56-75-7
氯霉素(chloroamphenicol)
CAS: 56-75-7
化学式: C11H12Cl2N2O5
| 中文名 | 氯霉素 |
| 英文名 | chloroamphenicol |
| 别名 | 氯霉素 氯霉素杂质 氯霉素(兽用) 氯霉素(药用级) 盐酸环丙沙星 杂质D D-苏-1-对硝基苯基-2-二氯乙酰氨基-1,3-丙二醇 D(-)-苏-1-对硝基苯基-2-二氯乙酰胺基-1,3-丙二醇 D-苏式-(-)-N-[alpha-(羟基甲基)-beta-羟基-对硝基苯乙基]-2,2-二氯乙酰胺 |
| 英文别名 | chloromycetin chloramphenicol chloroamphenicol ,[theta-(theta,theta)]- 2,2-dichloro-n-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-acetamid 2,2-dichloro-N-[(1S,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide 2,2-dichloro-n-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide 2,2-dichloro-n-(2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)-acetamid 2,2-dichloro-N-[(1R,2S)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide Acetamide, 2,2-dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl) 2,2-dichloro-N-[(1R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide [R-(R*,R*)]-2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]ethanamide d-(-)-threo-2,2-dichloro-n-[beta-hydroxy-alpha-(hydroxy-methyl)-p-nitrophenethyl]acetamide 2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-,[R-(R*,R*)]-Acetamide Acetamide, 2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-, [R-(R*,R*)]- Acetamide, 2,2-dichloro-N-[beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl]-, D-threo-(-)- |
| CAS | 56-75-7 |
| EINECS | 200-287-4 |
| 化学式 | C11H12Cl2N2O5 |
| 分子量 | 323.13 |
| InChI | InChI=1/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9?/m1/s1 |
| InChIKey | WIIZWVCIJKGZOK-RKDXNWHRSA-N |
| 密度 | 1.6682 (rough estimate) |
| 熔点 | 148-150°C(lit.) |
| 沸点 | 644.9±55.0 °C(Predicted) |
| 比旋光度 | 19.5 º (c=6, EtOH) |
| 闪点 | 14 °C |
| 水溶性 | 2.5 g/L (25 º C) |
| 蒸汽压 | 1.63E-17mmHg at 25°C |
| 溶解度 | 无水乙醇: soluble5-20mg/mL (作为储备溶液) |
| 折射率 | 20 ° (C=5, EtOH) |
| 酸度系数 | 11.03±0.46(Predicted) |
| 存储条件 | Keep in dark place,Inert atmosphere,2-8°C |
| 外观 | 粉末 |
| 颜色 | white |
| Merck | 14,2077 |
| BRN | 2225532 |
| 物化性质 | 白色或微黄带绿色针状结晶。熔点150.5-151.5℃(149.7-150.7℃)。在高真空下可以升华。微溶于水（2.5mg/ml，25℃），略溶于丙二醇（150.8mg/ml），易溶于甲醇、乙醇、丁醇、乙酸乙酯、丙酮，不溶于乙醚、苯、石油醚，植物油。味极苦。 |
| MDL号 | MFCD00078159 |
| 危险品标志 | T - 有毒物品 F - 易燃物品  |
| 风险术语 | R45 - 可能致癌。 R11 - 高度易燃。 R39/23/24/25 - R23/24/25 - 吸入、皮肤接触及吞食有毒。 |
| 安全术语 | S53 - 避免接触，使用前须获得特别指示说明。 S45 - 若发生事故或感不适，立即就医(可能的话，出示其标签)。 S16 - 远离火源。 S36/37 - 穿戴适当的防护服和手套。 |
| 危险品运输编号 | 2811 |
| WGK Germany | 3 |
| RTECS | AB6825000 |
| FLUKA BRAND F CODES | 3-10 |
| TSCA | Yes |
| 海关编号 | 29414000 |
| Hazard Class | 3 |
| 上游原料 | 4-硝基苯乙酮 苯甲醛 醋酸酐 二氯醋酸甲酯 甲苯 甲醛 硫酸 乌洛托品 溴素 氯苯 乙醇 S-氨基物 |
| 下游产品 | 氯霉素棕榈酸酯 |
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"Comparative pharmacokinetic analysis of extracts of crude and wine-processed Dipsacus asper in rats by a sensitive ultra performance liquid chromatography–tandem mass spectrometry approach." Journal of Chromatography B 1036 (2016): 33-41.h 14. Ming Lu, Chenyang Cao, Feng Wang, Guocong Liu,A polyethyleneimine reduced graphene oxide/gold nanocubes based electrochemical aptasensor for chloramphenicol detection using single-stranded DNA-binding protein,Materials & Design,Volume 199,2021,109409, 15. Cao, Weiyi, et al. "Simultaneous Quantification of Aspirin, Its Metabolite Salicylic Acid, and Salvianolic Acid B in Human Plasma Using UPLC-MS/MS." International Journal of Analytical Chemistry 2021 (2021). 16. Liu, Juan, et al. "Differential regulation and the underlying mechanisms of clay minerals to Escherichia coli under the stress of polymyxin B: Comparing halloysite with kaolinite." Chemosphere 265 (2021): 129095.https://doi.org/10.1016/j.chemosphere.2020.1 17. He, Baoshan, et al. "Aptamer-based thin film gold electrode modified with gold nanoparticles and carboxylated multi-walled carbon nanotubes for detecting oxytetracycline in chicken samples." Food chemistry 300 (2019): 125179.https://doi.org/10.1016/j.foodc 18. Li, Lei, et al. "A TIMS-TOF mass spectrometry study of disaccharides from in situ ESI derivatization with 3-pyridinylboronate." Analyst 146.1 (2021): 75-84.DOI: 10.1039/D0AN01677B 19. Ai-Yue Hao, Xue-Qing Wang, Yan-Zhen Mei, Jun-Fang Nie, Ya-Qiong Yang, Chuan-Chao Dai,A smartphone-combined ratiometric fluorescence probe for specifically and visibly detecting cephalexin,Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscop 20. [IF=4.379] Li Kai et al."Quantitative analysis, pharmacokinetics and metabolomics study for the comprehensive characterization of the salt-processing mechanism of Psoraleae Fructus."Sci Rep-Uk. 2019 Jan;9(1):1-10 21. [IF=2.896] Bao-Shan He et al."Electrochemical aptasensor based on aptamer-complimentary strand conjugate and thionine for sensitive detection of tetracycline with multi-walled carbon nanotubes and gold nanoparticles amplification."Anal Methods-Uk. 2018 Feb;10(7):783 22. [IF=7.991] Ming Lu et al."A polyethyleneimine reduced graphene oxide/gold nanocubes based electrochemical aptasensor for chloramphenicol detection using single-stranded DNA-binding protein."Mater Design. 2021 Feb;199:109409 23. [IF=7.514] Baoshan He et al."Aptamer-based thin film gold electrode modified with gold nanoparticles and carboxylated multi-walled carbon nanotubes for detecting oxytetracycline in chicken samples."Food Chem. 2019 Dec;300:125179 24. [IF=6.529] Weiyi Cao et al."Drug-drug interactions between salvianolate injection and aspirin based on their metabolic enzymes."Biomed Pharmacother. 2021 Mar;135:111203 25. [IF=6.057] Ruirui Xie et al."Lanthanide-functionalized metal-organic frameworks based ratiometric fluorescent sensor array for identification and determination of antibiotics."Talanta. 2021 Aug;231:122366 26. [IF=5.34] Kaihui Zhang et al."A UPLC-MS/MS-based metabolomics analysis of the pharmacological mechanisms of rabdosia serra against cholestasis."Phytomedicine. 2021 Oct;91:153683 27. [IF=5.316] Shang Gao et al."Electrochemical chloramphenicol sensors-based on trace MoS2 modified carbon nanomaterials: Insight into carbon supports."J Alloy Compd. 2021 Aug;872:159687 28. [IF=3.935] Runjing Zhang et al."Xiaoyan lidan formula ameliorates α-naphthylisothiocyanate-induced intrahepatic cholestatic liver injury in rats as revealed by non-targeted and targeted metabolomics."J Pharmaceut Biomed. 2020 Feb;179:112966 29. [IF=1.885] Cao Weiyi et al."Simultaneous Quantification of Aspirin, Its Metabolite Salicylic Acid, and Salvianolic Acid B in Human Plasma Using UPLC-MS/MS."Int J Anal Chem. 2021;2021:6620868 30. [IF=10.588] Yingying Zha et al."Size-dependent enhancement on conjugative transfer of antibiotic resistance genes by micro/nanoplastics."J Hazard Mater. 2022 Jun;431:128561 31. [IF=5.875] Yutong Wang et al."Extra virgin olive oil-based phospholipid complex/self-microemulsion enhances oral absorption of salvianolic acid B through inhibition of catechol-O-methyltransferase-mediated metabolism."Int J Pharmaceut. 2022 Jan;611:121330 32. [IF=2.896] Chunhui Lu et al."Rapid quantitative detection of chloramphenicol in three food products by lanthanide-labeled fluorescent-nanoparticle immunochromatographic strips."Analytical Methods. 2022 May;14(17):1705-1714 33. [IF=5.227] Shang Gao et al."The synergistic effects of MoS2 and reduced graphene oxide on sensing performances for electrochemical chloramphenicol sensor."FlatChem. 2022 May;33:100364 34. [IF=4.821] Weidao Yu et al."A turn-on fluorescent aptasensor for ampicillin detection based on gold nanoparticles and CdTe QDs."Microchem J. 2022 Aug;179:107454 35. [IF=0] Jian Gao et al."Comprehensive investigation on isolation, quantification, and activity evaluation of salvianolic acids for injection based on improved dry load injection technology."Separation Science Plus |
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