中文名 | C29 |
英文名 | TLR2-IN-C29 |
别名 | 化合物C29 3-((2-羟基-3-甲氧基亚苄基)氨基)-2-甲基苯甲酸 |
英文别名 | C29 C-29 C 29 R2-IN-C29 TLR2-IN-C29 TLR2-IN-C29 (C29 ) 3-((2-Hydroxy-3-methoxybenzylidene)amino)-2-methylbenzoic acid Benzoic acid, 3-[[(2-hydroxy-3-methoxyphenyl)methylene]amino]-2-methyl- |
CAS | 363600-92-4 |
化学式 | C16H15NO4 |
分子量 | 285.29 |
密度 | 1.21±0.1 g/cm3(Predicted) |
熔点 | >192°C (dec.) |
沸点 | 505.7±50.0 °C(Predicted) |
溶解度 | DMSO (微溶) 、甲醇 (微溶) |
酸度系数 | 4.01±0.10(Predicted) |
存储条件 | Inert atmosphere,Store in freezer, under -20°C |
稳定性 | 湿度敏感 |
外观 | 固体 |
颜色 | Dark Orange |
体外研究 | C29 (10 or 50 μΜ; 1 hour) blocks P3C- and P2C-induced IL-8 mRNA dose-dependently in HEK-TLR2 stable transfectants. C29 (50-200 μM; 1 hour) inhibits P3C- and P2C-induced IL-1β gene expression significantly at both 1 h and 4 h following stimulation in THP-1 cells. C29 (25 or 50 μΜ; 1 hour) reduces P3C-induced but not P2C-induced TNF-α mRNA and IL-12 p40 protein significantly in primary murine macrophages. C29 (50 μΜ; 1 hour) blocks TLR2 bacterial agonist-induced proinflammatory gene expression in HEK-TLR2 cells and murine macrophages. Western Blot Analysis Cell Line: THP-1 cells Concentration: 150 μM Incubation Time: 1 hours Result: Diminished the interaction between endogenous TLR2 and myeloid differentiation primary response gene 88 (MyD88) at 15 and 30 min poststimulation with P3C. Western Blot Analysis Cell Line: Murine peritoneal macrophages Concentration: 50 μM Incubation Time: 1 hours Result: Blocked robust MAPK activation at 30 min and reduced NF-κB activation from 5 to 30 min. Prevented P3C-induced degradation of IκBα at 15 and 30 min. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.505 ml | 17.526 ml | 35.051 ml |
5 mM | 0.701 ml | 3.505 ml | 7.01 ml |
10 mM | 0.351 ml | 1.753 ml | 3.505 ml |
5 mM | 0.07 ml | 0.351 ml | 0.701 ml |
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