中文名 | 3-脱氮腺苷 |
英文名 | 3-Deazaadenosine |
别名 | 3-氮杂腺 3-氮杂腺苷 3-脱氮腺苷 3-DEAZA-腺苷 3-脱氮腺苷(3-DZA) 4-氨基-1-BETA-D-呋喃核糖基-1H-咪唑并[4,5-C]吡啶 |
英文别名 | 3dAdo Deaza-Ado NSC 167897 3-Deaza-rA 3-Deazaadenosine 3-DEAZAADENOSINE 3-Deaza-D-adenosine Adenosine, 3-deaza- 1-pentofuranosyl-1H-imidazo[4,5-c]pyridin-4-amine 4-Amino-1-(D-ribofuranosyl)-1H-imidazo(4,5)-pyridine 1H-Imidazo(4,5-c)pyridin-4-amine, 1-beta-D-ribofuranosyl- 4-AMINO-1-[BETA-D-RIBOFURANOSYL]-1H-IMIDAZO[4,5]-PYRIDINE 1H-Imidazo4,5-cpyridin-4-amine, 1-.beta.-D-ribofuranosyl- 1-(beta-D-ribofuranosyl)-1H-imidazo[4,5-c]pyridin-4-amine 1H-Imidazo(4,5-c)pyridine, 4-amino-1-beta-D-ribofuranosyl- (2R,3R,4S,5R)-2-(4-AMino-1H-iMidazo[4,5-c]pyridin-1-yl)-5-(hydroxyMethyl)tetrahydrofuran-3,4-diol |
CAS | 6736-58-9 |
化学式 | C11H14N4O4 |
分子量 | 266.25 |
InChI | InChI=1/C11H14N4O4/c12-10-7-5(1-2-13-10)15(4-14-7)11-9(18)8(17)6(3-16)19-11/h1-2,4,6,8-9,11,16-18H,3H2,(H2,12,13)/t6-,8-,9-,11-/m1/s1 |
密度 | 1.90±0.1 g/cm3 (20 ºC 760 Torr) |
熔点 | 228-229°C |
沸点 | 665.7±65.0 °C(Predicted) |
闪点 | 356.4°C |
蒸汽压 | 1.25E-18mmHg at 25°C |
溶解度 | H2O: 10mg/ml,加热至60 °C |
折射率 | 1.834 |
酸度系数 | 13.24±0.70(Predicted) |
存储条件 | Keep in dark place,Inert atmosphere,2-8°C |
外观 | 固体 |
颜色 | White to Off-White |
体外研究 | 3-Deazaadenosine is an inhibitor of S-adenosylhomocysteine hydrolase, with a K i of 3.9 µM. 3-Deazaadenosine shows anti-HIV effect, and inhibits p24 antigen in peripheral blood mononuclear (PBMCs) cells infected with HIV-1 isolates (A012 and A018) with IC 50 s of 0.15 and 0.20 µM, respectively. 3-Deazaadenosine (1-100 µM) inhibits LPS-induced expression of TNF-α mRNA, increases DNA binding activity of NF-κB, and causes proteolytic degradation of IκBα, but Not IκBβ in RAW 264.7 cells. 3-Deazaadenosine (100 µM) enhances nuclear translocation of NF-κB, but blocks LPS-induced NF-κB transcriptional activity, and such inhibition is augmented by the addition of homocysteine. 3-Deazaadenosine (50, 100 µM) dose-dependently inhibits the phosphorylation of Raf and ERK, protein-dependent kinase 1, protein kinase B (Akt), and forkhead transcription factor FoxO1a. 3-Deazaadenosine (50 µM) suppresses vascular smooth muscle cell (VSMC) proliferation via interfering with Ras signaling. |
安全术语 | 24/25 - 避免与皮肤和眼睛接触。 |
危险品运输编号 | 2811 |
WGK Germany | 3 |
海关编号 | 29419090 |
Hazard Class | 6.1(a) |
Packing Group | II |
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