中文名 | 紫草酸 |
英文名 | Lithospermic acid |
别名 | 紫草酸 紫精酸 紫草酸对照品, 紫草酸(标准品) LITHOSPERMIC ACID 紫草酸 LITHOSPERMIC ACID 紫草酸 标准品 (2S,3S)-4-((E)-3-((R)-1-羧基-2-(3,4-二羟基苯基)乙氧基)-3-氧代丙烷-1-烯-1-基)-2-(3,4-二羟基苯基)-7-羟基-2,3-二氢苯并呋喃-3-羧酸 |
英文别名 | Aids071478 Aids-071478 Clinopodic acid H lithospermic acid Lithospermic acid 4-(3-(1-Carboxy-2-(3,4-dihydroxyphenyl)ethoxy)-3-oxo-1-propenyl)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-7-hydroxy-3-benzofurancarboxylic acid 3-Benzofurancarboxylic acid, 4-(3-(1-carboxy-2-(3,4-dihydroxyphenyl)ethoxy)-3-oxo-1-propenyl)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-7-hydroxy- 4-{(E)-2-[1-Carboxy-2-(3,4-dihydroxy-phenyl)-ethoxycarbonyl]-vinyl}-2-(3,4-dihydroxy-phenyl)-7-hydroxy-2,3-dihydro-benzofuran-3-carboxylic acid 4-{(1E)-3-[(1R)-1-carboxy-2-(3,4-dihydroxyphenyl)ethoxy]-3-oxoprop-1-en-1-yl}-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydro-1-benzofuran-3-carboxylic acid (2S,3S)-4-((E)-3-((R)-1-Carboxy-2-(3,4-dihydroxyphenyl)ethoxy)-3-oxoprop-1-en-1-yl)-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydrobenzofuran-3-carboxylic acid (2S,3S)-4-[(E)-3-[(1R)-1-carboxy-2-(3,4-dihydroxyphenyl)ethoxy]-3-oxoprop-1-enyl]-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydro-1-benzofuran-3-carboxylic acid (2S,3S)-4-{(1E)-3-[(1R)-1-carboxy-2-(3,4-dihydroxyphenyl)ethoxy]-3-oxoprop-1-en-1-yl}-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydro-1-benzofuran-3-carboxylic acid 3-Benzofurancarboxylic acid, 4-[(1E)-3-[(1R)-1-carboxy-2-(3,4-dihydroxyphenyl)ethoxy]-3-oxo-1-propen-1-yl]-2-(3,4-dihydroxyphenyl)-2,3-dihydro-7-hydroxy-, (2S,3S)- |
CAS | 28831-65-4 |
化学式 | C27H22O12 |
分子量 | 538.46 |
InChI | InChI=1/C27H22O12/c28-15-5-1-12(9-18(15)31)10-20(26(34)35)38-21(33)8-4-13-2-7-17(30)25-22(13)23(27(36)37)24(39-25)14-3-6-16(29)19(32)11-14/h1-9,11,20,23-24,28-32H,10H2,(H,34,35)(H,36,37)/b8-4+/t20-,23+,24-/m1/s1 |
密度 | 1.642±0.06 g/cm3(Predicted) |
熔点 | 183-188 °C |
沸点 | 862.6±65.0 °C(Predicted) |
比旋光度 | +103.7°(C 0.063, EtOH) |
闪点 | 291.3°C |
蒸汽压 | 9.83E-32mmHg at 25°C |
溶解度 | 可溶于甲醇、乙醇等溶剂,不溶于石油醚。 |
折射率 | 1.745 |
酸度系数 | 2.77±0.10(Predicted) |
存储条件 | under inert gas (nitrogen or Argon) at 2-8°C |
外观 | 浅黄色粉末 |
物化性质 | 淡黄色结晶,可溶于甲醇、乙醇、DMSO等有机溶剂,来源于丹参,紫草科紫草Lithospermum erythrorhizon根茎。 |
MDL号 | MFCD15146876 |
参考资料 展开查看 | 1. 胡伟慧 韩东岐 江坤 等. RP-HPLC法同时测定甘西鼠尾草中12种成分的含量[J]. 药物分析杂志 2016 v.36(03):486-493. 2. 孙锦 林力 彭勍 等. 不同浓度乙醇提取丹参中12种成分比较研究[J]. 中国中医药信息杂志 2019(9). 3. 鲁兖 吴赛伟 许丹华.冠心宁注射液中酚酸类成分的质量分析[J].中国中药杂志 2015 40(09):1744-1746. 4. 程沛, 韩东岐, 胡伟慧,等. 高效液相色谱法同时测定丹参中10种水溶性和4种脂溶性成分的含量[J]. 药物分析杂志, 2015(06):991-996. 5. 崔伟亮 李慧芬 张学兰 等. UPLC-QE/MS法分析丹参酒炙前后5种质变化合物[J]. 中成药 2019 041(004):844-849. 6. 郑文华, 奚亚亚, 曲丛丛,等. 酒丹参标准汤剂的质量评价. 中国实验方剂学杂志. 7. 梁从莲 张永清 李佳 等. 不同株系丹参有效成分比较研究[J]. 山东科学 2018(4):31-38. 8. 尉广飞 刘谦 李佳 等. 丹参根部活性成分分布规律研究[J]. 山东科学 2015 28(05):7-13. 9. 尉广飞 李佳 刘谦 等. 丹参根部颜色及其与活性成分含量的相关性研究[J]. 山东农业科学 2015(08):59-62. 10. Wang, Jixia, et al. "Discovery of new targets of phenolic acids in danshen using a label-free cell phenotypic assay." RSC Advances 5.33 (2015): 25768-25776.https://doi.org/10.1039/C4RA16102E 11. Zhou, Jing, et al. "A strategy for rapid discovery of traceable chemical markers in herbal products using MZmine 2 data processing toolbox: A case of Jing Liqueur." Chinese Herbal Medicines (2021). 12. [IF=5.81] Zhang Jing et al."Chemical Analysis and Multi-Component Determination in Chinese Medicine Preparation Bupi Yishen Formula Using Ultra-High Performance Liquid Chromatography With Linear Ion Trap-Orbitrap Mass Spectrometry and Triple-Quadrupole Tandem Mass 13. [IF=3.645] Yang Wang et al."Identification of Salvia species using high-performance liquid chromatography combined with chemical pattern recognition analysis."J Sep Sci. 2018 Feb;41(3):609-617 14. [IF=3.049] Jixia Wang et al."Discovery of new targets of phenolic acids in danshen using a label-free cell phenotypic assay."Rsc Adv. 2015 Mar;5(33):25768-25776 15. [IF=5.455] Wang Qingjun et al."Fingerprint analysis of phenolic acid extract of Salvia miltiorrhiza by digital reference standard analyzer with one or two reference standards."Chin Med-Uk. 2021 Dec;16(1):1-16 16. [IF=4.759] Yi Zhang et al."Screening of inhibitors against histone demethylation jumonji domain-containing protein 3 by capillary electrophoresis."J Chromatogr A. 2020 Feb;1613:460625 17. [IF=3.845] Zhang Yu et al."Integrating Pharmacokinetics Study, Network Analysis, and Experimental Validation to Uncover the Mechanism of Qiliqiangxin Capsule Against Chronic Heart Failure."Front Pharmacol. 2019 Sep;0:1046 18. [IF=3.411] Liu Hongyan et al."Effect Study of Continuous Monoculture on the Quality of Salvia miltiorrhiza Bge Roots."Biomed Res Int. 2020;2020:4284385 19. [IF=3.935] Yaqing Guo et al."An integrated strategy for the systematic chemical characterization of Salvianolate lyophilized injection using four scan modes based on the ultra-high performance liquid chromatography-triple quadrupole-linear ion trap mass spectrometry. |
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