中文名 | 1-(4,4-二苯基-3-丁烯基)-3-哌啶盐酸盐 |
英文名 | N-(4,4-Diphenyl-3-butenyl)nipecotic acid hydrochloride |
别名 | 4-二苯基-3-丁烯基)-3-哌啶盐酸盐 1-(4,4-二苯基-3-丁烯基)-3-哌啶盐酸盐 1-(4,4-二苯基-3-丁烯-1-基)-3-哌啶甲酸盐酸盐 1 - (4,4 - 二苯基-3 - 丁烯基)- 3 -哌啶盐酸盐 |
英文别名 | skf-89976a SKF89976AHCl SKF 89976A HYDROCHLORIDE l-SKF89976A hydrochloride d,l-SKF89976A hydrochloride N-(4,4-Diphenyl-3-butenyl)nipecotic acid hydrochloride 4-(3-Carboxypiperidine)-1,1-diphenyl-1-butene hydrochloride 1-(4,4-DIPHENYL-3-BUTENYL)-3-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE 1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid hydrochloride 1-(4,4-Diphenylbut-3-en-1-yl)piperidine-3-carboxylic acid hydrochloride 1-(4,4-Diphenyl-3-buten-1-yl)-3-piperidinecarboxylic acid hydrochloride 1-(4,4-diphenylbut-3-en-1-yl)piperidine-3-carboxylic acid hydrochloride |
CAS | 85375-15-1 |
化学式 | C22H26ClNO2 |
分子量 | 371.9 |
InChI | InChI=1/C22H25NO2.ClH/c24-22(25)20-13-7-15-23(17-20)16-8-14-21(18-9-3-1-4-10-18)19-11-5-2-6-12-19;/h1-6,9-12,14,20H,7-8,13,15-17H2,(H,24,25);1H |
沸点 | 531.4°C at 760 mmHg |
闪点 | 275.2°C |
蒸汽压 | 4.04E-12mmHg at 25°C |
溶解度 | DMSO: 20mg/ml,可溶 |
存储条件 | Inert atmosphere,2-8°C |
外观 | 固体 |
颜色 | white |
体外研究 | SKF89976A has a weak antiallodynic action. SKF89976A weakly inhibits serotonin transporter (SERT), noradrenaline transporter (NET), and dopamine transporter (DAT) in chinese hamster ovary (CHO) cells stably expressing each transporter using a substrate uptake assay, with IC 50 values of 3514 , 202.13, and 728.8, respectively. SKF89976A is a GABA-transport blocker. GABA (1 mM) elicited an inward current that is completely suppressed by the GABA transport inhibitors tiagabine (10 μM) and SKF89976A (100 μM), but is unaffected by 100 μM picrotoxin. 100 μM SKF 89976-A is known to block the transport of GABA into cells, completely eliminated the GABA-elicited current in a reversible fashion. SKF89976A is a nontransportable blockers of GAT-1. SKF89976-A also suppresses baseline inward currents that likely result from tonic GAT activation by background GABA. SKF89976A (100 μM) reversibly reduces GAT currents in every studied cell by 67.9±4.4% (n=19). Intracellular perfusion of 20 μM SKF89976-A progressively reduced and blocked GABA-induced GAT currents without blocking GABAAR-mediated currents (n=4). |
体内研究 | SKF89976A produces a weak antiallodynic response when administered i.v. (0.3 mg/kg). The i.t. injection of SKF89976A dose-dependently ameliorates the reduction in the withdrawal threshold in PSL model mice. |
WGK Germany | 3 |
RTECS | TM6241000 |
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