中文名 | 盐酸药根碱 |
英文名 | 2,9,10-trimethoxy-5,13a-dihydro-6H-isoquino[3,2-a]isoquinolin-3-ol |
别名 | 盐酸药根碱 氯化药根碱 酸盐药根碱 药根碱盐酸盐 盐酸药根碱(标准品) 盐酸药根碱(药根碱盐酸盐) 盐酸药根碱, 来源于十大功劳 3-羟基-2,9,10-三甲氧基-5,6-二氢异喹啉[3,2-A]异喹啉-7-氯化铵 |
英文别名 | Nsc150445 Neprotine chloride Jatrorrhizine Hcl(Rg) Yatrorhizine chloride Jatrochizine chloride JATRORRHIZINE HCL(RG) Jatorrhizine, chloride Jatrorrhizine hydrochloride 2,9,10-trimethoxy-5,13a-dihydro-6H-isoquino[3,2-a]isoquinolin-3-ol |
CAS | 6681-15-8 1168-00-9 |
化学式 | C20H20NO4.ClH |
分子量 | 374.842 |
InChI | InChI=1/C20H19NO4.ClH/c1-23-18-5-4-12-8-16-14-10-19(24-2)17(22)9-13(14)6-7-21(16)11-15(12)20(18)25-3;/h4-5,8-11H,6-7H2,1-3H3;1H/p+1 |
熔点 | 208-210 °C(Solv: methanol (67-56-1)) |
溶解度 | 易溶于甲醇 |
存储条件 | Inert atmosphere,Room Temperature |
外观 | 橘红色粉状 |
体外研究 | Jatrorrhizine has antiplasmodial and antiamoebic activity, it against Plasmodium falciparum and E. histolytica with IC 50 values of 3.15 and 82.7 µM, respectively.The hOCT2 (organic cation transporter 2), hOCT3, and PMAT (plasma membrane monoamine transporter) are capable of transporting monoamine neurotransmitters in the brain. Jatrorrhizine has the inhibitory potency of jatrorrhizine on 5-HT and NE uptake in hOCT2-, hOCT3-, and PMAT-transfected cells. Jatrorrhizine strongly inhibits PMAT-mediated MPP + uptake with an IC 50 value of 1.05 μM and reduces 5-HT and NE uptake mediated by hOCT2, hOCT3, and hPMAT with IC 50 values of 0.1-1 μM (for OCT2 and OCT3) and 1-10 μM (for PMAT).Clearance of neurotransmitters released into the synaptic cleft is defined by two distinct processes. Uptake-1, the common target of current applied antidepressants, is comprised of the serotonin transporter (SERT), the “SERT”, had a high affinity but low capacity to take up [3H]5-HT. Uptake-2 transporters are an important supplementary regulation system in monoamine clearancethought to be the “NET”, has low affinity but high capacity to take up [ 3 H]5-HT into brain slices. Jatrorrhizine significantly inhibited 5-HT and NE uptake in synaptosomes at 25 μM and 50 μM. |
海关编号 | 29399990 |
参考资料 展开查看 | 1. 邹静 李琳 任青玲 等. 加味二妙颗粒剂与传统汤剂指纹图谱及指标成分含量的比较[J]. 中国实验方剂学杂志 2018(12). 2. 陈阳, 崔波, 范燕豪,等. 葛根芩连汤中各成分在正常与大肠湿热证模型大鼠的肠吸收差异研究[J]. 中国中药杂志, 2020, v.45(01):177-186. 3. 陈雪剑 杨梦玲 刘蔚 等. 加味小柴胡汤抗胃溃疡有效物质部位的血清药物化学研究[J]. 中国中药杂志 2018(8):1692-1700. 4. 闫琦 李莉 刁娟娟 等. HPLC法同时测定黑果小檗根中7种成分的含量[J]. 中药材 2019年42卷7期 1584-1588页 MEDLINE ISTIC PKU 2020. 5. 刘洋, 尹秀文, 王子禹,等. 黄连提取物的中药生物药剂学分类系统研究[J]. 中国中药杂志, 2017, 21(v.42):87-94. 6. 李淑娇 王宇卿. HPLC-ABTS-DAD-Q-TOF/MS在线筛选黄连抗氧化活性物质[J]. 中国中药杂志 2018(12). 7. 张纯刚, 唐静雅, 于琛琛,等. 黄连五种主要生物碱的提取纯化及含量测定[J]. 中国现代中药, 2018, 20(09):116-119+126. 8. 张潇, 张亚丽, 苗祥贞,等. 黄连不同炮制品及组分的抗肿瘤活性与6种生物碱含量相关性研究[J]. 中华中医药杂志, 2019, v.34(06):350-353. 9. 邹静 陈慧 彭懿 等. HPLC法同时测定加味二妙颗粒中7种成分及指纹图谱建立[J]. 中成药 2018 v.40(02):99-104. 10. 邱辉辉,韩瑞婷,盛丽莉,李后开.四妙方颗粒剂与汤剂防治非酒精性脂肪性肝病的对比研究[J].中草药,2021,52(04):1031-1038. 11. 康念欣,袁炎炎,张潇,路颖慧,李晴霞,李飞,谭鹏.酒黄连HPLC特征图谱的建立及聚类分析和主成分分析[J].世界科学技术-中医药现代化,2020,22(08):2790-2798. 12. Lvhuan Wang, Yumei Zhao, Yanyan Zhang, Tingting Zhang, Jeroen Kool, Govert W. Somsen, Qiqin Wang, Zhengjin Jiang, Online screening of acetylcholinesterase inhibitors in natural products using monolith-based immobilized capillary enzyme reactors combined wi 13. [IF=4.759] Lvhuan Wang et al."Online screening of acetylcholinesterase inhibitors in natural products using monolith-based immobilized capillary enzyme reactors combined with liquid chromatography-mass spectrometry."J Chromatogr A. 2018 Aug;1563:135 14. [IF=3.046] Liwei Dong et al."Echinacoside induces apoptotic cancer cell death by inhibiting the nucleotide pool sanitizing enzyme MTH1."Oncotargets Ther. 2015; 8: 3649–3664 15. [IF=5.645] Xiaojin Peng et al."Development of a novel functionality for a highly efficient imidazole-based ionic liquid non-aqueous solvent system for the complete extraction of target alkaloids from Phellodendron amurense Rupr. under ultrasound-assisted conditions. 16. [IF=1.345] Ya-Li Zhang et al."Coptisine suppresses proliferation and inhibits metastasis in human pancreatic cancer PANC-1 cells."J Asian Nat Prod Res. 2020;22(5):452-463 |
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