21499-66-1
鸦胆子素D(Bruceine D)
CAS: 21499-66-1
化学式: C20H26O9
| 中文名 | 鸦胆子素D |
| 英文名 | Bruceine D |
| 别名 | 鸦胆因D 鸦胆子素D 鸦胆子素D(鸦胆子苦素D) (1R,2S,3R,3AR,3A1R,4R,6AR,7AS,11S,11AS,11BR)-1,2,3A,4,11-五羟基-3,8,11A-三甲基-2,3,3A, 4,7,7A,11,11A-八氢-1H-3,3A1-(EPOXYMETHANO)二苯并[DE,G]苯并吡喃-5,10(6AH,11BH)-二酮 |
| 英文别名 | BRUCEIND Nsc318801 Bruceine D Picras-3-ene-2,16-dione, 13,20-epoxy-1,11,12,14,15-pentahydroxy-, (1β,11β,12α,15β)- (1beta,11beta,12alpha,15beta)-13,20-Epoxy-1,11,12,14,15-pentahydroxypicras-3-ene-2,16-dione |
| CAS | 21499-66-1 |
| 化学式 | C20H26O9 |
| 分子量 | 410.42 |
| 密度 | 1.60 |
| 熔点 | 294-295℃ |
| 沸点 | 661.3±55.0 °C(Predicted) |
| 比旋光度 | -21 (Py) |
| 溶解度 | DMSO: 100毫克/毫升 (243.65毫米; 需要超声波) |
| 酸度系数 | 11.55±0.70(Predicted) |
| 存储条件 | 2-8°C |
| 外观 | 白色晶体或粉末 |
| 物化性质 | 白色结晶性粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于鸦胆子果实。 |
| MDL号 | MFCD00221753 |
| 参考资料 展开查看 | 1. 郑颖, 王刚阳, 陈瑞玲,等. 探讨鸦胆子素D对骨肉瘤细胞增殖,凋亡与自噬的作用[J]. 中国骨与关节杂志, 2017, 06(v.6):38-43. 2. 潘镏镏, 郑飞云, 诸海燕,等. 鸦胆子素D对HPV16感染细胞株的作用及其可能机制[J]. 温州医科大学学报, 2015(2):89-94. 3. Zhang, Yining, et al. "Development and validation of a sensitive LC–MS/MS assay for quantification of bruceine D in rat plasma." Biomedical Chromatography 30.11 (2016): 1873-1876.https://doi.org/10.1002/bmc.3724 4. Wang, Shangyu, et al. "Bruceine D inhibits tumor growth and stem cell‐like traits of osteosarcoma through inhibition of STAT3 signaling pathway." Cancer medicine 8.17 (2019): 7345-7358.https://doi.org/10.1002/cam4.2612 5. [IF=1.902] Yining Zhang et al."Development and validation of a sensitive LC–MS/MS assay for quantification of bruceine D in rat plasma."Biomed Chromatogr. 2016 Nov;30(11):1873-1876 6. [IF=3.357] Shangyu Wang et al."Bruceine D inhibits tumor growth and stem cell‐like traits of osteosarcoma through inhibition of STAT3 signaling pathway."Cancer Med-Us. 2019 Dec;8(17):7345-7358 |
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