20831-76-9
龙胆苦苷((5R-trans)-6-(β-D-glucopyranosyloxy)-5,6-dihydro-5-vinyl-1H,3H-pyrano[3,4-c]pyran-1-one)
CAS: 20831-76-9
化学式: C16H20O9
| 中文名 | 龙胆苦苷 |
| 英文名 | (5R-trans)-6-(β-D-glucopyranosyloxy)-5,6-dihydro-5-vinyl-1H,3H-pyrano[3,4-c]pyran-1-one |
| 别名 | 龙胆苦甙 龙胆苦苷 龙胆提取物.龙胆苦甙 龙胆苦苷(龙胆苦甙) 龙胆苦苷(分析标准品) 龙胆苦苷, 来源有龙胆根 GENTIOPICROSIDE 龙胆苦苷 |
| 英文别名 | 20831-76-9 GENTIOPICRIN gentiopicroside glucopyranosyloxy)-5,6-dihydro-,(5R-trans)- 1H,3H-Pyrano[3,4-c]pyran-1-one,5-ethenyl-6-(β-D- (5S,6R)-5-ethenyl-1-oxo-5,6-dihydro-1H,3H-pyrano[3,4-c]pyran-6-yl hexopyranoside (5R)-5β-Vinyl-6α-(β-D-glucopyranosyloxy)-5,6-dihydro-1H,3H-pyrano[3,4-c]pyran-1-one (5R,6S)-1-Oxo-5-vinyl-5,6-dihydro-1H,3H-pyrano[3,4-c]pyr-6-yl-beta-D-glucopyranoside (5R)-5β-Ethenyl-6α-(β-D-glucopyranosyloxy)-5,6-dihydro-1H,3H-pyrano[3,4-c]pyran-1-one (5R,6S)-1-Oxo-5-vinyl-5,6-dihydro-1H,3H-pyrano[3,4-c]pyran-6-yl beta-D-glucopyranoside (5R-trans)-6-(β-D-glucopyranosyloxy)-5,6-dihydro-5-vinyl-1H,3H-pyrano[3,4-c]pyran-1-one (5R,6S)-5-ethenyl-1-oxo-5,6-dihydro-1H,3H-pyrano[3,4-c]pyran-6-yl beta-D-glucopyranoside (5R-trans)-5-Ethenyl-6-(b-D-glucopyranosyloxy)-5,6-dihydro-1H,3H-pyrano[3,4-c]pyran-1-one 1H,3H-Pyrano[3,4-c]pyran-1-one, 5-ethenyl-6-(b-D-glucopyranosyloxy)-5,6-dihydro-, (5R,6S)- 1H,3H-pyrano[3,4-c]pyran-1-one, 5-ethenyl-6-(beta-D-glucopyranosyloxy)-5,6-dihydro-, (5R,6S)- 1H,3H-Pyrano[3,4-c]pyran-1-one, 5-ethenyl-6-(b-D-glucopyranosyloxy)-5,6-dihydro-, (5R-trans)- (5R-trans)-5-Ethenyl-6-(.beta.-d-glucopyranosyloxy)-5,6-dihydro-1H,3H-pyrano[3,4-c]pyran-1-one (5R,6S)-5-ethenyl-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5,6-dihydro-3H-pyrano[5,4-c]pyran-1-one (5R,6S)-6-{[(2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-5-vinyl-5,6-dihydro-1H,3H-pyrano[3,4-c]pyran-1-on (5R,6S)-6-{[(2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-5-vinyl-5,6-dihydro-1H,3H-pyrano[3,4-c]pyran-1-one (5R,6S)-5-éthènyl-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxyméthyl)tétrahydro-2H-pyran-2-yl]oxy}-5,6-dihydro-1H,3H-pyrano[3,4-c]pyran-1-one |
| CAS | 20831-76-9 |
| EINECS | 244-070-2 |
| 化学式 | C16H20O9 |
| 分子量 | 356.33 |
| InChI | InChI=1/C16H20O9/c1-2-7-8-3-4-22-14(21)9(8)6-23-15(7)25-16-13(20)12(19)11(18)10(5-17)24-16/h2-3,6-7,10-13,15-20H,1,4-5H2/t7-,10?,11?,12?,13?,15+,16?/m0/s1 |
| 密度 | 1.52±0.1 g/cm3(Predicted) |
| 熔点 | 191°C |
| 沸点 | 667.8±55.0 °C(Predicted) |
| 比旋光度 | -200 º (c=2, H2O) |
| 闪点 | 247.129°C |
| 蒸汽压 | 0mmHg at 25°C |
| 溶解度 | DMSO (微溶)，乙醇 (微溶，超声处理) |
| 折射率 | 1.623 |
| 酸度系数 | 12.79±0.70(Predicted) |
| 存储条件 | 2-8°C(protect from light) |
| 稳定性 | 吸湿性 |
| 敏感性 | Easily absorbing moisture |
| 外观 | 固体 |
| 颜色 | Pale Beige |
| 物化性质 | 类白色结晶粉末，易溶于甲醇，几乎不溶于乙醚，来源于长梗秦艽（西藏，甘肃）秦艽根茎 龙胆，苦胆草。 |
| MDL号 | MFCD00075700 |
| 体外研究 | Gentiopicroside inhibits P450 activity, with an IC 50 and a K i of 61 µM and 8.12 µM for CYP2A6, also slightly inhibits CYP2E1 activity with an IC 50 of 1.6 mM, but shows no inhibition on CYP1A2 and CYP3A4. Gentiopicroside (12.5, 25 and 50 μM) inhibits RANKL-induced osteoclast formation from mouse bone marrow macrophages (BMMs) in a dose-dependent manner, blocks the expression of osteoclast-related proteins, prevents receptor activator of nuclear factor-κB ligand (RANKL)-triggered JNK and NF-κB activation. Gentiopicroside (50 μM) also inhibits RANKL-induced bone resorption. |
| 体内研究 | Gentiopicroside (20, 40, and 80 mg/kg, p.o.) significantly reduces gastric ulcerindex in mice. Gentiopicroside (20, 40, and 80 mg/kg) also ovbiously decreases the levels of HSP-70, TNF-α, IL-6, MDA and increases ncreased GSH level and SOD activity. In addition, Gentiopicroside normalizes EGF and VEGF level in mice. |
| 海关编号 | 29389090 |
| 下游产品 | 2,3-二羟基苯甲酸甲酯 |
| 参考资料 展开查看 | 1. 杨倩, 赵伟刚, 王晓琴. 小秦艽花中总环烯醚萜和总酚酸的含量测定[J]. 安徽农业科学, 2019, 47(03):191-193. 2. 高艳,郝宝成,吴金措姆,格桑卓嘎,班旦,四郎玉珍,邢小勇,梁云,杨志伟,王兰芳,胡永浩,梁剑平,拉巴次旦.菪可轮蒲水煎液对多杀性巴氏杆菌体内外抑菌活性研究[J].动物医学进展,2019,40(07):43-48. 3. 韩多 赵志莲 刘卫红 李跃华 李海峰.三种龙胆属白族药用植物的品质评价及质量等同性[J].北方园艺 2016(18):165-170. 4. 杨文宁, 韩星, 杨海洋,等. 基于多成分药物代谢的秦艽质控成分遴选研究[J]. 世界中医药 2020年15卷13期, 1897-1902,1907页, ISTIC, 2020. 5. 吴昕怡 刘秀嶶 屈云慧 等. Box-Behnken设计-响应面法优化滇龙胆药材产地初加工工艺[J]. 中国药房 2020年31卷15期 1830-1835页 ISTIC PKU CA 2020. 6. 韩多 赵志莲 刘卫红 等. 3种龙胆属药用植物叶中主要有效成分的积累[J]. 中国医药工业杂志 2016 47(007):865-869. 7. 杨建华 朱丹丹 姜湘英 等. RP-HPLC法同时测定新疆假龙胆中5种活性成分含量[J]. 中药新药与临床药理 2015 v.26;No.135(06):116-119. 8. 王琳琳 尹海波 张紫嫣 等. 不同土壤施氮量与龙胆药材活性成分相关性分析[J]. 辽宁中医药大学学报 2017 019(005):72-75. 9. 韩多, 赵志莲, 刘卫红,等. 坚龙胆主要次生代谢产物及分子差异的研究[J]. 中国实验方剂学杂志, 2016, 022(018):35-39. 10. 何彩静, 王晶, 梁帅,等. 基于网络药理学探讨黄秦艽保肝作用机制[J]. 中国中药杂志, 2020, v.45(08):79-89. 11. 向雪滢, 杨建华, 胡君萍,等. 新疆假龙胆的保肝活性部位环烯醚萜苷提取纯化工艺研究[J]. 西北药学杂志, 2019, 34(02):151-158. 12. 韩多, 赵志莲, 刘卫红,等. 白族药用植物头花龙胆品质评价的初步探讨[J]. 中药材, 2016, 39(011):2549-2553. 13. 金琳, 李海峰, 刘卫红,等. 茉莉酸甲酯对滇龙胆叶中4种裂环烯醚萜类物质含量的影响[J]. 中国药房, 2019, 030(003):344-348. 14. 吴昕怡,刘秀嶶,屈云慧,石萍萍,杨雁,李智敏,田浩,谷丽萍.Box-Behnken设计-响应面法优化滇龙胆药材产地初加工工艺[J].中国药房,2020,31(15):1830-1835. 15. Tang W, Li W, Yang Y, Lin X, Wang L, Li C, Yang R. Phenolic Compounds Profile and Antioxidant Capacity of Pitahaya Fruit Peel from Two Red-Skinned Species (Hylocereus polyrhizus and Hylocereus undatus). Foods. 2021; 10(6):1183. https://doi.org/10.3390/food 16. [IF=4.06] Jianghua Yang et al."Hepatoprotective effects of Gentianella turkestanerum extracts on acute liver injury induced by carbon tetrachloride in mice."Am J Transl Res. 2017; 9(2): 569–579 17. [IF=0] Han Han et al."Exploration of Hepatoprotective Effect of Gentiopicroside on Alpha-Naphthylisothiocyanate-Induced Cholestatic Liver Injury in Rats by Comprehensive Proteomic and Metabolomic Signatures."Cell Physiol Biochem. 2018;49(4):1304-1319 18. [IF=0] Lifen Du et al."Potential Ameliorative Effects of Qing Ye Dan Against Cadmium Induced Prostatic Deficits via Regulating Nrf-2/HO-1 and TGF-β1/Smad Pathways."Cell Physiol Biochem. 2017;43(4):1359-1368 19. [IF=4.451] Cai-Jing He et al."Veratrilla baillonii Franch exerts anti-diabetic activity and improves liver injury through IRS/PI3K/AKT signaling pathways in type 2 diabetic db/db mice."J Funct Foods. 2020 Dec;75:104204 20. [IF=4.35] Wanpei Tang et al."Phenolic Compounds Profile and Antioxidant Capacity of Pitahaya Fruit Peel from Two Red-Skinned Species (Hylocereus polyrhizus and Hylocereus undatus)."Foods. 2021 Jun;10(6):1183 21. [IF=4.225] Huang Xian-ju et al."Veratrilla baillonii Franch Could Alleviate Lipid Accumulation in LO2 Cells by Regulating Oxidative, Inflammatory, and Lipid Metabolic Signaling Pathways."Front Pharmacol. 2020 Sep;0:1511 22. [IF=4.087] Yan Zhang et al."Gentiopicroside prevents alcoholic liver damage by improving mitochondrial dysfunction in the rat model."Phytother Res. 2021 Apr;35(4):2230-2251 23. [IF=3.935] Jie Li et al."Quality consistency evaluation between dispensing granules and traditional decoction of Gardeniae Fructus based on chemical similarity and bioequivalence."J Pharmaceut Biomed. 2022 May;213:114708 |
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产品名: Gentiopicroside 去供应商网站查看 询盘CAS: 20831-76-9
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产品描述: AN230281
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产品名: 龙胆苦苷(10mM in DMSO,无菌) 去供应商网站查看 询盘CAS: IG05101
产地: 北京
包装: 1ml/瓶
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现货供应
产品名: Gentiopicroside 去供应商网站查看 询盘CAS: 20831-76-9
产地: 中国-STD
包装: 支
规格: 10mg，25mg，50mg，100mg
价格: 电询
库存: 现货
电话: 0714-3999186
手机: 15671228036
电子邮件: 2853786052@qq.com
QQ: 2853786052
微信: 15671228036
产品描述: AN230281
提供多种规格现货供应
产品名: 龙胆苦苷(10mM in DMSO,无菌) 去供应商网站查看 询盘CAS: IG05101
产地: 北京
包装: 1ml/瓶
规格: IG05101-1ml
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 索莱宝直销,欢迎来询
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