in vitro." Journal of 20. Yi Tao, Surun Huang, Guangming Yang, Weidong Li, Baochang Cai,A simple and sensitive LC–MS/MS approach for simultaneous quantification of six bioactive compounds in rats following oral administration of aqueous extract and ultrafine powder of Astragalus p 21. Tao, Y, Jiang, E, Yan, J, Cai, B. A biochemometrics strategy for tracing diuretic components of crude and processed Alisma orientale based on quantitative determination and pharmacological evaluation. Biomedical Chromatography. 2020; 34:e4744. https://doi. 22. Tao, Yi, et al. "Comparative pharmacokinetic analysis of extracts of crude and wine-processed Dipsacus asper in rats by a sensitive ultra performance liquid chromatography–tandem mass spectrometry approach." Journal of Chromatography B 1036 (2016): 33-41.h 23. [IF=5.64] Wu Dousheng et al."Oleanolic Acid Induces the Type III Secretion System of Ralstonia solanacearum."Front Microbiol. 2015 Dec;0:1466 24. [IF=4.36] Taoguang Huo et al."Plasma metabolomics study of the hepatoprotective effect of glycyrrhetinic acid on realgar-induced sub-chronic hepatotoxicity in mice via 1H NMR analysis."J Ethnopharmacol. 2017 Aug;208:36 25. [IF=3.205] Zhuangzhuang Li et al."Simultaneous quantification of fifteen compounds in rat plasma by LC-MS/MS and its application to a pharmacokinetic study of Chaihu-Guizhi decoction."J Chromatogr B. 2019 Jan;1105:15 26. [IF=10.479] Jing Guo et al."Gut microbiota and host Cyp450s co-contribute to pharmacokinetic variability in mice with non-alcoholic steatohepatitis: Effects vary from drug to drug."J Adv Res. 2021 Oct;: 27. [IF=4.749] Bin Wei et al."Highly Selective Entrapment of His-Tagged Enzymes on Superparamagnetic Zirconium-Based MOFs with Robust Renewability to Enhance pH and Thermal Stability."Acs Biomater Sci Eng. 2021;7(8):3727–3736 28. [IF=4.36] Li Lin et al."Study on the alleviation of Fengshi Gutong capsule on rheumatoid arthritis through integrating network pharmacology and experimental exploration."J Ethnopharmacol. 2021 Nov;280:114471 29. [IF=3.935] Zhengchao Ji et al."Global identification and quantitative analysis of representative components of Xin-Nao-Kang Capsule, a traditional Chinese medicinal formula, by UHPLC-Q-TOF-MS and UHPLC-TQ-MS."J Pharmaceut Biomed. 2021 May;198:114002 30. [IF=3.69] Qian Zhang et al."Qishen Granule alleviates endoplasmic reticulum stress-induced myocardial apoptosis through IRE-1-CRYAB pathway in myocardial ischemia."J Ethnopharmacol. 2020 Apr;252:112573 31. [IF=3.365] Tao Yang et al."Protection function of 18β-glycyrrhetinic acid on rats with high-altitude pulmonary hypertension based on 1H NMR metabonomics technology."Anal Biochem. 2021 Oct;631:114342 32. [IF=3.361] Dan-Ni Feng et al."Green synthesis and characterization of gold nanoparticles and their application for the rapid detection of glycyrrhizin with immunochromatographic strips."Rsc Adv. 2021 Jul;11(39):23851-23859 33. [IF=3] Tao-Guang HUO et al."Liver metabonomics study on the protective effect of glycyrrhetinic acid against realgar-induced liver injury."Chin J Nat Medicines. 2020 Feb;18:138 34. [IF=2.629] Li Tingting et al."Quality Assessment of Licorice Based on Quantitative Analysis of Multicomponents by Single Marker Combined with HPLC Fingerprint."Evid-Based Compl Alt. 2021;2021:8834826 35. [IF=1.902] Yi Tao et al."A reliable LC–MS/MS method for the quantification of five bioactive saponins of crude and processed Bupleurum scorzonerifolium in rat plasma and its application to a pharmacokinetic study."Biomed Chromatogr. 2019 Sep;33(9):e4570 |
18Β-甘草次酸标准品 - 简介
甘草亭酸，又称苯甲酸，是一种有机化合物。下面是关于甘草亭酸的性质、用途、制法和安全信息的介绍：
性质：
甘草亭酸是一种无色结晶固体，有特殊的芳香气味。它可溶于热水、乙醇、醚等有机溶剂，微溶于冷水。甘草亭酸具有一定的腐蚀性。
用途：
甘草亭酸在化工领域有广泛的应用。在有机合成中，甘草亭酸可以作为重要的反应中间体。
制法：
甘草亭酸一般通过苯甲醇与氧气氧化反应而制得。首先将苯甲醇与氧气通入反应器中，通过催化剂的作用，进行氧化反应，生成甘草亭酸。
安全信息：
甘草亭酸在正常使用条件下一般是安全的。应将甘草亭酸储存在干燥、通风良好的地方，远离火源和氧化剂。在使用时应戴好防护手套、护目镜等个人防护装备，避免吸入其气体。
性质：
甘草亭酸是一种无色结晶固体，有特殊的芳香气味。它可溶于热水、乙醇、醚等有机溶剂，微溶于冷水。甘草亭酸具有一定的腐蚀性。
用途：
甘草亭酸在化工领域有广泛的应用。在有机合成中，甘草亭酸可以作为重要的反应中间体。
制法：
甘草亭酸一般通过苯甲醇与氧气氧化反应而制得。首先将苯甲醇与氧气通入反应器中，通过催化剂的作用，进行氧化反应，生成甘草亭酸。
安全信息：
甘草亭酸在正常使用条件下一般是安全的。应将甘草亭酸储存在干燥、通风良好的地方，远离火源和氧化剂。在使用时应戴好防护手套、护目镜等个人防护装备，避免吸入其气体。
最后更新：2024-04-09 21:11:58
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