白色结晶或结晶性粉末。无气味,可溶于热的浓硫酸、甘油、碱溶液、乙酸钠和磷酸钠溶液。几乎不溶于水,不溶于乙醇和乙醚。加热至400℃以上分解出氢氰酸而不熔化,因此不能受强热。
取干燥鸡粪悬浮于24倍量水中,加入适量氢氧化钙后静置。沉淀完全后分出上清液,沉淀中再加水,用硝酸调节pH值至3,静置至沉淀完全。分出上清液,沉淀物再悬浮在水中,以氢氧化钙调节pH值至12~12.5,过滤后滤液以硝酸调pH值至3,析出物过滤、干燥后即为尿酸粗品。
可用于测定尿酸酶和钨酸盐的试剂。尿酸及其衍生物对皮肤无副作用,在化妆品中使用有多种调理功能。有显著保湿性能,能治疗皮肤功能失调,有抗氧化性,能延缓皮肤衰老和防止皮肤癌。在护发品中使用可抑制头屑。
中文名 | 尿酸,标准液 |
英文名 | Uric acid |
别名 | 尿酸 三氧化嘌呤 尿酸,标准液 尿酸,参比液 8-三羟基嘌呤 尿酸(标准品) 2,6,8-三羟基嘌呤 2,6,8,-三羟基嘌呤 2,6,8,-三羟基尿杂环 7,9-二氢-2,6,8(3H)三酮-1H-嘌呤 |
英文别名 | Uric acid 2,6,8-Trioxypurine 2,6,8-Trioxopurine 1H-Purine-2,6,8-triol PURINE-2,6,8(1H,3H,9H)-TRIONE Purine-3,6,8(1H,3H,9H)-trione 8(3h)-trione,7,9-dihydro-1h-purine-6 7,9-Dihydro-1H-purine-2,6,8(3H)-trione 6,8(3H)-trione,7,9-dihydro-1H-Purine-2 1H-Purine-2,6,8(3H)-trione,7,9-dihydro- 1H-Purine-2,6,8(3H)-trione, 7,9-dihydro- |
CAS | 69-93-2 |
EINECS | 200-720-7 |
化学式 | C5H4N4O3 |
分子量 | 168.11 |
InChI | InChI=1/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12) |
密度 | 1,9 g/cm3 |
熔点 | >300 °C (lit.) |
沸点 | 297.02°C (rough estimate) |
闪点 | 475.7°C |
水溶性 | Soluble in 1M sodium hydroxide solution. Slightly soluble in water. Insoluble in ether and alcohol. |
蒸汽压 | 2.63E-31mmHg at 25°C |
溶解度 | 水基 (微溶加热) |
折射率 | 1.9900 (estimate) |
酸度系数 | 3.89(at 12℃) |
存储条件 | Sealed in dry,2-8°C |
稳定性 | 稳定。与酸、碱、氧化剂不相容。 |
外观 | 结晶 |
颜色 | White to off-white |
气味 | Odorless |
Merck | 14,9875 |
BRN | 156158 |
MDL号 | MFCD00005712 |
体外研究 | Uric acid is an endogenous antioxidant that scavenges reactive oxygen species (ROS) including singlet oxygen, oxygen radicals, and peroxynitrite. Incubation with indomethacin significantly increases malondialdehyde (MDA) levels in Caco-2 cells compare to those not treated indomethacin. Incubation with both indomethacin and Uric acid significantly decreases MDA levels compare to those grown in the presence of indomethacin alone. Co-treatment of cells with indomethacin and Uric acid significantly decreases ROS levels compare to those in cells incubated with indomethacin alone. Cell viability in Caco-2 cells treated with both indomethacin and Uric acid is higher than that in cells treated with indomethacin alone. Uric acid has a protective effect on indomethacin-induced intestinal cell changes through its antioxidant activity. |
体内研究 | When mice treated with indomethacin are concurrently administered Uric acid orally, ulcer areas are significantly reduced, in a Uric acid dose-dependent manner. Indomethacin increases the ratio of crypt depth to villous height in the ileum, while the ratio is significantly lower when mice are concurrently administered Uric acid orally. Administration of indomethacin also increases the histopathological score of tissue damage in the small intestine, while mice concurrently administered Uric acid orally has a significantly lower histopathological score. The ileal levels of malondialdehyde (MDA) in indomethacin-induced enteropathy model mice orally administered Uric acid are also significantly lower than the levels in mice administered indomethacin alone. |
危险品标志 | Xi - 刺激性物品 |
风险术语 | R33 - 有累积效应的危险品。 R36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
安全术语 | S24/25 - 避免与皮肤和眼睛接触。 S36 - 穿戴适当的防护服。 S26 - 不慎与眼睛接触后,请立即用大量清水冲洗并征求医生意见。 |
WGK Germany | 3 |
RTECS | YU7050080 |
TSCA | Yes |
海关编号 | 29339900 |
下游产品 | 三聚氰胺一酰胺 |
参考资料 展开查看 | 1. 李鹏威, 张尧, 李庆莲,等. 基于三维石墨烯-普鲁士蓝构建电化学酶传感器用于尿酸的灵敏检测[J]. 分析化学, 2019, 047(012):1938-1945. 2. 万冬梅, 郑鹄志, 隆异娟,等. 基于木瓜蛋白酶过氧化物模拟酶活性的尿酸检测[J]. 分析试验室, 2017, 10(v.36):22-25. 3. 张静, 杨平荣, 王燕萍,等. 高效液相色谱法同时测定玫瑰花等多种食物中尿酸及4种嘌呤含量[J]. 兰州大学学报(医学版), 2019(3):28-33. 4. 李晶,刘雯,陈超,虞金宝.车前三个不同部位中主要化学成分含量差异及其黄嘌呤氧化酶体外抑制作用比较[J].实用中西医结合临床,2018,18(07):174-176. 5. 梁玲玲 康红. 两种铀配合物对生物分子的荧光标记性质研究[J]. 化学与生物工程 2019(11). 6. 陈尚龙, 刘恩岐, 陈安徽,等. 应用体外全仿生模型初步分析2种富硒产品中硒形态及生物可给性[J]. 食品科学, 2018, 039(004):225-232. 7. 洪泽翰, 吴婉仪, 李璐,等. 不同大分子乳化剂构建番茄红素纳米乳液的体外消化规律比较[J]. 食品科学, 2019, 40(10):9-15. 8. 陈尚龙, 陈安徽, 刘辉,等. 应用消化系统全仿生模型分析酸奶发酵对钙形态的影响[J]. 农业工程学报, 2018, v.34;No.332(05):297-302. 9. Wang, X. Y. , et al. "A novel ratiometric fluorescent probe for the detection of uric acid in human blood based on H 2 O 2 -mediated fluorescence quenching of gold/silver nanoclusters." Talanta 191(2019):46-53. 10. Wang, Li-Ming, et al. "1H NMR and UHPLC/Q-Orbitrap-MS-Based metabolomics combined with 16S rRNA gut microbiota analysis revealed the potential regulation mechanism of nuciferine in hyperuricemia rats." Journal of Agricultural and Food Chemistry 68.47 (2020 11. Xiaoyu Yang, Lu Chen, Xiuxiu Xiong, Yun Shu, Dangqin Jin, Yang Zang, Wei Wang, Qin Xu, Xiao-Ya Hu, Molecularly imprinted polymers and PEG double engineered perovskite: an efficient platform for constructing aqueous solution feasible photoelectrochemical se 12. Yun, Yu, et al. "Excretory function of intestinal tract enhanced in kidney impaired rats caused by adenine." The Scientific World Journal 2016 (2016).https://doi.org/10.1155/2016/2695718 13. [IF=6.057] Xiao-yan Wang et al."A novel ratiometric fluorescent probe for the detection of uric acid in human blood based on H2O2-mediated fluorescence quenching of gold/silver nanoclusters."Talanta. 2019 Jan;191:46 14. [IF=5.833] Mei Ling et al."Non-enzymatic sensing of glucose and hydrogen peroxide using a glassy carbon electrode modified with a nanocomposite consisting of nanoporous copper, carbon black and nafion."Microchim Acta. 2016 Apr;183(4):1359-1365 15. [IF=5.833] Chen Dandan et al."Electrochemical determination of dopamine using a glassy carbon electrode modified with a nanocomposite consisting of nanoporous platinum-yttrium and graphene."Microchim Acta. 2018 Feb;185(2):1-7 16. [IF=7.46] Xiaoyu Yang et al."Molecularly imprinted polymers and PEG double engineered perovskite: an efficient platform for constructing aqueous solution feasible photoelectrochemical sensor."Sensor Actuat B-Chem. 2020 Feb;304:127321 17. [IF=6.331] Xiao Liang et al."Urate oxidase loaded in PCN-222(Fe) with peroxidase-like activity for colorimetric detection of uric acid."J Mater Chem B. 2021 Sep;9(34):6811-6817 18. [IF=6.057] Lu Chen et al."A highly-specific photoelectrochemical platform based on carbon nanodots and polymers functionalized organic-inorganic perovskite for cholesterol sensing."Talanta. 2021 Apr;225:122050 19. [IF=5.279] Li-Ming Wang et al."1H NMR and UHPLC/Q-Orbitrap-MS-Based Metabolomics Combined with 16S rRNA Gut Microbiota Analysis Revealed the Potential Regulation Mechanism of Nuciferine in Hyperuricemia Rats."J Agr Food Chem. 2020;68(47):14059–14070 20. [IF=4.641] Fei Qu et al."Aggregation-induced emission of lead halide perovskites modulated by dispersed/aggregated gold nanoparticles for application in the detection of dopamine."Mater Res Bull. 2021 Oct;142:111405 21. [IF=4.35] Manli Wu et al.Simultaneous Determination of Purines and Uric Acid in Chinese Chicken Broth Using TFA/FA Hydrolysis Coupled with HPLC-VWD.Foods. 2021 Nov;10(11):2814 22. [IF=4.142] Zhang Wei et al."Ratiometric fluorescence and colorimetric dual-mode sensing platform based on carbon dots for detecting copper(II) ions and D-penicillamine."Anal Bioanal Chem. 2022 Feb;414(4):1651-1662 |
白色结晶或结晶性粉末。无气味,可溶于热的浓硫酸、甘油、碱溶液、乙酸钠和磷酸钠溶液。几乎不溶于水,不溶于乙醇和乙醚。加热至400℃以上分解出氢氰酸而不熔化,因此不能受强热。
取干燥鸡粪悬浮于24倍量水中,加入适量氢氧化钙后静置。沉淀完全后分出上清液,沉淀中再加水,用硝酸调节pH值至3,静置至沉淀完全。分出上清液,沉淀物再悬浮在水中,以氢氧化钙调节pH值至12~12.5,过滤后滤液以硝酸调pH值至3,析出物过滤、干燥后即为尿酸粗品。
可用于测定尿酸酶和钨酸盐的试剂。尿酸及其衍生物对皮肤无副作用,在化妆品中使用有多种调理功能。有显著保湿性能,能治疗皮肤功能失调,有抗氧化性,能延缓皮肤衰老和防止皮肤癌。在护发品中使用可抑制头屑。
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