758679-97-9_化工百科

中文名	CID-2858522
英文名	CID-2858522
英文别名	100844 CID2858522 CID-2858522 CID 2858522 1-(3,5-Di-tert-butyl-4-hydroxyphenyl)-2-(2-(3-hydroxypropylamino)-5,6-dimethyl-1H-benzo[d]imid 1-(3,5-di-tert-butyl-4-hydroxyphenyl)-2-(2-(3-hydroxypropylaMino)-5,6-diMethyl-1H-benzo[d]iMidazol-1-yl)ethanone 1-[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-[2-[(3-hydroxypropyl)amino]-5,6-dimethyl-1H-benzimidazol-1-yl]-ethanone Ethanone, 1-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-[2-[(3-hydroxypropyl)amino]-5,6-dimethyl-1H-benzimidazol-1-yl]-
CAS	758679-97-9
EINECS	804-713-5
化学式	C28H39N3O3
分子量	465.63
密度	1.12±0.1 g/cm3(Predicted)
沸点	618.9±65.0 °C(Predicted)
溶解度	DMSO: 溶解2mg/mL，澄清 (温热)
酸度系数	8.46±0.40(Predicted)
存储条件	2-8°C
外观	粉末
颜色	white to beige
MDL号	MFCD20755108
体外研究	CID-2858522 (Compound 1) inhibits antigen receptor-mediated NF-κB with an IC 50 of 70 nM. CID-2858522 also inhibits testosterone hydroxylase in the presence of human liver microsomes (HLM) and an NADPH generating system with an IC 50 of 85 μM. In the HEK293 cell line used for primary screening, CID-2858522 suppresses NF-κB reporter gene activity in a concentration-dependent manner, with IC 50 ~70 nM and with maximum inhibition achieved at 0.25-0.5 μM. In contrast, CID-2858522 does not inhibit TNF-induced NF-κB-reporter gene activity at concentrations as high as 4 μM, thus demonstrating selectivity for the NF-κB pathway activated by PMA/Ionomycin. Cell viability assays indicate that CID-2858522 is not toxic to HEK293 cells at concentrations ≤8 μM. CID-2858522 also potently inhibits PMA/Ionomycin-induced NF-κB reporter gene activity in transient transfection assays.
体内研究	In vivo dose-exposure profiling of CID-2858522 (Compound 1a) is conducted using a small cohort of three male mice. CID-2858522 exhibits nonlinear pharmacokinetics, showing higher serum levels at the 0.5 h measurement time for the 30 mg/kg dose compared to 50 mg/kg but displaying typical dose-dependent behavior when measured at t=3 h. The increasing accumulation seen at a dose of 50 mg/kg may be due to a depot effect created by CYP3A4 inhibition. The cohort exhibits clear signs of morbidity at t=3 h at the 50 mg/kg dose.
危险品标志	T - 有毒物品
风险术语	25 - 吞食有毒。
安全术语	45 - 若发生事故或感不适，立即就医(可能的话，出示其标签)。
危险品运输编号	UN 2811 6.1 / PGIII
WGK Germany	3

758679-97-9 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	2.148 ml	10.738 ml	21.476 ml
5 mM	0.43 ml	2.148 ml	4.295 ml
10 mM	0.215 ml	1.074 ml	2.148 ml
5 mM	0.043 ml	0.215 ml	0.43 ml

最后更新：2024-01-02 23:10:35

758679-97-9 - 简介

CID-2858522是一种化学化合物，其具体的化学性质和结构式没有给出。
通常，化合物的用途可以根据其化学性质和结构进行推测。
相应的安全信息应该基于化合物的化学性质、毒性和危险性来评估。请确保在使用化合物之前查阅可靠的化学文献或与化学专家咨询，以获取相关的详细信息。

最后更新：2024-04-09 20:48:19

上海吉至生化科技有限公司

现货供应

产品名: CID-2858522 去供应商网站查看询盘
CAS: 758679-97-9
产地: 中国上海
包装: 10mg
规格: 96%
价格: 998.00
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产品描述: 中文名：CID-2858522 英文名:CID-2858522 CAS:758679-97-9 规格:96% 产地:中国上海

上海麦克林生化科技股份有限公司

现货供应

产品名: CID-2858522 去供应商网站查看询盘
CAS: 758679-97-9
产地: 上海
规格: C877508
价格: 10mg-2420,5mg-1540
库存: 15天内发货
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上海源叶生物科技有限公司

产品名: CID-2858522 去供应商网站查看询盘
CAS: 758679-97-9
产地: 上海
规格: 95%
价格: 5mg 560,10mg 1000
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