中文名 | 盐酸艾替伏辛 |
英文名 | Etifoxine Hydrochloride |
别名 | 盐酸艾替伏辛 盐酸依替福辛 艾替伏辛盐酸盐 |
英文别名 | StresaM Etifoxine Hydrochloride HOE-36801 hydrochloride Etifoxine·hydrochloride 2-EthylaMino-6-chloro-4-Methyl-4-phenyl-4H-3,1-benzoxazine Hydrochloride 6-Chloro-N-ethyl-4-Methyl-4-phenyl-4H-3,1-benzoxazin-2-aMine Hydrochloride 6-Chloro-2-(ethylamino)-4-methyl-4-phenyl-4H-3,1-benzoxazine hydrochloride 6-Chloro-2-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-aminehydrochloride 6-chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine monohydrochloride |
CAS | 56776-32-0 |
EINECS | 260-380-0 |
化学式 | C17H18Cl2N2O |
分子量 | 337.24362 |
熔点 | ND |
溶解度 | DMSO: ≥ 5 mg/mL |
存储条件 | -20°C |
外观 | 粉末 |
颜色 | white to beige |
体外研究 | Etifoxine (EFX), at concentrations ranging from 10 to 300 μM (higher concentrations limited its solubility), produces a dose-dependent increase in the [3H]muscimol binding at equilibrium, to 155±2% of its control value at 300 μM EFX. |
体内研究 | Etifoxine competitively inhibits [ 35 S]TBPS binding with micromolar potency in rat brain. Etifoxine (3.125-50 mg/kg) exhibits more pronounced anxiolytic and anticonvulsant effects in the BALB/cByJ mice compared to the C57BL/6J mice. Animal Model: Six-week old BALB/cByJ and C57BL/6J mice (20-25 g). Dosage: 3.125-50 mg/kg. Administration: Intraperitoneal inhection. Result: Significantly increased the amount of time spent on the open arms at the 12.5 mg/kg dose when compared to vehicle (p = 0.009) in BALB/cByJ mice but produced no effect in C57B/6J mice. BALB/cByJ mice compared with C57BL/6J mice exhibited significantly (p < 0.012) lower plasma levels of the compound at 15 and 30 min. |
危险品标志 | Xn - 有害物品 |
风险术语 | 22 - 吞食有害。 |
WGK Germany | 3 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.965 ml | 14.826 ml | 29.652 ml |
5 mM | 0.593 ml | 2.965 ml | 5.93 ml |
10 mM | 0.297 ml | 1.483 ml | 2.965 ml |
5 mM | 0.059 ml | 0.297 ml | 0.593 ml |
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