中文名 | 黄杞苷 |
英文名 | Engeletin |
别名 | 黄杞苷 黄杞苷对照品, 黄杞苷(标准品) 黄杞苷, 来源于黄杞 ENGELETIN 黄杞苷 二氢山柰酚-3-O-Α-L-鼠李糖苷 |
英文别名 | Engeletin Engelitin AroMadendrin 3-rhaMnoside Dihydrokaempferol 3-rhamnoside Dihydrokaempferol 3-O-alpha-L-rhamnopyranoside (+)-(2R,3R)-Dihydrokaempferol 3-O-alpha-L-rhamnoside (2R,3R)-5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-3-yl 6-deoxy-alpha-L-mannopyranoside (2R,3R)-5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(2S,3R,4R,5S,6S)-3,4,5-trihydroxy-6-methyl-oxan-2-yl]oxy-chroman-4-one 3-((6-Deoxy-alpha-L-Mannopyranosyl)oxy)-2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one(2R-trans) |
CAS | 572-31-6 |
EINECS | 300-009-2 |
化学式 | C21H22O10 |
分子量 | 434.39 |
密度 | 1.66 |
熔点 | 176-177℃ |
沸点 | 763.4±60.0 °C(Predicted) |
比旋光度 | (Me2CO)-16 |
溶解度 | 易溶于沸水,溶于DMSO、热甲醇,几乎不溶于乙醚。 |
酸度系数 | 7.37±0.60(Predicted) |
存储条件 | 2-8℃ |
外观 | 白色结晶 |
物化性质 | 类白色结晶性粉末,可溶于甲醇、乙醇、DMSO等有机溶剂,来源于土茯苓 Smilax glabra.菝葜。 |
MDL号 | MFCD01632717 |
体外研究 | Engeletin is a flavanonol glycoside isolated from hymenaea martiana , inhibits NF-κB signaling-pathway activation. |
体内研究 | Engeletin (25, 50, 100 mg/kg, i.p.) markedly reduces LPS-increased myeloperoxidase activity in mice, activates NF-κB-pathway activation, decreases the production of inflammatory mediators (iNOS and COX-2), and suppresses the expression of TLR4-signaling downstream molecules such as MyD88, IRAK1, TRAF6, and TAK1 proteins. |
海关编号 | 29389090 |
参考资料 展开查看 | 1. 刘丽娟,赵瑞芝,卢传坚.基于“药效-成分分析”的银屑灵优化方2号方抗银屑病配伍规律探讨[J].中华中医药杂志,2020,35(08):4171-4174. 2. 王梦雪,戴寒鹏,李金明,苏娅,韩欣然,李丽.土茯苓抑制CYP3A4酶活性的研究[J].长春师范大学学报,2020,39(08):60-63. 3. Guang Yang, Xin Zhao, Jun Wen, Tingting Zhou, Guorong Fan, Simultaneous fingerprint, quantitative analysis and anti-oxidative based screening of components in Rhizoma Smilacis Glabrae using liquid chromatography coupled with Charged Aerosol and Coulometric 4. [IF=4.192] Haichong Wu et al."Engeletin Alleviates Lipopolysaccharide-Induced Endometritis in Mice by Inhibiting TLR4-mediated NF-κB Activation."J Agr Food Chem. 2016;64(31):6171–6178 5. [IF=3.645] Weiquan Dai et al."Simultaneous chemical fingerprint and quantitative analysis of Rhizoma Smilacis Glabrae by accelerated solvent extraction and high-performance liquid chromatography with tandem mass spectrometry."J Sep Sci. 2015 May;38(9):1466-1475 6. [IF=4.098] Yangyang Fan et al."Interaction study of engeletin toward cytochrome P450 3A4 and 2D6 by multi-spectroscopy and molecular docking."Spectrochim Acta A. 2022 Jan;264:120311 |
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