24735-18-0_化工百科

中文名	Leonurine hydrochloride
英文名	4-(diaminomethylideneamino)butyl 4-hydroxy-3,5-dimethoxybenzoate,hydrochloride
别名	益母草碱单盐酸盐盐酸益母草碱(益母草碱盐酸盐)
英文别名	SCM-198 HCl SCM-198 hydrochloride Leonurine hydrochloride Leonurin monohydrochloride 4-Guanidinobutyl 4-hydroxy-3,5-diMethoxybenzoate hydrochloride 4-(diaminomethylideneamino)butyl 4-hydroxy-3,5-dimethoxybenzoate,hydrochloride 4-Hydroxy-3,5-dimethoxybenzoic acid 4-[(aminoiminomethyl)amino]butyl ester monohydrochloride
CAS	24735-18-0
化学式	C14H22ClN3O5
分子量	347.79458
熔点	194℃
存储条件	Sealed in dry,Room Temperature
物化性质	白色结晶粉末，易溶于甲醇、水，来源于益母草Leonurus artemisia (Laur.) S. Y. Hu F。
MDL号	MFCD09953249
体外研究	Leonurine (0, 5, 10, 20, 40, 80 µM) causes diminution in lipid accumulation, cellular cholesterol content, including total cholesterol (TC), free cholesterol (FC) and cholesteryl ester (CE), and increase in apoA-I- or HDL-mediated cholesterol efflux after treatment for 24 h. Leonurine also significantly and dose-dependently increases the expressions of ABCA1 and ABCG1 at the mRNA and protein levels in human THP-1 macrophages, and such effect is involved in PPARγ. Leonurine hydrochloride (LH) shows protective effect on cell viability of HepG2 and HL-7702 cells incubated with palmitic acid (PA) of free fatty acid (FFA) for 24 h. Leonurine hydrochloride (125, 250, 500 μM) improves cellular lipid accumulation in HepG2 and HL-7702 cells via activating AMPK/SREBP1 pathway. Leonurine (5, 10, 20 µM) inhibits the expression of iNOS, COX-2, PGE2, NO, TNF-α, and IL-6 in IL-1β-induced human chondrocytes, suppresses ECM degradation in human OA chondrocytes, and blocks IL-1β-induced PI3K and Akt phosphorylation in a dose-dependent manner.
体内研究	Leonurine (10 mg/kg/d, p.o.) significantly increases the expressions of PPARγ, LXRα, ABCA1 and ABCG1, and decreases both TG and TC levels in serum of mice. Leonurine hydrochloride (50, 100, 200 mg/kg) improves intracellular lipid accumulation via activating AMPK/SREBP1 pathway, enhances biochemical parameters, reduces hepatic lipoperoxide and increases antioxidant levels in mice. Leonurine (20 mg/kg, p.o.) ameliorates osteoarthritis development in mouse DMM model.

24735-18-0 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	2.875 ml	14.376 ml	28.752 ml
5 mM	0.575 ml	2.875 ml	5.75 ml
10 mM	0.288 ml	1.438 ml	2.875 ml
5 mM	0.058 ml	0.288 ml	0.575 ml

最后更新：2024-01-02 23:10:35

上海麦克林生化科技股份有限公司

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产品名: 盐酸益母草碱去供应商网站查看询盘
CAS: 24735-18-0
产地: 上海
规格: L860691
价格: 10mg-50,50mg-90,1g-654,5g-2950,250mg-240,1ml-205
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北京索莱宝科技有限公司

现货供应

产品名: Leonurinehydrochloride盐酸益母草碱标准品去供应商网站查看询盘
CAS: 24735-18-0
产地: 北京
包装: 瓶
规格: SL8020-20mg,20mg,IL0350-D-1ml,10mM*1mlinDMSO,IL0350-5mg,5mg,IL0350-10mg,10mg,IL0350-20mg,20mg
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上海吉至生化科技有限公司

现货供应

产品名: 盐酸益母草碱去供应商网站查看询盘
CAS: 24735-18-0
产地: 中国上海
包装: 1g
规格: 99%
价格: 5378.00
库存: 现货
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产品描述: 中文名：盐酸益母草碱英文名:4-(diaminomethylideneamino)butyl 4-hydroxy-3,5-dimethoxybenzoate, 更多

上海源叶生物科技有限公司

产品名: Leonurine hydrochloride 去供应商网站查看询盘
CAS: 24735-18-0
产地: 上海
规格: 99%
价格: 5mg 600,10mg 800,25mg 1500,50mg 2350
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