中文名 | 2-甲基-2,6-壬二烯-1-胺 |
英文名 | N-(2,6-dimethylphenyl)-1-methylpiperidine-2-carboxamide |
别名 | 6-壬二烯-1-胺 2-甲基-2,6-壬二烯-1-胺 N-(26-二甲基苯基)-1-甲基哌啶-2-甲酰胺 |
英文别名 | Mepicaine Polocaine Carbocain Carbocaine DL-Mepivacaine 1-Methyl-2',6'-pipecoloxylidide 2',6'-Pipecoloxylidide, 1-methyl- (6CI, 8CI) N-(2,6-dimethylphenyl)-1-methylpiperidine-2-carboxamide 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl- (9CI) |
CAS | 96-88-8 |
EINECS | 202-543-0 |
化学式 | C15H22N2O |
分子量 | 246.35 |
密度 | 0.9978 (rough estimate) |
熔点 | 150-151° |
沸点 | 389.35°C (rough estimate) |
水溶性 | 2.217g/L(25 ºC) |
折射率 | 1.6280 (estimate) |
酸度系数 | 14.85±0.70(Predicted) |
存储条件 | Room Temprature |
体外研究 | Mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization. This leads to a blockage of nerve impulse initiation and conduction and results in a reversible loss of sensation. Compared to other local anesthetics, this agent has a more rapid onset and moderate duration of action. Mepivacaine has a reasonably rapid onset (more rapid than that of procaine) and medium duration of action (shorter than that of procaine). Mepivacaine displays a preferential use-dependent block of Na(v)1.8, S(-)-bupivacaine displays a preference for TTXs Na(+) channels. |
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