19870-46-3_化工百科

中文名	1,5-二咖啡酰奎宁酸
英文名	1,5-Dicaffeoylquinic acid
别名	化合物GNE9605 1,3-二咖啡酰奎宁酸 1,5-二咖啡酰奎宁酸 1,3-二咖啡酰奎宁酸,对照品, 1,3-二咖啡酰奎宁酸 19870-46-3 (1S,3R,4R,5R)-1,3-O-二咖啡酰奎宁酸 1,5-二咖啡酰奎宁酸(洋蓟酸,菜蓟素,朝蓟素,朝鲜蓟酸,1,5-O-二咖啡酰奎宁酸)
英文别名	19870-46-3 CYNARIN 1,5-Dicaffeoylquinic acid 1,3-Dicaffeoylquinic acid Dicaffeoylquinic Acid, 1,5- 1,5-di-O-Caffeoylquinic acid (1S,3R,4R,5R)-1,3-Bis[3-(3,4-dihydroxyphenyl)acryloyloxy]-4,5-dihydroxycyclohexanecarboxylic acid (1S,3R,4R,5R)-1,3-bis[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]-4,5-dihydroxycyclohexane-1-carboxylicaci (1S,3R,4R,5R)-1,3-bis[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]-4,5-dihydroxycyclohexane-1-carboxylic acid Cyclohexanecarboxylic acid, 1,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxy-, (1S,3R,4R,5R)-
CAS	19870-46-3
EINECS	214-655-7
化学式	C25H24O12
分子量	516.45
密度	1?+-.0.1 g/cm3(Predicted)
沸点	819.9±65.0 °C(Predicted)
溶解度	可溶5mg/mL，澄清，无色至浅黄色
酸度系数	2.50±0.50(Predicted)
存储条件	Keep in dark place,Sealed in dry,2-8°C
外观	整洁
颜色	white to off-white
物化性质	白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于洋蓟叶，朝鲜蓟，森林千里光全草、金银花。
MDL号	MFCD13196505
体外研究	1,3-Dicaffeoylquinic acid shows increased neuronal cell viability against Aβ(42) toxicity in a concentration-dependent manner in neurons. 1,3-Dicaffeoylquinic acid activates both phosphoinositide 3-kinase (PI3K)/Akt and extracellular regulated protein kinase 1/2 (Erk1/2) with stimulating their upstream tyrosine kinase A (Trk A). 1,3-Dicaffeoylquinic acid's anti-apoptotic potential is related to the enhanced inactivating phosphorylation of glycogen synthase kinase 3β (GSK3β) and the modulation of expression of apoptosis-related protein Bcl-2/Bax. 1,3-Dicaffeoylquinic acid (10 μM, 20 μM, 50 μM, and 100 μM) significantly increases cell viablity before OGD/reperfusion, and prevents the depletion of GSH under OGD/reperfusion insult. 1,3-Dicaffeoylquinic acid induces nuclear translocation of Nrf2 in OGD/reperfusion treated astrocytes, and induces increased GCL activity, and the effect is lost in Nrf2 siRNA-transfected cells.
体内研究	1,3-Dicaffeoylquinic acid (32.0 mg/kg, p.o.) and 1-O-ABL are absorbed very quickly in Wistar rats. The maximum plasma concentrations for 1,3-Dicaffeoylquinic acid and 1-O-ABL are 44.5 ± 7.1 and 19.1 ± 6.9 ng/mL, respectively.
WGK Germany	3
参考资料展开查看	1. 杜蓉, 任力, 张孟佑. 苍耳子炒制前后水煎液中酚酸性成分含量比较[J]. 中国药师, 2016(2):247-250,共4页. 2. 闫征, 吴寒, 黄午阳,等. 杀青工艺对蓝莓叶茶活性成分及其抗氧化性能的影响[J]. 安徽农业科学, 2019. 3. Yossa Nzeuwa, Irma Belinda, et al. "Comparison of the origin and phenolic contents of Lycium ruthenicum Murr. by high‐performance liquid chromatography fingerprinting combined with quadrupole time‐of‐flight mass spectrometry and chemometrics." Journal of s 4. [IF=3.046] Menglin Wei et al."Protective effects of a Chotosan Fraction and its active components on β-amyloid-induced neurotoxicity."Neurosci Lett. 2016 Mar;617:143 5. [IF=3.645] Lewen Xiong et al."Study on phenolic acids of Lonicerae japonicae Flos based on ultrahigh performance liquid chromatography-tandem mass spectrometry combined with multivariate statistical analysis."JOURNAL OF SEPARATION SCIENCE

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产品描述: 中文名：1,5-二咖啡酰奎宁酸英文名:1,5-Dicaffeoylquinic acid CAS:19870-46-3 规格:分析对照品,HPLC≥98% 产更多

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CAS: 19870-46-3
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