中文名 | 2-苯基喹啉-4-羧酸 |
英文名 | 2-Phenylcinchoninic Acid |
别名 | 阿托方 辛可芬 喹苯甲酸 苯基金鸡宁酸 2-苯基-4-喹啉羧酸 2-苯基喹啉-4-羧酸 2-苯基-4-喹啉甲酸 |
英文别名 | RHEUMIN RHEMATAN CINCHOPHEN LABOTEST-BB LT00453769 2-PHENYLCINCHONINIC ACID 2-Phenylcinchoninic Acid 2-PHENYLQUINOLINE-4-CARBOXYLIC ACID 2-PHENYL-4-QUINOLINECARBOXYLIC ACID 2-PHENYLQUINOLEINE-4-CARBOXYLIC ACID |
CAS | 132-60-5 |
EINECS | 205-067-1 |
化学式 | C16H11NO2 |
分子量 | 249.26 |
密度 | 1.1426 (rough estimate) |
熔点 | 214-215 °C (lit.) |
沸点 | 392.37°C (rough estimate) |
水溶性 | Insoluble in water |
溶解度 | 酒精: 溶于1克120毫升 (升) |
折射率 | 1.5300 (estimate) |
酸度系数 | 0.96±0.10(Predicted) |
存储条件 | Keep in dark place,Sealed in dry,Room Temperature |
敏感性 | Light Sensitive |
外观 | 固体 |
颜色 | White |
Merck | 14,2288 |
BRN | 192803 |
物化性质 | 白色或淡黄色结晶性粉末。粉点213-216℃。1g该品可溶于约400ml氯仿、100ml乙醚、120ml乙醇,几乎不溶于水。味微苦,几乎无臭。露置阳光下易起变化。 |
MDL号 | MFCD00006750 |
体外研究 | Cinchophen(2 - 苯基喹啉-4 - 羧酸)是一个功能强大的抗菌剂。 兽医将Cinchophen和泼尼松龙组合使用,治疗动物的关节炎。由于发现cinchophen会引起严重的肝损伤, 1930s停止了该药在人体的使用。 |
体内研究 | Cinchophen (oral gavage; 25-44 mg/kg; twice daily) combines prednisolone ( 0.125-0.220 mg/kg; twice daily) for 14 days is effective in dogs with osteoarthritis and well tolerated. The combination exhibits significantly improved lameness, weight bearing, joint mobility and stiffness scores and is similar in clinical efficacy to phenylbutazone.The kinetics and efficacy of a cinchophen prednisolone combination preparation (PLT) is tested. Cinchophen administation at a dose rate of 12.5 mg/kg intravenously exhibits a volume of distribution (V d area) of 0.13 L/kg, shows a clearance rate (Cl) of 0.15 L/h and a half-life (t 1/2β ) of 7.92 hours. The plasma concentration time curve (AUC0-∞) is 1187.0 μ/ml.h in dogs. Cinchophen administation (oral gavage; 12.5 mg/kg; single dose) exhibits a mean maximum plasma concentration (C max ) of 77.75 μg/ml and the time of Cmax (t max ) is 2.76 hours. The plasma concentration time curve (AUC 0-∞ ) is almost as large following oral as intravenous administration indicating an oral bioavailability (F) of 87.21%. |
危险品标志 | Xn - 有害物品 |
风险术语 | 22 - 吞食有害。 |
安全术语 | S36/37/39 - 穿戴适当的防护服、手套和护目镜或面具。 S26 - 不慎与眼睛接触后,请立即用大量清水冲洗并征求医生意见。 |
危险品运输编号 | 3249 |
WGK Germany | 3 |
RTECS | GD4025000 |
海关编号 | 29334990 |
Hazard Class | 6.1(b) |
Packing Group | III |
上游原料 | 甲酸钠 苯甲酰甲酸 |
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