中文名 | 依索唑胺 |
英文名 | 6-ethoxy-2-benzothiazolesulfonamide |
别名 | 依索唑胺 乙氧苯噻唑胺 6-乙氧基-2-苯并噻唑磺酰胺 |
英文别名 | L-643786 PNU-4191 ETHOXZOLAMIDE 6-ETHOXYZOLAMIDE 6-ethoxy-2-benzothiazolesulfonamid 6-ETHOXY-2-BENZOTHIAZOLESULFONAMIDE 6-ethoxy-2-benzothiazolesulfonamide 2-Benzothiazolesulfonamide, 6-ethoxy- 6-Ethoxy-1,3-benzothiazole-2-sulfonamide |
CAS | 452-35-7 |
EINECS | 207-199-5 |
化学式 | C9H10N2O3S2 |
分子量 | 258.32 |
InChI | InChI=1/C9H10N2O3S2/c1-2-14-6-3-4-7-8(5-6)15-9(11-7)16(10,12)13/h3-5H,2H2,1H3,(H2,10,12,13) |
密度 | 1.4767 (rough estimate) |
熔点 | 190-193°C(lit.) |
沸点 | 464.9±37.0 °C(Predicted) |
闪点 | 235°C |
水溶性 | 10.33mg/L(25 ºC) |
蒸汽压 | 8.05E-09mmHg at 25°C |
溶解度 | DMSO (微溶),乙酸乙酯 (微溶) |
折射率 | 1.6800 (estimate) |
酸度系数 | pKa 8.12(H2O t=25.0) (Uncertain) |
存储条件 | Refrigerator |
外观 | 固体 |
颜色 | Off-White |
Merck | 13,3790 |
体外研究 | Ethoxzolamide (ETZ) treatment causes >90% inhibition of reporter GFP fluorescence in infected macrophages. Moreover, in a 9-day macrophage survival assay, Ethoxzolamide (ETZ) treatment significantly inhibits the ability of M. tuberculosis to grow intracellularly. |
体内研究 | It is discovered that the lipid-soluble ethoxzolamide is converted in vivo to a water-soluble metabolite, while retaining high activity againstt the enzyme. At the minimal dose for maximal effect (4 mg/kg i.v. at 45 min) the IOP lowering is 4.2 mmHg, the concentration in anterior uvea is 2.5 pmol/kg, and the fractional inhibition of the enzyme (i) is 0.9995. The effect declines rapidly, attributable to the very short half-life of drug in plasma, leading to depletion of free drug in the anterior uvea and other tissues. Ethoxzolamide (ETZ) strongly downregulates GFP reporter fluorescence in mouse lungs, with 3-fold inhibition of GFP signal compare to that in the mock-treating control. There is a significant reduction of bacterial survival in the lungs of ETZ-treating mice compare to the mock-treating control. |
危险品标志 | Xi - 刺激性物品 |
风险术语 | 36/37/38 - 刺激眼睛、呼吸系统和皮肤。 |
安全术语 | 26 - 不慎与眼睛接触后,请立即用大量清水冲洗并征求医生意见。 |
WGK Germany | 3 |
RTECS | DL6390000 |
上游原料 | 高锰酸钾 次氯酸钠 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.871 ml | 19.356 ml | 38.712 ml |
5 mM | 0.774 ml | 3.871 ml | 7.742 ml |
10 mM | 0.387 ml | 1.936 ml | 3.871 ml |
5 mM | 0.077 ml | 0.387 ml | 0.774 ml |
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