中文名 | 人参皂苷CK |
英文名 | Compound K |
别名 | 化合物 K 人参皂苷CK S-人参皂苷C-K 人参皂苷CK对照品, 人参皂苷 K, 来源于人参 20(S)-人参皂苷 C-K COMPOUND K 人参皂苷CK 人参皂苷CK(20(S)-人参皂苷CK S-人参皂苷CK,人参皂苷C-K,人参皂苷K,20 人参皂苷CK(20(S)-人参皂苷CK,人参皂苷C-K,人参皂苷K,20(S)-人参皂苷C-K) |
英文别名 | IH-901 Compound K Ginsenoside CK GINSENOSIDE COMPOUND K(P) 20(S)-Protopanaxadiol 20-O-D-glucopyranoside (20S)-20-O-β-D-Glucopyranosylprotopanaxadiol 20-(β-D-Glucopyranosyloxy)dammar-24-ene-3β,12β-diol 20-(β-D-Glucopyranosyloxy)-5α-dammara-24-ene-3β,12β-diol (20S)-20-(β-D-Glucopyranosyloxy)dammara-24-ene-3β,12β-diol b-D-Glucopyranoside, (3b,12b)-3,12-dihydroxydaMMar-24-en-20-yl |
CAS | 39262-14-1 |
化学式 | C36H62O8 |
分子量 | 622.88 |
密度 | 1.19 |
熔点 | 181~183℃ |
沸点 | 723.1±60.0 °C(Predicted) |
比旋光度 | (c, 1 in MeOH)+39 |
溶解度 | 溶于DMSO,吡啶,不溶于石油醚、氯仿等有机溶剂。 |
酸度系数 | 12.94±0.70(Predicted) |
存储条件 | 2-8℃ |
外观 | 白色粉末 |
物化性质 | 白色结晶粉末,可溶于甲醇、乙醇、DMSO等有机溶剂,来源于人参根茎,绞股蓝。 |
MDL号 | MFCD07772261 |
体外研究 | Ginsenoside C-K, a bacterial metabolite of G-Rb1, exhibits anti-inflammatory effects mainly by reducing inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, and proinflammatory cytokines. Ginsenoside C-K suppresses the expression of proinflammatory cytokines by downregulating the activities of IRAK-1, MAPKs, IKK-α, and NF-κB in LPS-treated murine peritoneal macrophages. Ginsenoside C-K also suppresses the expression of iNOS and COX-2 by inhibiting NF-κB signaling in LPS-stimulated RAW264.7 cells. In zymosan-treated bone-marrow-derived macrophages (BMDMs) and RAW264.7 cells, Ginsenoside C-K inhibits inflammatory responses by negatively regulating the secretion of proinflammatory cytokines, the activation of MAPKs, and the generation of ROS. In addition, anti-inflammatory activity of Ginsenoside C-K has been observed in LPS-stimulated microglial cells. Ginsenoside C-K hinders inflammatory responses by controlling both the generation of ROS and the activities of MAPKs, NF-κB, and AP-1. Ginsenoside C-K, a major metabolite of ginsenosides in the gastrointestinal tract, inhibits NF-κB signaling in a PXR-dependent manner. Ginsenoside C-K is shown to promote recovery of dextran sulfate sodium (DSS) -induced colitis by suppressing NF-κB activation. Ginsenoside C-K significantly reduces TNF-α-induced upregulation of IL-1β and iNOS mRNA levels, and restores the mRNA levels of PXR and CYP3A4 in LS174T cells. Ginsenoside C-K, one of the intestinal metabolites of 20(S)-protopanaxadiol derivatives, exhibits an inhibition against the activity of CYP2C9 in human liver microsomes with an IC 50 value of 32.0±3.6 μM, a weak inhibition against the activity of CYP2A6 in human liver microsomes with an IC 50 value of 63.6±4.2 μM, and an even weaker inhibition against the activity of CYP2D6 in human liver microsomes with an IC 50 value of more than 100 μM. |
体内研究 | The weight of the collagen-induced arthritis (CIA) mice increases slowly and is significantly less than that of the normal DBA/1 mice beginning on d 3 after injection of the emulsion. Ginsenoside C-K (28, 56, and 112 mg/kg) mice recover their weight by d 32 after the emulsion injection. Ginsenoside C-K (56 and 112 mg/kg) and Methotrexate (MTX)-treated (2 mg/kg) mice show significantly increased body weight on d 50 as compared with CIA mice. Hind paw-swelling began on d 24 post-immunization. CIA mice are treated from d 28 to d 50. Arthritis scores are measured every 4 d beginning on d 24. Ginsenoside C-K (56 and 112 mg/kg) significantly reduces the arthritis scores of the mice on d 51. |
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