中文名 | SULINDAC |
英文名 | SULINDAC SULFIDE |
别名 | 舒林酸硫醚 舒林酸EP杂质C 化合物 T13037 舒林酸USP相关化合物C 舒林酸相关化合物C(USP) |
英文别名 | SULINDAC SULINDAC SULFIDE Einecs 256-403-9 SULINDAC SULPHIDE (Z)-Sulindac sulfide (Z)-5-FLUORO-2-METHYL-1-[P-(METHYLTHIO)BENZYLIDENE]INDENE-3-ACETIC ACID (Z)-5-FLUORO-2-METHYL-1-(4-METHYLTHIOBENZYLIDENE)-1H-INDEN-3-YLACETIC ACID 5-Fluoro-2-methyl-1-[(Z)-[4-(methylthio)phenyl]methylene]-1H-indene-3-acetic acid (Z)-5-fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-1H-indene-3-acetic acid 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-((4-(methylthio)phenyl)methylene)-, (Z)- |
CAS | 49627-27-2 |
EINECS | 256-403-9 |
化学式 | C20H17FO2S |
分子量 | 340.41 |
熔点 | 189-191°C |
溶解度 | DMSO: >22 mg/mL |
存储条件 | -20°C Freezer |
外观 | 固体 |
颜色 | yellow |
体外研究 | Treatment with 100 μM of Sulindac sulfide (SSide) causes cell death presumably by inducing apoptosis, resulting in marked decrease in Aβgeneration as well as in total protein expression. The IC 50 value for Aβ42 secretion of Sulindac sulfide is 30.6±2.8 μM. SSone and naproxen have no effect either on Aβ40 or Aβ42 secretion as well as on Notch cleavage up to 100 μM. It is observed that an inhibition of γ 42 -secretase activity by Sulindac sulfide in a dose-dependent manner. The IC 50 value of SSide for inhibiting γ 42 -secretase activity in vitro is 20.2±2.6 μM. A decrease is found in slope by the increase of the concentration of SSide in the plot of rate against the enzyme concentration, suggesting that Sulindac sulfide is not an irreversible or pseudo-irreversible inhibitor. Moreover, when the dialyzed solubilizedγ-secretase fraction is pretreated with Sulindac sulfide against CHAPSO buffer without Sulindac sulfide, γ-secretase activity is almost totally recovered. From these data, it is strongly suggested that the genuine molecular target of Sulindac sulfide is the γ-secretase complex and that Sulindac sulfide works as a reversible γ-secretase inhibitor. |
危险品标志 | Xn - 有害物品 |
风险术语 | R22 - 吞食有害。 R42/43 - 吸入及皮肤接触可能致敏。 R63 - 可能有对胎儿造成伤害的危险。 |
WGK Germany | 3 |
海关编号 | 2930902000 |
微信搜索化工百科或扫描下方二维码,添加化工百科小程序,随时随地查信息!