52232-67-4
特立帕肽(Teriparatide)
CAS: 52232-67-4
化学式: C172H278N52O47S2
| 中文名 | 特立帕肽 |
| 英文名 | Teriparatide |
| 别名 | 特立帕肽 醋酸特立帕肽 醋酸立特帕肽 甲状旁腺素(人) 重组人甲状旁腺激素1-34 醋酸特立帕肽|PTH (1-34) (HUMAN) 醋酸特立帕肽 TERIPARATIDEACETATE |
| 英文别名 | Teriparatide TERIPARATIDE PTH (HUMAN, 1-34) PTH (1-34) (HUMAN) Teriparatide acetate PARATHYROID HORMONE (HUMAN, 1-34) PARATHYROID HORMONE (1-34), HUMAN SVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNF |
| CAS | 52232-67-4 |
| EINECS | 640-978-1 |
| 化学式 | C172H278N52O47S2 |
| 分子量 | 3890.49792 |
| InChI | InChI=1/C181H291N55O51S2/c1-21-96(18)146(236-160(267)114(48-53-141(250)251)212-174(281)132(84-239)232-177(284)143(93(12)13)233-147(254)103(185)82-237)178(285)216-111(45-50-134(187)241)155(262)219-119(65-90(6)7)163(270)213-116(55-62-289-20)158(265)224-124(71-100-79-196-86-203-100)167(274)226-126(73-135(188)242)169(276)217-117(63-88(2)3)148(255)201-81-138(245)205-105(39-27-30-56-182)149(256)223-123(70-99-78-195-85-202-99)166(273)221-121(67-92(10)11)164(271)225-128(75-137(190)244)171(278)231-131(83-238)173(280)214-115(54-61-288-19)157(264)210-112(46-51-139(246)247)153(260)208-109(43-34-60-199-181(193)194)159(266)234-144(94(14)15)175(282)215-113(47-52-140(248)249)156(263)222-122(69-98-77-200-104-38-26-25-37-102(98)104)165(272)220-120(66-91(8)9)161(268)209-108(42-33-59-198-180(191)192)151(258)206-106(40-28-31-57-183)150(257)207-107(41-29-32-58-184)152(259)218-118(64-89(4)5)162(269)211-110(44-49-133(186)240)154(261)228-129(76-142(252)253)172(279)235-145(95(16)17)176(283)229-125(72-101-80-197-87-204-101)168(275)227-127(74-136(189)243)170(277)230-130(179(286)287)68-97-35-23-22-24-36-97/h22-26,35-38,77-80,85-96,103,105-132,143-146,200,237-239H,21,27-34,39-76,81-84,182-185H2,1-20H3,(H2,186,240)(H2,187,241)(H2,188,242)(H2,189,243)(H2,190,244)(H,195,202)(H,196,203)(H,197,204)(H,201,255)(H,205,245)(H,206,258)(H,207,257)(H,208,260)(H,209,268)(H,210,264)(H,211,269)(H,212,281)(H,213,270)(H,214,280)(H,215,282)(H,216,285)(H,217,276)(H,218,259)(H,219,262)(H,220,272)(H,221,273)(H,222,263)(H,223,256)(H,224,265)(H,225,271)(H,226,274)(H,227,275)(H,228,261)(H,229,283)(H,230,277)(H,231,278)(H,232,284)(H,233,254)(H,234,266)(H,235,279)(H,236,267)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,286,287)(H4,191,192,198)(H4,193,194,199) |
| 熔点 | >205oC (dec.) |
| 溶解度 | DMSO (微溶) 、水 (微溶) |
| 存储条件 | −20°C |
| 外观 | 粉末 |
| 颜色 | White to Off-White |
| 体内研究 | Trabecular bone calcium and dry weight of the distal femur increased significantly in Teriparatide-treated animals. The increase in trabecular calcium compared with vehicle control occurred as early as 1 week after initiation of treatment with a 35% and 45% increase, respectively, for 10 μg/kg and 40 μg/kg Teriparatide. Similar results were observed for trabecular dry weight. After 4 weeks of treatment with 10 mg/kg or 40 mg/kg Teriparatide, trabecular calcium increased significantly by 70% and 123%, respectively, compared with the vehicle and by 73%. The 4-week Teriparatide administration increase the pore ratio, number, and density as well as the cortical area, thickness, and bone mineral content (BMC), without significant influencing the volumetric bone mineral density (BMD). The 4-week Teriparatide administration + 8-week vehicle administration decrease the pore ratio, number, and density as well as the cortical area and thickness, compared with the 4-week Teriparatide administration, but the pore ratio, cortical area, and thickness are still higher compared with the 12-week vehicle administration. The 4-week Teriparatide administration + 8-week higherdose IBN administration increase the cortical area, thickness, BMC, and volumetric BMD and decrease the pore ratio, but not the pore number or density, compared with the 4-week Teriparatide administration + 8-week vehicle administration. |
| WGK Germany | 3 |
| RTECS | SQ7770000 |
| 海关编号 | 2937190000 |
52232-67-4 - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 0.243 ml | 1.214 ml | 2.429 ml |
| 5 mM | 0.049 ml | 0.243 ml | 0.486 ml |
| 10 mM | 0.024 ml | 0.121 ml | 0.243 ml |
| 5 mM | 0.005 ml | 0.024 ml | 0.049 ml |
最后更新：2024-01-02 23:10:35
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产品名: Parathyroid Hormone Fragment (1-34) 去供应商网站查看 询盘CAS: 52232-67-4
产地: 上海
规格: 99%
价格: 1mg 500,5mg 980,10mg 1800,100mg 3500,500mg 10500
库存: 现货
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产品描述: Parathyroid Hormone Fragment (1-34) 99% MedMol 货号：S80776
现货供应
产品名: Parathyroid Hormone Fragment (1-34) 去供应商网站查看 询盘CAS: 52232-67-4
产地: 上海
规格: 99%
价格: 1mg 500,5mg 980,10mg 1800,100mg 3500,500mg 10500
库存: 现货
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403
微信: 18301782025
产品描述: Parathyroid Hormone Fragment (1-34) 99% MedMol 货号：S80776
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