中文名 | SDMA (Symmetric dimethylarginine) |
英文名 | (2S)-2-amino-5-[(N,N'-dimethylcarbamimidoyl)amino]pentanoic acid |
别名 | 对称性二甲基精氨酸 N,N-二甲基精氨酸 对称N,N-二甲基精氨酸 对称N,N'-二甲基精氨酸溶液,100PPM (S)-2-氨基-5-((双(甲基氨基)亚甲基)氨基)戊酸 (2S)-2-氨基-5-[(N,N'-二甲基甲脒基)氨基]戊酸 NG,NG′-二甲基-L-精氨酸二(对羟基偶氮苯-P'-磺酸盐)盐 |
英文别名 | SDMA-d6 Symmetric dimethylarginine NG,NG'-Dimethy-L-arginine-d6 L-Arg(Me, Me)-OH (syMMetrical) L-Arg(Me, Me)-OH (asyMMetrical) SDMA (Symmetric dimethylarginine) N5-[Bis(methylamino)methylene]-L-ornithine-d6 N5-[(Dimethylamino)iminomethyl]-L-ornithine-d6 (2S)-2-amino-5-[(N,N'-dimethylcarbamimidoyl)amino]pentanoic acid |
CAS | 30344-00-4 |
化学式 | C8H18N4O2 |
分子量 | 202.25 |
密度 | 1.22±0.1 g/cm3(Predicted) |
沸点 | 353.5±52.0 °C(Predicted) |
酸度系数 | 2.48±0.24(Predicted) |
存储条件 | Keep in dark place,Inert atmosphere,Room temperature |
稳定性 | 非常吸湿 |
外观 | 橙色粉末。 |
体外研究 | SDMA is the structural isomer of the cardiovascular risk marker asymmetric dimethylarginine, as an endogenous marker of renal function. SDMA does not directly inhibit NOS but is a competitor of arginine transport. SDMA is primarily eliminated by renal excretion and is a promising endogenous marker of glomerular filtration rate. SDMA inhibits dose dependently the NO synthesis in intact endothelial cells, whereas it has no effect on protein expression of NOS. SDMA is involved in the inflammatory process of chronic kidney disease, activating NF-κB and resulting in enhanced expression of IL-6 and TNF-α. |
体内研究 | SDMA is highly stable in serum and plasma, and the assay demonstrates excellent analytical performance. In unaffected dogs, SDMA remains unchanged whereas in affected dogs, SDMA increases during disease progression, correlating strongly with an increase in sCr and decrease in GFR. Chronic SDMA infusion leads to a significant increase of SDMA levels in mice, but the GFR did not change at 4 weeks. No histological changes are observed, particularly no effect on fibrosis or endothelias nitric oxide synthase expression. There is neither an effect of SDMA on systolic blood pressure nor on ejection fraction. |
参考资料 展开查看 | 1. [IF=2.193] Yang Yang et al."Simultaneous Determination of 34 Amino Acids in Tumor Tissues from Colorectal Cancer Patients Based on the Targeted UHPLC-MS/MS Method."J Anal Methods Chem. 2020;2020:4641709 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 4.944 ml | 24.721 ml | 49.443 ml |
5 mM | 0.989 ml | 4.944 ml | 9.889 ml |
10 mM | 0.494 ml | 2.472 ml | 4.944 ml |
5 mM | 0.099 ml | 0.494 ml | 0.989 ml |
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