中文名 | 异绿原酸 C |
英文名 | Isochlorogenic acid C |
别名 | 异绿原酸C 异绿原酸 C 异绿原酸C(4,5) 3,4-二咖啡酰奎尼酸 4,5-二咖啡酰奎宁酸 4,5-O-二咖啡酰奎宁酸 4,5-二-O-咖啡酰奎宁酸 4,5-二-O-咖啡酰奎宁酸(分析标准品) |
英文别名 | Isochlorogenic acid C 4,5-Dicaffeoylquinic acid Isochlorogenic acid C(4,5') 3,4-O-Dicaffeoylquinic acid 1β,5α-Dihydroxy-3β,4β-bis[3-(3,4-dihydroxyphenyl)propenoyloxy]cyclohexanecarboxylic acid (1R)-1,3β-Dihydroxy-4α,5α-bis[3-(3,4-dihydroxyphenyl)acryloyloxy]-1β-cyclohexanecarboxylic acid (1R,3R,4S,5R)-3,4-bis{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}-1,5-dihydroxycyclohexanecarboxylic acid (1R,3R,4S,5R)-1,5-Dihydroxy-3,4-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-1-cyclohexanecarboxylic acid |
CAS | 57378-72-0 32451-88-0 |
化学式 | C25H24O12 |
分子量 | 516.45 |
InChI | InChI=1/C25H24O12/c26-15-5-1-13(9-17(15)28)3-7-21(31)36-20-12-25(35,24(33)34)11-19(30)23(20)37-22(32)8-4-14-2-6-16(27)18(29)10-14/h1-10,19-20,23,26-30,35H,11-12H2,(H,33,34)/b7-3+,8-4+/t19-,20-,23+,25-/m1/s1 |
密度 | 1?+-.0.1 g/cm3(Predicted) |
沸点 | 810.8±65.0 °C(Predicted) |
闪点 | 274.9°C |
蒸汽压 | 8.9E-28mmHg at 25°C |
溶解度 | 可溶于水,易溶于热水、甲醇、乙醇、丙酮等亲水性溶剂,微溶于乙酸乙酯,难溶于乙醚、氯仿、苯等亲脂性有机溶剂。 |
折射率 | 1.719 |
酸度系数 | 3.70±0.50(Predicted) |
存储条件 | Inert atmosphere,Store in freezer, under -20°C |
外观 | 白色针晶粉末 |
物化性质 | 来源于金银花。 |
WGK Germany | 3 |
参考资料 展开查看 | 1. 迟森森 王卫华 刘斌.四妙勇安汤水提物大鼠吸收入血成分研究[J].北京中医药大学学报 2016 39(11):933-940. 2. 于潇, 迟森森, 焦其树,等. 基于在体肠灌流模型的四妙勇安汤活性成分拆方配伍研究[J]. 中国中药杂志, 2019, v.44(10):205-212. 3. 梁从莲, 刘红燕, 崔媛,等. 金银花指纹图谱及其清除DPPH自由基的谱-效关系[J]. 中国实验方剂学杂志, 2015. 4. 周游宇, 周莉莉, 乔勇,等. 山银花配方颗粒高效液相色谱特征指纹图谱研究[J]. 湖南中医杂志, 2019, v.35;No.243(05):153-155. 5. 马云, 王尧尧, 王蕾,等. 忍冬花发育期间形态与13种活性成分含量变化[J]. 中药材, 2018, 041(007):1559-1565. 6. 朱姮, 于金倩, 刘倩,等. 基于RRLC-DAD-ESI-Q-TOF-MS技术的山东金银花多指标定量指纹图谱分析[J]. 中国实验方剂学杂志, 2017, 023(019):82-89. 7. 刘倩 张敏敏 李圣波 等. HPLC-DAD法测定西藏产区金银花花蕾及叶中化学成分含量[J]. 山东科学 2018 031(004):20-25. 8. 孙婷婷 魏雅平 程红 等. HPLC法同时测定不同栽培区域滁菊中8种成分含量[J]. 安徽科技学院学报 2019 33(01):40-46. 9. 张莉 周娟娟. UPLC法同时测定银翘解毒合剂中10种成分[J]. 中成药 2018 40(08):86-89. 10. 李小军 张姝砣 穆云妹 等. "一测多评"法测定平卧菊三七中绿原酸类成分[J]. 中国医院药学杂志 2015(22):2007-2011. 11. 王俊俊 张俐 郭青 等. 一测多评法测定8个银翘解毒系列制剂中的7种酚酸类成分的含量[J]. 药学学报 2015 050(004):480-485. 12. 董婷, 周建良, 赵维良,等. 基于指纹图谱的银翘解毒颗粒质量评价[J]. 中国现代应用药学, 2018, 35(09):68-72. 13. 王玲娜, 刘红燕, 李佳,等. 忍冬叶有效成分含量与气候因子的灰色关联分析[J]. 山东农业科学, 2014(11):57-60. 14. 王春驰, 周婷婷, 纪圣君,等. 返魂草药材提取方法考察与特征图谱建立[J]. 长春中医药大学学报, 2019, 035(002):322-325. 15. 王玲娜,苏征,刘星劼,张芳,刘谦,张永清.金银花活性成分与生态因子相关性研究[J].中国实验方剂学杂志,2016,22(17):27-31. 16. 王玲娜 刘红燕 张金 等. "一测多评法"与外标法测定金银花中8种活性成分含量[J]. 中国实验方剂学杂志 2014 20(20):57-61. 17. 苏征 王玲娜 张芳 等. 不同产地忍冬藤HPLC指纹图谱比较研究[J]. 时珍国医国药 2017(05):193-195. 18. 路俊仙, 吕凌, 张才波. 忍冬4个药用部位中11种化学成分的含量测定[J]. 中药材, 2019(5). 19. 路俊仙, 吕凌, 张才波. 金银花和灰毡毛忍冬多成分定性的指纹图谱比较[J]. 中华中医药杂志, 2019, 034(007):3215-3219. 20. 王玲娜,张芳,李佳,刘红燕,姜秋,张永清.金银花新品种“华金6号”药材品质比较研究[J].中药材,2019,42(09):2030-2035. 21. 张敏敏, 刘代成, 王岱杰,等. SPME-GC/MS联合HSDE-HPLC-DAD分析表征金银花新品种中的主要化学成分[J]. 天然产物研究与开发, 2016, 028(009):1390-1396,1413. 22. 王玲娜, 孙希芳, 张芳,等. 不同发育时期金银花颜色与活性成分的相关性分析[J]. 中草药, 2017, 15(v.48;No.602):171-177. 23. 吴信华,李长印,曹园,瞿慧,韩洋,方祝元.基于LC/Q-TOF-MS整合网络药理学探讨潜阳育阴颗粒防治高血压肾损害的药效物质基础与作用机制[J].中国实验方剂学杂志,2021,27(02):116-129. 24. 胡飞凤,黄文康.高效液相色谱波长切换技术对复方野菊感冒颗粒中8种成分的含量测定[J].中国新药与临床杂志,2020,39(10):618-622. 25. 蔡芷辰,陈欢,杨蓉,陈佳佳,王程成,谈梦霞,陈佳丽,梅余琪,魏丽芳,殷圣鑫,刘训红.基于液相色谱-串联质谱结合多元统计分析盐胁迫下金银花代谢产物积累的变化[J].南京中医药大学学报,2020,36(05):584-592. 26. 李丽丽,李月,卢恒,王晓.基于液相色谱-质谱法的不同花期金银花代谢组学分析[J].分析测试学报,2020,39(12):1501-1507. 27. 徐林,宋健,冯玉,张会敏,王平.银翘散超微恒温浸提正交试验研究[J].时珍国医国药,2020,31(09):2127-2130. 28. 谭春梅,黄琴伟,王征南,马临科,赵维良.复方鱼腥草合剂特征图谱及基于Orbitrap超高分辨质谱结合多元数理统计方法的成分分析[J].药物分析杂志,2020,40(10):1770-1779. 29. 徐林,宋健,冯玉,张会敏.UPLC同时测定不同粒径银翘散中8种成分含量[J].山东中医药大学学报,2021,45(02):249-255. 30. Min Yang, Feng Zou, Qingxin Shi, Simin Ji, Xuanyuan Wang, Xingliang Xiang, Wan Li, Shuna Jin, Rongzeng Huang & Chengwu Song (2018) An efficient approach for enrichment of three isochlorogenic acids from Kuding tea using MCI-GEL resin, Journal of Liquid Chr 31. Xue, Gen, et al. "Integrating Study on Qualitative and Quantitative Characterization of the Major Constituents in Shuanghuanglian Injection with UHPLC/Q-Orbitrap-MS and UPLC-PDA." Journal of Analytical Methods in Chemistry 2021 (2021).https://doi.org/10.11 32. Li, Moying, et al. "Method for rapidly discovering active components in Yupingfeng granules by UPLC‐ESI‐Q‐TOF‐MS." Journal of Mass Spectrometry 55.10 (2020): e4627.https://doi.org/10.1002/jms.4627 33. Hengqiang Zhao, Changjiangsheng Lai, Minmin Zhang, Siduo Zhou, Qian Liu, Daijie Wang, Yanling Geng, Xiao Wang,An improved 2D-HPLC-UF-ESI-TOF/MS approach for enrichment and comprehensive characterization of minor neuraminidase inhibitors from Flos Lonicera 34. Hengqiang Zhao, Changjiangsheng Lai, Minmin Zhang, Siduo Zhou, Qian Liu, Daijie Wang, Yanling Geng, Xiao Wang,An improved 2D-HPLC-UF-ESI-TOF/MS approach for enrichment and comprehensive characterization of minor neuraminidase inhibitors from Flos Lonicera 35. Zhengqi Pan, Qinfen Wu, Zhe Xie, Qiang Wu, Xinti Tan, Xin Wang,Upregulation of HSP72 attenuates tendon adhesion by regulating fibroblast proliferation and collagen production via blockade of the STAT3 signaling pathway,Cellular Signalling,Volume 71,2020,10 36. [IF=4.411] Ai-Li Guo et al."Influence of Sulfur Fumigation on the Chemical Constituents and Antioxidant Activity of Buds of Lonicera japonica."Molecules. 2014 Oct;19(10):16640-16655 37. [IF=4.411] Ying Zhang et al."Compounds Identification in Semen Cuscutae by Ultra-High-Performance Liquid Chromatography (UPLCs) Coupled to Electrospray Ionization Mass Spectrometry."Molecules. 2018 May;23(5):1199 38. [IF=3.935] Liangmian Chen et al."Simultaneous determination of various bioactive redox components in Shuang–Huang–Lian preparations using a novel three-channel isocratic elution liquid chromatography with electrochemical detection system."J Pharmaceut Biomed. 2014 J 39. [IF=3.046] Menglin Wei et al."Protective effects of a Chotosan Fraction and its active components on β-amyloid-induced neurotoxicity."Neurosci Lett. 2016 Mar;617:143 40. [IF=2.081] Liangmian CHEN et al."Repeatability Assessment by ISO 11843-7 in Quantitative HPLC for Herbal Medicines."Anal Sci. 2015 Sep;31(9):903-909 41. [IF=1.645] Liangmian Chen et al."Quantitative Comparison of Caffeoylquinic Acids and Flavonoids in Chrysanthemum morifolium Flowers and Their Sulfur-Fumigated Products by Three-Channel Liquid Chromatography with Electrochemical Detection."Chem Pharm Bull. 2015 Jan;6 42. [IF=1.312] Min Yang et al."An efficient approach for enrichment of three isochlorogenic acids from Kuding tea using MCI-GEL resin."J Liq Chromatogr R T. 2018;41(4):188-195 43. [IF=8.198] Tong Wang et al."High-Speed Countercurrent Chromatography-Based Method for Simultaneous Recovery and Separation of Natural Products from Deep Eutectic Solvent Extracts."Acs Sustain Chem Eng. 2020;8(4):2073–2080 44. [IF=7.312] Qin Li et al."Efficient preparation of caffeoylquinic acids from the flowers of Artemisia anomala by supramolecular solvent/equilibrium solution extraction followed by re-extraction."Sep Purif Technol. 2021 Jun;265:118478 45. [IF=6.529] Rui Guo et al."Uncovering the pharmacological mechanisms of Xijiao Dihuang decoction combined with Yinqiao powder in treating influenza viral pneumonia by an integrative pharmacology strategy."Biomed Pharmacother. 2021 Sep;141:111676 46. [IF=5.81] Mu Jianfei et al."Determination of Polyphenols in Ilex kudingcha and Insect Tea (Leaves Altered by Animals) by Ultra-high-performance Liquid Chromatography-Triple Quadrupole Mass Spectrometry (UHPLC-QqQ-MS) and Comparison of Their Anti-Aging Effects."Fro 47. [IF=5.165] Huan Zhang et al."Fermentation characteristics and the dynamic trend of chemical components during fermentation of Massa Medicata Fermentata."Arab J Chem. 2022 Jan;15:103472 48. [IF=4.411] Shengxin Yin et al."Comparison of Multiple Bioactive Constituents in the Corolla and Other Parts of Abelmoschus manihot."Molecules. 2021 Jan;26(7):1864 49. [IF=4.411] Min Li et al."Study of the Variation of Phenolic Acid and Flavonoid Content from Fresh Artemisiae argyi Folium to Moxa Wool."Molecules. 2019 Jan;24(24):4603 50. [IF=4.35] Chengcheng Zhang et al."Chemical Characterization and Antioxidant Properties of Ethanolic Extract and Its Fractions from Sweet Potato (Ipomoea batatas L.) Leaves."Foods. 2020 Jan;9(1):15 51. [IF=3.935] Hengqiang Zhao et al."An improved 2D-HPLC-UF-ESI-TOF/MS approach for enrichment and comprehensive characterization of minor neuraminidase inhibitors from Flos Lonicerae Japonicae."J Pharmaceut Biomed. 2019 Oct;175:112758 52. [IF=3] Hui-Qin PAN et al."Plant metabolomics for studying the effect of two insecticides on comprehensive constituents of Lonicerae Japonicae Flos."Chin J Nat Medicines. 2021 Jan;19:70 53. [IF=2.633] Yanni Cao et al."Seasonal Variation in Phenolic Compounds and Antioxidant Activity in Leaves of Cyclocarya paliurus (Batal.) Iljinskaja."Forests. 2019 Aug;10(8):624 54. [IF=2.193] Xue Gen et al."Integrating Study on Qualitative and Quantitative Characterization of the Major Constituents in Shuanghuanglian Injection with UHPLC/Q-Orbitrap-MS and UPLC-PDA."J Anal Methods Chem. 2021;2021:9991363 55. [IF=1.902] Hongyan Liu et al."Spectrum–effect relationship study between HPLC fingerprints and antioxidant of honeysuckle extract."Biomed Chromatogr. 2019 Oct;33(10):e4583 56. [IF=1.813] Zhang Ying et al."Comparative Studies on Chemical Contents and Effect in Kidney-Yang Deficiency Rats of Salt-Processed Product and Wine-Processed Product of Cuscutae Semen."Evid-Based Compl Alt. 2019;2019:2049497 57. [IF=4.411] Yi Li et al."Evaluation of Anti-Inflammatory and Antioxidant Effectsof Chrysanthemum Stem and Leaf Extract on Zebrafish Inflammatory Bowel Disease Model."Molecules. 2022 Jan;27(7):2114 58. [IF=1.312] Xiaoran Zhao et al."Discrimination of Cuscuta chinensis Lam. and Cuscuta japonica Choisy based on a combination of chemometrics and fingerprint classification."Journal Of Liquid Chromatography & Related Technologies. 2022 Jan 09 59. [IF=4.36] Zhiyong Zhang et al."On-line screening of natural antioxidants and the antioxidant activity prediction for the extracts from flowers of Chrysanthemum morifolium ramat."JOURNAL OF ETHNOPHARMACOLOGY. 2022 Aug;294:115336 60. [IF=3.645] Lewen Xiong et al."Study on phenolic acids of Lonicerae japonicae Flos based on ultrahigh performance liquid chromatography-tandem mass spectrometry combined with multivariate statistical analysis."JOURNAL OF SEPARATION SCIENCE |
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