中文名 | Capromorelin Tartrate |
英文名 | Capromorelin Tartrate |
别名 | 酒石酸卡莫瑞林 卡普瑞林酒石酸盐 卡普瑞林L-酒石酸盐 |
英文别名 | CS-2136 CP 424391-18 CP-424391 tartrate CP-424391 TARTRATE CaproMorelin Tartrate Capromorelin Tartrate Capromorelin tartrate (CP-424,391) |
CAS | 193273-69-7 |
化学式 | C32H41N5O10 |
分子量 | 655.69544 |
熔点 | >150oC (dec.) |
溶解度 | DMSO (微溶) 、甲醇 (微溶) |
存储条件 | Hygroscopic, -20°C Freezer, Under inert atmosphere |
稳定性 | 吸湿性 |
外观 | 固体 |
颜色 | White to Light Yellow |
体外研究 | Capromorelin stimulates GH release in rat pituitary cell cultures with EC 50 of 3 nM. |
体内研究 | Dogs receiving capromorelin (30 mg/mL) have food consumption that is significantly greater than dogs treated with placebo. All dogs in the capromorelin group gain weight by 0.52 kg, more than that of placebo group. Capromorelin shows enhanced intestinal absorption in rodent models and exhibits superior pharmacokinetic properties, including high bioavailabilities in two animal species [F(rat)=65%, F(dog)=44%]. Capromorelin stimulates GH release in anesthesized rat model, with ED 50 of 0.05 mg/kg iv. |
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