中文名 | 科罗索酸 |
英文名 | corosolic acid |
别名 | 科罗索酸 巴拉巴提取物 2Α-羟基熊果酸 科罗索酸(标准品) 巴拿巴提取物科罗索酸 2-alpha-羟基熊果酸 科罗索酸(2Α-羟基熊果酸) COROSOLIC ACID 科罗索酸 |
英文别名 | Corosolic Corsolicacid Corosolic acid corosolic acid COROSOLIC ACID HYDROXYURSOLIC ACID 2-A-HYDROXYURSOLIC ACID 2ALPHA-HYDROXYURSOLIC ACID 2,3-DIHYDROXYURS-12-EN-28-OIC ACID (2a,3b)-2,3-Dihydroxy-urs-12-en-28-oic acid (2alpha,3beta)-2,3-dihydroxyurs-12-en-28-oic acid (2alpha,3beta,5xi,18alpha)-2,3-dihydroxyurs-12-en-28-oic acid |
CAS | 4547-24-4 |
EINECS | 610-253-4 |
化学式 | C30H48O4 |
分子量 | 472.7 |
InChI | InChI=1/C30H48O4/c1-17-10-13-30(25(33)34)15-14-28(6)19(23(30)18(17)2)8-9-22-27(5)16-20(31)24(32)26(3,4)21(27)11-12-29(22,28)7/h8,17-18,20-24,31-32H,9-16H2,1-7H3,(H,33,34)/t17-,18+,20-,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1 |
密度 | 1.14±0.1 g/cm3(Predicted) |
熔点 | 243~245℃ |
沸点 | 573.3±50.0 °C(Predicted) |
比旋光度 | (c, 1 in Py)+42.1 |
闪点 | 314.6°C |
蒸汽压 | 1.56E-15mmHg at 25°C |
溶解度 | 甲醇: 可溶物1mg/mL,澄清,无色 |
折射率 | 1.566 |
酸度系数 | 4.67±0.70(Predicted) |
存储条件 | 2-8°C |
外观 | 整洁 |
颜色 | White |
物化性质 | 可溶于石油醚、苯、氯仿、吡啶等有机溶剂,不溶于水,可溶于热乙醇、甲醇。 来源于千屈菜科大花紫薇(Lagerstroemia speciosa (L.) Pers.) |
MDL号 | MFCD06794973 |
WGK Germany | 3 |
海关编号 | 2918195000 |
参考资料 展开查看 | 1. 邹盛勤 姜琼. RP-HPLC法同时测定线纹香茶菜不同生长部位中三萜酸成分[J]. 中成药 2015 37(3):570-573. 2. 符映均 胡浩彬. 一测多评法测定倍力舒合剂中4种三萜酸的含量[J]. 南京中医药大学学报 2015 000(003):277-279. 3. 霍宇航, 李檐堂, 刘丽丽,等. 基于主要功能成分的6 个品种枇杷叶分析评价[J]. 食品科学, 2019, 40(24). 4. Shi-Sheng Wang, Li-Juan Luo, Zhi-Gang Gao, Tong-Wei Guan, Wei-Jie Zhao, A convenient synthesis of 2β,3α-dihydroxyurs-12-en-28-oic acid as a natural diastereoisomer of corosolic acid, Chinese Chemical Letters, Volume 24, Issue 7, 2013, Pages 617-618, ISSN 1 5. [IF=6.779] Shi-Sheng Wang et al."A convenient synthesis of 2β,3α-dihydroxyurs-12-en-28-oic acid as a natural diastereoisomer of corosolic acid."Chinese Chem Lett. 2013 Jul;24:617 6. [IF=5.646] Ma Bo et al."Corosolic acid, a natural triterpenoid, induces ER stress-dependent apoptosis in human castration resistant prostate cancer cells via activation of IRE-1/JNK, PERK/CHOP and TRIB3."J Exp Clin Canc Res. 2018 Dec;37(1):1-16 7. [IF=3.935] Li Li et al."Rapid identification of urokinase plasminogen activator inhibitors from Traditional Chinese Medicines based on ultrafiltration, LC–MS and in silico docking."J Pharmaceut Biomed. 2019 Feb;164:241 8. [IF=3.935] Yong-Sheng Wu et al."Chemical profiling of Callicarpa nudiflora and its effective compounds identification by compound-target network analysis."J Pharmaceut Biomed. 2020 Apr;182:113110 9. [IF=3.638] Mengting Ni et al."Inhibitory effect of corosolic acid on α-glucosidase: kinetics, interaction mechanism, and molecular simulation."J Sci Food Agr. 2019 Oct;99(13):5881-5889 10. [IF=1.175] Wang Meng et al."Mechanism of molecules crosstalk and the critical role of jasmonic acid on triterpenoid synthesis in Cyclocarya Paliurus cells under Aspergillus niger elicitor."J Plant Biochem Biot. 2022 Jan;:1-16 |
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