592542-60-4_化工百科

中文名	Rigosertib (sodium)
英文名	Rigosertib (sodium)
别名	瑞格色替钠化合物RIGOSERTIB PLK1抑制剂(RIGOSERTIB SODIUM)
英文别名	Novonex ON 01910 Na ON 01910 sodium RIGOSERTIB SODIUM Rigosertib (sodium) RIGOSERTIB SODIUM (ON-01910 SODIUM) (E)-2,4,6-Trimethoxystyryl 3-[(carboxymethyl)amino]-4-methoxybenzyl sulfone sodium salt Glycine, N-[2-Methoxy-5-[[[(1E)-2-(2,4,6-triMethoxyphenyl)ethenyl]sulfonyl]Methyl]phenyl]-, sodiuM Slat
CAS	592542-60-4
化学式	C21H24NNaO8S
分子量	473.47193
熔点	174-178℃
溶解度	溶于DMSO
存储条件	-20℃
产品用途	Rigosertib sodium (ON-01910 sodium) is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition the PI3K/Akt pathway, promotes the phosphorylation of histone H2AX and induces G2/M arrest in cell cycle. Rigosertib sodium is a selective and non-ATP-competitive inhibitor of PLK1 with an IC50 of 9 nM.
参考资料展开查看	1. Xu F, et al. Rigosertib as a selective anti-tumor agent can ameliorate multiple dysregulated signalingtransduction pathways in high-grade myelodysplastic syndrome. Sci Rep. 2014 Dec 4;4:7310.2. Hyoda T, et al. Rigosertib induces cell death of a myelodysplastic syndrome-derived cell line by DNA damage-induced G2/M arrest. Cancer Sci. 2015 Mar;106(3):287-93.3. Gumireddy K, et al. ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent. Cancer Cell. 2005 Mar;7(3):275-86.4. Reddy MV, et al. Discovery of a clinical stage multi-kinase inhibitor sodium (E)-2-{2-methoxy-5-[(2',4',6'-trimethoxystyrylsulfonyl)methyl]phenylamino}acetate (ON 01910.Na): synthesis, structure-activity relationship, and biological activity. J Med Chem.

592542-60-4 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	2.112 ml	10.56 ml	21.121 ml
5 mM	0.422 ml	2.112 ml	4.224 ml
10 mM	0.211 ml	1.056 ml	2.112 ml
5 mM	0.042 ml	0.211 ml	0.422 ml

最后更新：2024-01-02 23:10:35

592542-60-4 - 细胞实验

Cells are grown in either DMEM or RPMI supplemented with 10% fetal bovine serum and 1 unit/mL penicillin-streptomycin solution. Tumor cells are plated into six-well dishes at a density of 1 × 105cells/mL/well, and Rigosertib is added 24 hours later at various concentrations. Cell counts are determined from duplicate wells after 96-hour of treatment. The total number of viable cells is determined by trypan blue exclusio(Only for Reference)

最后更新：2023-08-16 21:32:38

592542-60-4 - 动物实验

Bel-7402 tumor models: twenty female athymic (NCR-nu/nu) nude mice are injected with 1 × 107 Bel-7402 tumor cells subcutaneously, and 10-14 days later, when the tumor volumes reach 200-250 mm, the mice are divided into four groups such that each group harbors tumors of the same volume. Rigosertib (ON01910, 250 mg/kg) dissolved in PBS is administered alone or in combination with NSC 266046 (100 mg/kg) intraperitonially on alternate days. Tumor measurements are done two times/week using traceable digital vernier calipers. Body weight is determined during each measurement. The animals are observed for signs of toxicity.

最后更新：2023-08-16 21:32:38

上海吉至生化科技有限公司

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产品名: Rigosertib (sodium) 去供应商网站查看询盘
CAS: 592542-60-4
产地: 中国上海
包装: 5mg
规格: 99%
价格: 1462.00
库存: 5个工作日
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产品描述: 中文名：Rigosertib (sodium) 英文名:Rigosertib (sodium) CAS:592542-60-4 规格:99% 产地:中国上海

上海麦克林生化科技股份有限公司

现货供应

产品名: Rigosertib sodium 去供应商网站查看询盘
CAS: 592542-60-4
产地: 上海
规格: R878299
价格: 10mg-1351,5mg-810
库存: 7天内发货
电话: 13816333479/17821173903
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上海源叶生物科技有限公司

产品名: Rigosertib (sodium) 去供应商网站查看询盘
CAS: 592542-60-4
产地: 上海
规格: 99%
价格: 5mg 650,10mg 1000,25mg 2000,100mg 6000
电话: 18301782025
手机: 18301782025
电子邮件: 3008007403@qq.com
QQ: 3008007403

微信: 18301782025
产品描述: Rigosertib (sodium) 99% MedMol 货号：S85894

上海吉至生化科技有限公司

现货供应

微信: 18017137653
产品描述: 中文名：Rigosertib (sodium) 英文名:Rigosertib (sodium) CAS:592542-60-4 规格:99% 产地:中国上海

上海麦克林生化科技股份有限公司

现货供应

微信: 19863730987/17821173903

上海源叶生物科技有限公司

微信: 18301782025
产品描述: Rigosertib (sodium) 99% MedMol 货号：S85894

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592542-60-4

Rigosertib (sodium)(Rigosertib (sodium))

CAS: 592542-60-4

化学式: C21H24NNaO8S

592542-60-4 - 配置溶液浓度参考

592542-60-4 - 细胞实验

592542-60-4 - 动物实验

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592542-60-4 询问

Rigosertib (sodium)(Rigosertib (sodium))

CAS: 592542-60-4

化学式: C21H24NNaO8S

592542-60-4 - 配置溶液浓度参考

592542-60-4 - 细胞实验

592542-60-4 - 动物实验

供应商列表

592542-60-4