2-(膦酰基甲基)戊二酸
2-PMPA(2-(Phosphonomethyl)pentanedioic acid)
CAS: 173039-10-6
化学式: C6H11O7P
| 中文名 | 2-PMPA |
| 英文名 | 2-(Phosphonomethyl)pentanedioic acid |
| 别名 | 化合物2-PMPA 2-PMPA游离态 2-(膦酰基甲基)戊二酸 NAALADASEINHIBITOR(易潮) |
| 英文别名 | 2-PMPA CS-2454 NAALADASEINHIBITOR PMPA(NAALADaseinhibitor) 2-PMPA(NAALADaseinhibitor) 2-(Phosphonomethyl)pentanedioic acid 2-(PHOSPHONOMETHYL)PENTANEDIOIC ACID Pentanedioic acid, 2-(phosphonomethyl)- 2-(Phosphonomethyl)pentane-1,5-dioicacid 2-(PHOSPHONOMETHYL)PENTANEDIOIC ACID (PMPA) |
| CAS | 173039-10-6 |
| 化学式 | C6H11O7P |
| 分子量 | 226.12 |
| 密度 | 1.658±0.06 g/cm3(Predicted) |
| 沸点 | 538.8±60.0 °C(Predicted) |
| 酸度系数 | 2.06±0.10(Predicted) |
| 存储条件 | room temp |
| 外观 | 粉末 |
| 颜色 | white to beige |
| 体外研究 | 2-PMPA is a potent and selective inhibitor of GCPII, an enzyme which catabolizes the abundant neuropeptide N-acetyl-aspartyl-glutamate (NAAG) to N-acetylaspartate (NAA) and glutamate. 2-PMPA demonstrates robust efficacy in numerous animal models of neurological disease. 2-PMPA is a highly polar compound with multiple negative charges causing significant challenges for analysis in biological matrices. 2-PMPA reduces ketamine-induced decrease of cell viability and increase of LDH levels in the mixed cultures but not in the neuronal cultures. |
| 体内研究 | Intraperitoneal administration of 100 mg/kg 2-PMPA results in maximum concentration in plasma of 275 μg/mL at 0.25 h. The half-life, area under the curve, apparent clearance, and volume of distribution are 0.64 h, 210 μg×h/mL, 7.93 mL/min/kg, and 0.44 L/kg, respectively. 2-PMPA at 250 mg/kg, in an anesthetized mouse, after an initial rise, produces a rapid decline and a striking attenuation in BOLD signals in gray matter. The signature of 2-PMPA on brain T 2 * signals in gray matter at both 167 and 250 mg/kg includes a significant initial rise lasting several minutes. 2-PMPA has neuroprotective activity in an animal model of stroke and anti-allodynic activity in CCI model. Administration of 2-PMPA (50mg/kg) produces a mean peak concentration of 2-PMPA of 29.66±8.1 μM. This concentration is about 100,000 fold more than is needed for inhibition of NAAG peptidase, and indicates very good penetration to the brain. Administration of 50 mg/kg 2-PMPA (i.p.) produces a continuously increasing extracellular NAAG concentration, which startes directly after application. |
| RTECS | SA0454800 |
2-(膦酰基甲基)戊二酸 - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 4.422 ml | 22.112 ml | 44.224 ml |
| 5 mM | 0.884 ml | 4.422 ml | 8.845 ml |
| 10 mM | 0.442 ml | 2.211 ml | 4.422 ml |
| 5 mM | 0.088 ml | 0.442 ml | 0.884 ml |
最后更新：2024-01-02 23:10:35
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产品名: 2-(膦酰基甲基)戊二酸 去供应商网站查看 询盘CAS: 173039-10-6
产地: 中国上海
包装: 5mg
规格: 98%
价格: 828.00
库存: 现货
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产品描述: 中文名：2-(膦酰基甲基)戊二酸 英文名:2-PMPA CAS:173039-10-6 规格:98% 产地:中国上海
现货供应
产品名: 2-(膦酰基甲基)戊二酸 去供应商网站查看 询盘CAS: 173039-10-6
产地: 中国上海
包装: 5mg
规格: 98%
价格: 828.00
库存: 现货
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013
微信: 18017137653
产品描述: 中文名：2-(膦酰基甲基)戊二酸 英文名:2-PMPA CAS:173039-10-6 规格:98% 产地:中国上海
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