中文名 | 5-羧基荧光素 |
英文名 | 5-carboxyfluorescein |
别名 | 5-羧基荧光素 5-羧基荧光素,5-FAM 5-羧基荧光素(单一化合物) 5-FAM [5-羧基荧光素] 5-CARBOXYFLUORESCEIN 5-羧基荧光素水合物 5-CARBOXYFLUORESCEIN 5-羧基荧光素 5-FAM 3',6'-二羟基-3-氧代-3H-螺[异苯并呋喃-1,9'-氧杂蒽]-5-羧酸 |
英文别名 | 5-FAM, 5-CF 5-CARBOXYLUORESCEIN 4-carboxyfluorescein 5-carboxyfluorescein Carboxyfluorescein,5- 5-Carboxyfluorescein (5-FAM) 5-Carboxyfluorescein Hydrate 4-(6-Hydroxy-3-oxo-3H-xanthen-9-yl)-isophth 3',6'-dihydroxy-3-keto-spiro[isobenzofuran-1,9'-xanthene]-5-carboxylic acid 3',6'-dihydroxy-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthene]-5-carboxylic acid 3',6'-Dihydroxy-3-oxo-spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-5-carboxylic Acid |
CAS | 76823-03-5 |
EINECS | 691-482-7 |
化学式 | C21H12O7 |
分子量 | 376.32 |
InChI | InChI=1/C21H12O7/c22-11-2-5-15-17(8-11)27-18-9-12(23)3-6-16(18)21(15)14-4-1-10(19(24)25)7-13(14)20(26)28-21/h1-9,22-23H,(H,24,25) |
InChIKey | NJYVEMPWNAYQQN-UHFFFAOYSA-N |
密度 | 1.73±0.1 g/cm3(Predicted) |
熔点 | 368-372°C |
沸点 | 725.2±60.0 °C(Predicted) |
闪点 | 266.9°C |
蒸汽压 | 4.5E-22mmHg at 25°C |
溶解度 | DMF: 可溶性 |
折射率 | 1.816 |
酸度系数 | 3.3, 4.6, 6.4, 7.0(at 25℃) |
存储条件 | Keep in dark place,Sealed in dry,2-8°C |
外观 | 固体 |
颜色 | Yellow to orange |
最大波长(λmax) | ['492nm'] |
BRN | 57037 |
MDL号 | MFCD00036874 |
体外研究 | 5-FAM contains a carboxylic acid that can be used to react with primary amines via carbodiimide activation of the carboxylic acid. Fluorescein is the most common fluorescent derivatization reagent for labeling biomolecules. In addition to its relatively high absorptivity, excellent fluorescence quantum yield, and good water solubility, fluorescein has an excitation maximum that closely matches the 488 nm spectral line of the argon-ion laser. |
危险品标志 | Xi - 刺激性物品 |
风险术语 | 36 - 刺激眼睛。 |
安全术语 | S26 - 不慎与眼睛接触后,请立即用大量清水冲洗并征求医生意见。 S39 - 戴护目镜或面具。 |
WGK Germany | 3 |
FLUKA BRAND F CODES | 8 |
海关编号 | 32129000 |
上游原料 | 5-羧基荧光素二乙酸酯 |
下游产品 | 6-羧基荧光素 |
参考资料 展开查看 | 1. [IF=7.727] Lina Guo et al."Rational design of metal-organic frameworks to deliver methotrexate for targeted rheumatoid arthritis therapy."J Control Release. 2021 Feb;330:119 2. [IF=2.589] Shenghui Zhong et al."Hyaluronic Acid-Coated MTX-PEI Nanoparticles for Targeted Rheumatoid Arthritis Therapy."Crystals. 2021 Apr;11(4):321 |
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