中文名 | 牛磺鹅去氧胆酸 |
英文名 | 2-{[(3alpha,5beta,7alpha,20xi)-3,7-dihydroxy-24-oxocholan-24-yl]amino}ethanesulfonic acid |
别名 | 牛磺鹅去氧胆酸 纯天然牛磺鹅去氧胆酸 牛磺鹅去氧胆酸标准品 |
英文别名 | C05465 2-[4-(3,7-dihydroxy-10,13- Taurochenodeoxycholic acid Taurocholic chenodeoxycholic acid 2-{[(3alpha,5beta,7alpha,20xi)-3,7-dihydroxy-24-oxocholan-24-yl]amino}ethanesulfonic acid 2-(4-(3,7-dihydroxy-10,13-diMethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanaMido)ethanesulfonic acid 2-((R)-4-((3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-Dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)ethanesulfonic acid 2-[4-(3,7-Dihydroxy-10,13-Dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-Tetradecahydro-1H-Cyclopenta[A]Phenanthren-17-Yl)Pentanoylamino]Ethanesulfonic Acid |
CAS | 516-35-8 |
化学式 | C26H45NO6S |
分子量 | 499.7 |
InChI | InChI=1/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16?,17-,18+,19+,20-,21-,22+,24-,25-,26+/m0/s1 |
密度 | 1.216±0.06 g/cm3(Predicted) |
熔点 | 186-200°C |
溶解度 | 氯仿,甲醇 |
折射率 | 1.552 |
酸度系数 | 1.42±0.50(Predicted) |
存储条件 | Sealed in dry,Room Temperature |
外观 | 固体 |
颜色 | White to Pale Beige |
物化性质 | 白色结晶体,可溶于甲醇、乙醇、DMSO等有机溶剂,来源于动物胆汁。 |
MDL号 | MFCD00232922 |
体外研究 | Taurochenodeoxycholic acid (12-Deoxycholyltaurine) dramatically improves the apoptosis rate of NR8383 cells in a concentration-dependent manner. In the meantime, Taurochenodeoxycholic acid significantly augments PKC mRNA levels, activities and increases JNK, caspase-3 and caspase-8 mRNA expression levels, activities. |
体内研究 | Taurochenodeoxycholic acid (12-Deoxycholyltaurine; 0.05, 0.1g/kg) decreases the pulmonary coefficient in the model mice and reduces the pathological damages on their lungs; it can decrease the expression levels of TNF-α and TIMP-2 in pulmonary tissues in the pulmonary fibrosis mice and has no significant effects on MMP2. Taurochenodeoxycholic acid significantly normalizes the clinical inflammatory parameters, prevented indomethacin-induced increases in the biliary contents of secondary bile acids and hydrophobicity index, and tended to attenuate the intestinal inflammation. Taurochenodeoxycholic acid significantly suppresses paw swelling and polyarthritis index, increases the loss body weight and index of thymus and spleen, and amends radiologic changes in AA rats. The overproduction and mRNA expression of TNF-α, IL-1β and IL-6 are remarkably suppressed in serum and synovium tissue of all TCDCA-treated rats. |
参考资料 展开查看 | 1. 李玮,蒋珍珍,李菡,屠鹏飞,宋青青,于娟,宋月林.利用在线加压溶剂提取-超高效液相色谱-离子阱-飞行时间-质谱法定性分析片仔癀化学成分组[J].色谱,2021,39(05):478-487. 2. [IF=3.935] Ziying Liu et al."Promotion of classic neutral bile acids synthesis pathway is responsible for cholesterol-lowing effect of Si-miao-yong-an decoction: Application of LC–MS/MS method to determine 6 major bile acids in rat liver and plasma."J Pharmaceut Bio 3. [IF=5.878] Min Wen et al."Geniposide suppresses liver injury in a mouse model of DDC-induced sclerosing cholangitis."Phytother Res. 2021 Jul;35(7):3799-3811 4. [IF=5.396] Shiming Huang et al."A sulfated polysaccharide from Gracilaria Lemaneiformis regulates cholesterol and bile acid metabolism in high-fat diet mice."Food Funct. 2019 Jun;10(6):3224-3236 5. [IF=5.34] Kaihui Zhang et al."A UPLC-MS/MS-based metabolomics analysis of the pharmacological mechanisms of rabdosia serra against cholestasis."Phytomedicine. 2021 Oct;91:153683 6. [IF=3.935] Runjing Zhang et al."Xiaoyan lidan formula ameliorates α-naphthylisothiocyanate-induced intrahepatic cholestatic liver injury in rats as revealed by non-targeted and targeted metabolomics."J Pharmaceut Biomed. 2020 Feb;179:112966 7. [IF=5.396] Juan Wu et al."Sargassum fusiforme polysaccharide is a potential auxiliary substance for metformin in the management of diabetes."Food Funct. 2022 Feb;: 8. [IF=6.558] Yan Cao et al."Widely quasi-quantitative analysis enables temporal bile acids-targeted metabolomics in rat after oral administration of ursodeoxycholic acid."ANALYTICA CHIMICA ACTA. 2022 Jun;1212:339885 |
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