84687-45-6
黄芪皂苷VI(Astragaloside VI )
CAS: 84687-45-6
化学式: C47H78O19
| 中文名 | 黄芪皂苷VI |
| 英文名 | Astragaloside VI |
| 别名 | 黄芪甲苷VI 黄芪皂苷VI 化合物 T13559 黄芪皂苷VI 黄芪皂苷X2 |
| 英文别名 | Astragaloside VI Astragaloside VI β-D-Glucopyranoside, (3β,6α,16β,20R,24S)-20,24-epoxy-3-[(2-O-β-D-glucopyranosyl-β-D-xylopyranosyl)oxy]-16,25-dihydroxy-9,19-cyclolanostan-6-yl (3beta,6alpha,16beta,20R,24S)-20,24-Epoxy-3-[(2-O-beta-D-glucopyranosyl-beta-D-xylopyranosyl)oxy]-16,25-dihydroxy-9,19-cyclolanostan-6-yl beta-D-glucopyranoside |
| CAS | 84687-45-6 |
| 化学式 | C47H78O19 |
| 分子量 | 947.11 |
| 溶解度 | 10毫米DMSO |
| 存储条件 | 2-8℃ |
| MDL号 | MFCD17214426 |
| 体外研究 | Pretreatment with Astragaloside VI (AS-VI) at 1 μM increases EGFR activation in HaCaT cells. Astragaloside VI, a major intestinal metabolite of astragalosides, exerts the strongest EGFR activation. In HaCaT cells, the positive control, EGF expectedly results in 1.5±0.03-fold increase in cell proliferation, compared to the control. Astragaloside VI at the indicated concentrations also significantly promots cell proliferation in both HaCaT and HDF cells. Astragaloside VI promotes neural stem cell proliferation and enhances neurological function recovery in transient cerebral ischemic injury via activating EGFR/MAPK signaling cascades. |
| 体内研究 | Astragaloside VI improves wound healing, compared to the control. In the simple noninfected wound model, wound healing in mice is accelerated by Astragaloside VI, where in the time required for wound closure is shortened by approximately 2-4 days, compared to that in the control group. Topical treatment with Astragaloside VI reduces the volume of pus produced, compared to the control group. Astragaloside VI treated wounds show an accelerated rate of healing, compared to the control and vaseline groups. By day 22, the Astragaloside VI -treated wounds fully close, whereas the blank and vaseline-treated wounds do not fully close until day 26. Angiogenesis is a crucial step in the formation of granulation tissue and wound healing. Astragaloside VI increases blood vessel formation in both the non-infected and infected wound models. Astragaloside VI could effectively activate EGFR/MAPK signaling cascades, promote NSCs proliferation and neurogenesis in transient cerebral ischemic brains, and improve the repair of neurological functions in post-ischemic stroke rats. |
| 参考资料 展开查看 | 1. 李洋洋,张苡铭,魏孔熙,周婷,何进鹏,丁楠,周谷城,史桐凡,柯宜诚,牛帆,刘永琦,张利英.黄芪不同有效成分对电离辐射致BMSCs DNA损伤防护作用的比较研究[J].中国药房,2020,31(24):2987-2992. 2. Yuping Zhang, Shuyun Shi, Junfang Guo, Qingping You, Deshan Feng, On-line surface plasmon resonance-high performance liquid chromatography–tandem mass spectrometry for analysis of human serum albumin binders from Radix Astragali, Journal of Chromatography |
84687-45-6 - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.056 ml | 5.279 ml | 10.558 ml |
| 5 mM | 0.211 ml | 1.056 ml | 2.112 ml |
| 10 mM | 0.106 ml | 0.528 ml | 1.056 ml |
| 5 mM | 0.021 ml | 0.106 ml | 0.211 ml |
最后更新：2024-01-02 23:10:35
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产品名: Astragaloside VI 去供应商网站查看 询盘CAS: 84687-45-6
产地: 中国上海
包装: 5mg
规格: 98%
价格: 5388.00
库存: 现货
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013
微信: 18017137653
产品描述: 中文名：Astragaloside VI 英文名:Astragaloside VI CAS:84687-45-6 规格:98% 产地:中国上海
现货供应
产品名: Astragaloside VI 去供应商网站查看 询盘CAS: 84687-45-6
产地: 中国上海
包装: 5mg
规格: 98%
价格: 5388.00
库存: 现货
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013
微信: 18017137653
产品描述: 中文名：Astragaloside VI 英文名:Astragaloside VI CAS:84687-45-6 规格:98% 产地:中国上海
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