中文名 | 8-O-乙酰山栀苷甲酯 |
英文名 | 8-O-Acetyl shanzhiside methyl ester |
别名 | 8-O-乙酰山栀苷甲酯 8-O-乙酰山栀苷甲酯(对照品) 8-O-乙酰山栀苷甲酯(标准品) 8-O-乙酰山栀苷甲酯, 来源于独一味 8-O-ACETYL SHANZHISIDE METHYL ESTER 8-O-乙酰山栀苷甲酯 |
英文别名 | Barlerin UMbroside 8-Acetylshanzhiside Methyl ester 8-O-Acetyl shanzhiside methyl ester O-Acetyl Shanzhiside Methyl Ester, 8- 1α-(β-D-Glucopyranosyloxy)-7α-acetoxy-5α-hydroxy-7-methyl-1,4aα,5,6,7,7aα-hexahydrocyclopenta[c]pyran-4-carboxylic acid methyl ester 7α-Acetoxy-1α-(β-D-glucopyranosyloxy)-1,4aα,5,6,7,7aα-hexahydro-5α-hydroxy-7-methylcyclopenta[c]pyran-4-carboxylic acid methyl ester (1S)-1α-(β-D-Glucopyranosyloxy)-5α-hydroxy-7α-acetoxy-7-methyl-1,4aα,5,6,7,7aα-hexahydrocyclopenta[c]pyran-4-carboxylic acid methyl ester |
CAS | 57420-46-9 |
化学式 | C19H28O12 |
分子量 | 448.42 |
密度 | 1.52 |
熔点 | 180°C |
沸点 | 634.2±55.0 °C(Predicted) |
比旋光度 | -8.5 (c, 0.8 in MeOH). -74.8 (c, 0.1 in MeOH) |
溶解度 | 易溶于水、甲醇和乙醇,难溶于丁醇和乙酸乙酯,不溶于氯仿、苯和石油醚。 |
酸度系数 | 12.80±0.70(Predicted) |
存储条件 | 2-8℃ |
外观 | 白色结晶 |
物化性质 | 类白色结晶粉末,易溶于甲醇乙醇,来源于独一味。 |
MDL号 | MFCD15071141 |
体外研究 | Treatment of SH-SY5Y cells with Barlerin (8-O-Acetyl shanzhiside methyl ester) blocks TNF-α-induced nuclear transcription factor κB (NF-κB) activation and decreases high-mobility group box-1 (HMGB-1) expression. . Treatment of H9c2 cells with Barlerin (8-O-Acetyl shanzhiside methyl ester) 9 μM blocks TNF-α-induced NF-κB phosphorylation by blocking High-mobility group box1 (HMGB1) expression. |
体内研究 | Barlerin (8-O-Acetyl shanzhiside methyl ester) 40 mg/kg demonstrates significant neuroprotective effect even after delayed administration at 4 hr after I/R. Barlerin 40 mg/kg attenuates the histopathological damage, decreases brain swelling, inhibits NF-κB activation and reduces HMGB-1 expression in ischaemic brain tissue. Barlerin (8-O-Acetyl shanzhiside methyl ester) significantly promotes angiogenesis in the ischaemic brain and improves functional outcome after stroke. Barlerin also significantly increases vascularization compared with vehicle treatment. It increases the expression of VEGF, Ang1, phosphorylation of Tie2 and Akt VEGF. Barlerin (8-O-Acetyl shanzhiside methyl ester) significantly shortens capillary blood clotting time and reduces blood loss volume, but does not influence mice activated partial thromboplastin time, prothrombin time or thrombin time. It significantly prolongs euglobulin clot lysis time in hyperfibrinolysis mice. |
安全术语 | 24/25 - 避免与皮肤和眼睛接触。 |
海关编号 | 29389090 |
参考资料 展开查看 | 1. 覃柳莹,蔡梦如,姚宇,白杰,吴慧敏,张志勤,张硕峰,倪健,格桑顿珠,尹兴斌.藏药四臣止咳颗粒的指纹图谱研究[J].中南药学,2021,19(03):507-512. 2. [IF=3.512] Chenning Zhang et al."LC–MS-Based Qualitative Analysis and Pharmacokinetic Integration Network Pharmacology Strategy Reveals the Mechanism of Phlomis brevidentata H.W.Li Treatment of Pneumonia."Acs Omega. 2021;6(6):4495–4505 |
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