68027-15-6
白头翁皂苷D(Pulsatillasaponin D)
CAS: 68027-15-6
化学式: C47H76O17
| 中文名 | 白头翁皂苷D |
| 英文名 | Pulsatillasaponin D |
| 别名 | 白头翁皂苷D 白头翁皂苷D标准品 白头翁皂苷 D, BR 常春藤皂苷元3-O-Α-L-吡喃鼠李糖-(1→2)-Β-D-吡喃葡萄糖-(1→4)-Α-L-吡喃阿拉伯糖苷 |
| 英文别名 | Pulsatillasaponin D Pulsatilla saponin D, BR Pulsatilla saponin D (SB365) Pulsatilla saponin D 68027-15-6 Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside Hederagenin 3-O-α-L-rhamnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside Olean-12-en-28-oic acid,3-[[O-6-deoxy-a-L-mannopyranosyl-(12)-O-[b-D-glucopyranosyl-(14)]-a-L-arabinopyranosyl]oxy]-23-hydroxy-, (3b,4a)- Olean-12-en-28-oic acid, 3-[[O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-α-L-arabinopyranosyl]oxy]-23-hydroxy-, (3β,4α)- |
| CAS | 68027-15-6 |
| EINECS | 211-708-6 |
| 化学式 | C47H76O17 |
| 分子量 | 913.09614 |
| 密度 | 1.40±0.1 g/cm3 (20 ºC 760 Torr) |
| 熔点 | 239-241℃ |
| 沸点 | 997.6±65.0 °C(Predicted) |
| 比旋光度 | +14.9 (Py) |
| 溶解度 | 甲醇 (微溶) 、吡啶 |
| 酸度系数 | 4.63±0.70(Predicted) |
| 存储条件 | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| 敏感性 | Easily absorbing moisture |
| 外观 | 固体 |
| 颜色 | White to Light Beige |
| 物化性质 | 白色粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于白头翁。 |
| 体外研究 | Pulsatilla saponin D (SB365) shows apoptotic effect accompanied by increased evidence of cleaved caspase-3 and poly (ADP ribose) polymerase. Pulsatilla saponin D (SB365) strongly inhibits c-Met expression in gastric cancer cells. Pulsatilla saponin D (SB365) strongly suppresses the growth and proliferation of 5 human pancreatic cancer cell lines (MIAPaCa-2, BXPC-3, PANC-1, AsPC-1 and HPAC) . Pulsatilla saponin D (SB365) shows anti-angiogenic activity by decreasing the expression of HIF-1α and VEGF. Pulsatilla saponin D (0.3 ng/mL to 10 μg/mL) exhibits anti-tumor activity in NSCLC cancer cells. Cell Cytotoxicity Assay Cell Line: A-549, SKMEL-2, MCF-7, and Lewis lung carcinoma (LLC) cells. Concentration: 0.3 ng/mL to 10 μg/mL. Incubation Time: 72 h. Result: Exhibited an ED 50 value of 6.3 μg/mL for A-549 cells. |
| 体内研究 | Pulsatilla saponin D (6.4 mg/kg) exhibits anti-tumor activity in Lewis lung carcinoma model. Animal Model: 2x2x2 mm 3 tumor fragments of a Lewis lung carcinoma (LLC) transplanted s.c. into the auxiliary region of the BDF1 mice. Dosage: 6.4 mg/kg. Administration: Intraperitoneally on the 1 st to 7 th and 9 th to 14 th day. Result: Had such a potent antitumor effect (IR, 82 %) on a solid tumor, which is higher than Adriamycin (IR, 64%). |
| 参考资料 展开查看 | 1. 严桐 易婷 郑婷婷.人体肠道菌群对人参皂苷Rg_3、白头翁皂苷D代谢转化的影响[J].中成药 2018 40(09):1902-1909. |
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现货供应
产品名: 常春藤皂苷元3-O-α-L-吡喃鼠李糖-(1→2)-β-D-吡喃葡萄糖-(1→4)-α-L-吡喃阿拉伯糖苷 去供应商网站查看 询盘CAS: 68027-15-6
产地: 中国上海
包装: 10mg
规格: 分析对照品,HPLC≥96%
价格: 2278.00
库存: 现货
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013
微信: 18017137653
产品描述: 中文名：常春藤皂苷元3-O-α-L-吡喃鼠李糖-(1→2)-β-D-吡喃葡萄糖-(1→4)-α-L-吡喃阿拉伯糖苷 英文名:Pulsatillasaponin 更多
现货供应
产品名: 常春藤皂苷元3-O-α-L-吡喃鼠李糖-(1→2)-β-D-吡喃葡萄糖-(1→4)-α-L-吡喃阿拉伯糖苷 去供应商网站查看 询盘CAS: 68027-15-6
产地: 中国上海
包装: 10mg
规格: 分析对照品,HPLC≥96%
价格: 2278.00
库存: 现货
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013
微信: 18017137653
产品描述: 中文名：常春藤皂苷元3-O-α-L-吡喃鼠李糖-(1→2)-β-D-吡喃葡萄糖-(1→4)-α-L-吡喃阿拉伯糖苷 英文名:Pulsatillasaponin 更多
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