中文名 | 2-(2,6-二氧代哌啶-3-基)-5-羟基-1H-苯并[de]异喹啉-1,3(2H)-二酮 |
英文名 | WUN29654 |
别名 | 化合物WUN29654 2-(2,6-二氧代哌啶-3-基)-5-羟基-1H-苯并[de]异喹啉-1,3(2H)-二酮 |
英文别名 | WUN29654 WUN-29654 CRBN modulator-1 2-(2,6-Dioxopiperidin-3-yl)-5-hydroxy-1H-benzo[de]isoquinoline-1,3(2H)-dione 1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-hydroxy- |
CAS | 2407829-65-4 |
化学式 | C17H12N2O5 |
分子量 | 324.29 |
溶解度 | 溶于DMSO |
存储条件 | -20℃ |
产品用途 | WUN29654 is a CRBN modulator, which showed CRBN modulatory activity with IC50 value of 2.6μM, Ki value of 0.7μM and cell proliferation IC50 vale of ~21.53μM. WUN29654 was reported in patent WO 2020006262 (compound II). WUN29654 has CAS#2407829-65-4, no formal name For the convenience of scientific communication, we named it as WUN29654 (combined from Inchi key plus CAS#) according to Hodoodo Chemical Nomenclature。 |
参考资料 展开查看 | Gray, Nathanael; Zhang, Tinghu; Fischer, Eric; Verano, Alyssa; He, Zhixiang; Du, Guangyan; Donovan, Katherine; Nowak, Radoslaw; Yuan, Christine. 2-(2,6-Dioxopiperidin-3-yl)benzo[de]isoquinoline-1,3(2H)-diones as CRBN modulators and their preparation. PCT Int. Appl. (2020), WO 2020006262. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.084 ml | 15.418 ml | 30.836 ml |
5 mM | 0.617 ml | 3.084 ml | 6.167 ml |
10 mM | 0.308 ml | 1.542 ml | 3.084 ml |
5 mM | 0.062 ml | 0.308 ml | 0.617 ml |
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