中文名 | BTB-1 |
英文名 | 4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE |
别名 | 化合物BTB1 KIF18A抑制剂(BTB-1) 4-氯-2-硝基-1-(苯基磺酰基)苯 |
英文别名 | BTB-1 LABOTEST-BB LT01147747 4-CHLORO-2-NITRODIPHENYL SULFONE 4-Chloro-2-nitrodiphenyl sulphone 1-Benzenesulfonyl-4-chloro-2-nitro-benzene 4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE 4-chloro-2-nitro-1-(phenylsulphonyl)benzene |
CAS | 86030-08-2 |
化学式 | C12H8ClNO4S |
分子量 | 297.71 |
熔点 | 115 °C |
溶解度 | 溶于DMSO (30 mg/ml) |
存储条件 | Sealed in dry,Room Temperature |
稳定性 | 从提供的购买之日起稳定2年。DMSO中的溶液可以在-20 °C下储存长达2个月。 |
外观 | 固体 |
颜色 | White to off-white |
体外研究 | BTB-1 blocks the motility of Kif18A in a reversible manner. BTB-1 inhibits Kif18A in an adenosine triphosphate (ATP)-competitive but microtubule-uncompetitive manner and slows down the progression of cells through mitosis. 100 μM BTB-1 does not significantly inhibit any of the other tested mitotic kinesins. BTB-1 competes with ATP for Kif18A binding only when the motor-protein is associated with its pseudosubstrate microtubules. HeLa cells treated with BTB-1 accumulate in mitosis in a dose-dependent manner. BTB-1 shows cell toxicity with an EC 50 values of 35.8 μM. HeLa cells treated with 50 μM BTB-1 reveals severe defects in spindle morphology and chromosome alignment. Treatment with high concentrations of BTB-1 does not result in elongated spindles. |
风险术语 | 36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
安全术语 | S26 - 不慎与眼睛接触后,请立即用大量清水冲洗并征求医生意见。 S36/37/39 - 穿戴适当的防护服、手套和护目镜或面具。 |
Hazard Class | IRRITANT |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.359 ml | 16.795 ml | 33.59 ml |
5 mM | 0.672 ml | 3.359 ml | 6.718 ml |
10 mM | 0.336 ml | 1.679 ml | 3.359 ml |
5 mM | 0.067 ml | 0.336 ml | 0.672 ml |
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